Pre-doctoral Research Training in Human Genetic Epidemiology

描述（由申请人提供）：超出所提供的空间。这个重新修订的博士前培训资助申请，提交了对NIH PA-02-109的回应，要求通过整合生物统计学和计算科学，支持在“跨文化”跨学科环境中培养未来的遗传流行病学家（遗传流行病学，生物统计学，统计遗传学和生物信息学）与生物科学（人类遗传学，分子生物学和基因组学）使用非常成功和有效的动手方法。我们相对较新的“定量人类和统计遗传学”博士前课程融合了传统和非传统方法。该计划的主要目标是：（1）在分子方法和分子数据分析技术方面培训遗传流行病学家和统计遗传学家，以及（2）在统计遗传学方法和方法方面培训人类遗传学家，以便他们能够胜任分析他们产生的数据。我们相信，这个博士前课程将有效地减少文化冲击，往往抑制遗传流行病学家充分参与跨学科研究。这项培训补助金的资金将支持这一新开发的计划，该计划将针对本科专业为统计科学或生物科学的研究生，并在另一个方面具有一定程度的熟练程度。我们要求在第一年提供4个名额，此后提供6个名额。我们的建议通过混合和整合精心选择的教学培训，更加强调直接动手学习的形式，在华盛顿大学取得了巨大的成功。该培训计划的一大优势是，整个DBBS的庞大的既定资源和丰富的跨学科培训环境，以及另一个硕士学位培训计划（GEMS），也可用于该计划的所有博士前学生。这是我们的希望，通过让我们的学生接触到成熟的DBBS课程和资源的全面广度和深度，我们确保我们的学生将以非常自然的方式与生物医学科学完全融合，从而也确保有效的“跨文化”培训。我们相信，我们的培训计划是非常在PA的精神，渴望产生未来的遗传流行病学家在目前的市场需求很大，追求合作生物医学研究。

Description (provided by applicant): EXCEED THE SPACE PROVIDED. This re-revised pre-doctoral training grant application, submitted in response to NIH PA-02-109, requests support to train future Genetic Epidemiologists in a "cross-culture" interdisciplinary environment by integrating biostatistical and computational sciences (genetic epidemiology, biostatistics, statistical genetics, and bioinformatics) with biological sciences (human genetics, molecular biology, and genomics) using a highly successful and effective hands-on approach. Our relatively new pre-doctoral program in "Quantitative Human and Statistical Genetics" blends traditional and non-traditional approaches. The primary objectives of this program are: (1) To train Genetic Epidemiologists and Statistical Geneticists in molecular methods and molecular data analysis techniques, and (2) To train Human Geneticists in statistical genetics approaches and methods so that they can analyze competently the data they generate. We believe that this pre-doctoral program will effectively minimize the culture shock that often inhibits genetic epidemiologists from participating fully in interdisciplinary research. Funding of this training grant will support this newly developed program which will target graduate students whose undergraduate major was in either statistical sciences or biological sciences with some degree of proficiency in the other. We are requesting funds for 4 slots in the first year and 6 thereafter. Our proposal rises to the challenge by blending and integrating carefully chosen didactic training with greater emphasis on a direct hands-on learning format found to be immensely successful at Washington University. One of the great strengths of this training program is that the vast established resources and rich interdisciplinary training environment of the entire DBBS, as well as that of another masters degree training program (GEMS), are also available to all pre-doctoral students in this program. It is our hope that, by exposing our students to the full breadth and depth of the mature DBBS programs and resources, we are ensuring that our students will be fully integrated with the biomedical sciences in a very natural manner thus also ensuring effective "cross-culture" training. We believe that our training program is very much in the spirit of the PA, aspiring to produce future genetic epidemiologists in much demand in the current market place for pursuing collaborative biomedical research.