CLASS III RECEPTOR TYROSINE KINASES THAT BIND HELICAL-BUNDLE LIGANDS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。跨膜受体缺陷/故障经常导致或促成癌症。调节这些受体有望开发癌症治疗方法，但需要了解激素/生长因子如何通过这些受体发挥作用。KIT是干细胞因子(SCF)的受体，对人类至关重要。KIT功能障碍与胃肠道间质瘤、生殖细胞瘤和急性髓系白血病有关。阐明KIT和SCF之间的相互作用机制可能为开发抗KIT相关癌症的策略提供途径。我们建议从结构和功能两个方面研究KIT/SCF的相互作用。利用X射线衍射，我们正在获得KIT/SCF复合体的高分辨率原子图像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Transmembrane receptor defects/malfunctions frequently cause or contribute to cancer. Modulating these receptors holds promises for developing cancer therapies, but understanding how hormones/growth factors act through these receptors is required. KIT, the receptor for Stem Cell Factor (SCF), is essential for humans. Kit malfunctioning is associated with gastrointestinal stromal tumors, germ cell tumors and acute myeloid leukemia. Elucidating the interaction mechanism between KIT and SCF may provide avenues for developing strategies against KIT-related cancers. We propose to study the KIT/SCF interactions both structurally and functionally. Using X-ray diffraction, we are in progress of getting high-resolution atomic images of the KIT/SCF complex.