Defining the role of type III collagen and the collagen-binding receptor DDR1 in metastatic dormancy
定义 III 型胶原和胶原结合受体 DDR1 在转移休眠中的作用
基本信息
- 批准号:10263927
- 负责人:
- 金额:$ 38.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-15 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AdultAftercareBindingBiologyBlood VesselsBone MarrowBrainCancer PatientCause of DeathCell CommunicationCell CycleCell ProliferationCell physiologyCellsCessation of lifeCollaborationsCollagenCollagen FibrilCollagen ReceptorsCollagen Type IVDDR1 geneDataDepositionDiseaseDisseminated Malignant NeoplasmDown-RegulationExtracellular MatrixFibrillar CollagenFibronectinsGene Expression ProfilingGenerationsGenetic TranscriptionGoalsGrowthImaging DeviceImmuneInterruptionInterventionLiverLungMalignant NeoplasmsMeasuresMediatingMessenger RNAMethodologyMethodsModelingMolecularNeoplasm MetastasisNon-Fibrillar CollagensOrganOutcomePathway interactionsPatientsPhenotypePhosphorylationPrimary NeoplasmProcessProteinsProteomeProteomicsReporterResearch DesignRoleSTAT1 geneSeedsSignal TransductionSiteStromal CellsTenascinTestingTimeTranscriptTumor-DerivedWorkbasecancer cellhigh resolution imagingimaging approachimprovedin vivoinnovationmigrationmultiphoton imagingneoplastic cellnovelp38 Mitogen Activated Protein Kinasepreventprotein expressionreceptor bindingsecond harmonicstem cellstranscriptomicstumortumor growth
项目摘要
Project Summary/Abstract
Background: Metastasis is the primary cause of death of cancer patients. Disseminated tumor cells (DTCs)
leave the primary tumor and seed target organs originating metastasis, years or decades after treatment. This
delay in growth is mediated by a process called tumor dormancy. The extracellular matrix (ECM)-tumor cell
interactions have been shown to regulate the hallmark of cancer; from primary tumor growth to migration,
invasion and metastasis. However, how ECM sensing and remodeling can induce and sustain dormancy of
DTCs is unclear. Moreover, whether DTCs assemble dormancy-supportive ECM niches to sustain their
phenotype is also an unanswered question. We will explore the hypothesis that ECM remodeling by dormant
cells contribute to tumor dormancy by constructing a dormant ECM niche rich in collagen III (COL III).
Hypothesis: Our overall hypothesis states that dormant cancer cells can construct their own “dormancy-
supportive niche” by remodeling and depositing a COL III rich ECM that sustain their phenotype.
Objective: The overall goal of this project is two-fold: 1) to understand the role of the COL III ECM on the
formation of dormancy-supportive niches and 2) to determine how the interaction with the collagen III ECM
through DDR1 regulates the dormancy-to-reactivation transition.
Specific Aims: #1: To determine how fibrillar collagen III networks contribute to establish a dormancy-supportive
niche. #2: To identify the molecular mechanisms through which collagen receptor DDR1 modulates assembly of
a pro-quiescence ECM.
Study design/Methods: 1) The approaches available to study the biology of dormant cells in real-time in vivo
are limited. We propose to use high-resolution imaging tools combined with dormancy models to study tumor
cell-ECM interactions during dormancy. We have been developing an imaging approach that includes: i)
Multiphoton imaging and second harmonic generation (SHG) and ii) activity reporters for dormancy-related
specific pathways to measure changes in p38/ERK signaling and cell cycle status during dormancy. 2) To
analyze the ECM composition and remodeling we use quantitative proteomics in collaboration with Dr. Naba.
Relevance: This project is innovative both at the conceptual and at the methodological level. We propose to
study the following aspects of metastasis: 1) how DTCs create a dormant ECM niche enriched in COL III to
sustain dormancy; 2) the role of COL III/DDR1 interaction in regulating dormancy; 3) how IFNg/STAT1 signaling
regulates tumor dormancy through ECM remodeling; 4) how disruption of a pro-quiescence ECM proteome and
increase in LTBP1 mediate dormancy-to-reactivation transition. We expect our studies to have a significant
impact on biomedicine because they will uncover the mechanisms regulating dormant cell-ECM interactions,
which will be an efficient way of identifying targets to prevent metastasis.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jose Javier Bravo-Cordero其他文献
Jose Javier Bravo-Cordero的其他文献
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{{ truncateString('Jose Javier Bravo-Cordero', 18)}}的其他基金
IMAT-ITCR Collaboration: Artificial intelligence enhanced breast cancer dormancy cell classification-based organelle-morphology and topology
IMAT-ITCR 合作:人工智能增强乳腺癌休眠细胞分类的细胞器形态和拓扑
- 批准号:
10884760 - 财政年份:2023
- 资助金额:
$ 38.77万 - 项目类别:
Intersectional genetics-based biosensors for dormant cancer cells
基于交叉遗传学的休眠癌细胞生物传感器
- 批准号:
10612300 - 财政年份:2023
- 资助金额:
$ 38.77万 - 项目类别:
Recording the natural history of cancer progression using a Crainbow model of HER2+ cancer
使用 HER2 癌症的 Crainbow 模型记录癌症进展的自然史
- 批准号:
10630320 - 财政年份:2022
- 资助金额:
$ 38.77万 - 项目类别:
Recording the natural history of cancer progression using a Crainbow model of HER2+ cancer
使用 HER2 癌症的 Crainbow 模型记录癌症进展的自然史
- 批准号:
10437462 - 财政年份:2022
- 资助金额:
$ 38.77万 - 项目类别:
Defining the role of type III collagen and the collagen-binding receptor DDR1 in metastatic dormancy
定义 III 型胶原和胶原结合受体 DDR1 在转移休眠中的作用
- 批准号:
10439836 - 财政年份:2020
- 资助金额:
$ 38.77万 - 项目类别:
Defining the role of type III collagen and the collagen-binding receptor DDR1 in metastatic dormancy
定义 III 型胶原和胶原结合受体 DDR1 在转移休眠中的作用
- 批准号:
10653992 - 财政年份:2020
- 资助金额:
$ 38.77万 - 项目类别:
Protrusion plasticity during in vivo tumor cell migration
体内肿瘤细胞迁移过程中的突出可塑性
- 批准号:
9321473 - 财政年份:2016
- 资助金额:
$ 38.77万 - 项目类别:
Protrusion plasticity during in vivo tumor cell migration
体内肿瘤细胞迁移过程中的突出可塑性
- 批准号:
9534544 - 财政年份:2016
- 资助金额:
$ 38.77万 - 项目类别:
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