Nutrition and Cardiovascular Disease Predoctoral Research Training Program

营养与心血管疾病博士前研究培训项目

• 批准号: 7439640
• 负责人: ALICE H LICHTENSTEIN
• 金额: $ 17.12万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7439640
• 关键词: Cardiovascular Diseases; Research Training; Training Programs; nutrition; pre-doctoral

Description (provided by applicant): The objective of this proposal is to obtain funds for the training of highly qualified PhD scientists committed to a research career in the area of nutrition and cardiovascular disease (CVD) at a basic, clinical, epidemiological, and/or translational level. Despite advances in the past two decades, CVD is still the leading cause of disability and death in the U.S. It costs the nation approximately $432 billion annually, a figure in excess of 20% of the total national healthcare expenditures. Given the continued demographic shift in the U.S. towards the older age groups, this burden is predicted to increase. Lifetime risk for CVD and median survival rate is strongly associated with risk factor burden at age 50 years. Understanding the underlying mechanism(s) of this association and refining optimal approaches to minimize CVD risk factor burden is critical to advancing approaches to decreasing CVD incidence and improving prognosis. The rational for this proposal is based on the firm belief that nutrition is the most significant modifiable lifestyle behavior that can alter CVD risk. This proposal seeks funds to train the next generation of researchers to address CVD genesis, prevention, and treatment at a molecular, cellular, whole organism, and population level. Continued support is requested for the four predoctoral training slots for each of five years. All trainees are first admitted to the PhD program at the Friedman School of Nutrition Science and Policy. After one or two years of coursework (depending on prior training) students are eligible to be admitted to the Training Program. Acceptance is predicated upon outstanding academic and research achievement, and establishing a doctoral research project in the area of nutrition and CVD. Training Program faculty have a proven record in their ability to provide exemplary training to predoctoral students. Critical components of the Training Program include didactic training in nutrition, basic sciences and epidemiology; independent mentored research in the area of biochemical and molecular nutrition or nutritional epidemiology (doctoral thesis); preparation and submission and/or publication of research in peer-reviewed journals; oral and poster presentation of research in public forums; NIH-style research proposal preparation and defense; and training in scientific ethics and research responsibility. Training Program administration and trainee supervision will be the responsibility of the program director and Steering Committee, which will meet semi-annually to review and discuss trainee selection and progress, adequacy of mentoring, and transition of trainees to independent researchers. We believe the training environment at the Friedman School and Tufts Univeristy provides an outstanding opportunity for future researchers in the area of nutrition and CVD and continued support in both the scientific future of the trainees and the public health of the nation is a good investment.

描述（由申请人提供）：本提案的目的是获得资金，用于培训高素质的博士科学家，致力于在基础，临床，流行病学和/或翻译水平的营养和心血管疾病（CVD）领域的研究事业。尽管在过去二十年中取得了进展，但CVD仍然是美国残疾和死亡的主要原因，每年花费约4320亿美元，超过全国医疗保健总支出的20%。鉴于美国人口结构持续向老年群体转移，预计这一负担将增加。CVD的终生风险和中位生存率与50岁时的风险因素负担密切相关。了解这种关联的潜在机制并改进最佳方法以最大限度地减少CVD风险因素负担对于推进降低CVD发病率和改善预后的方法至关重要。这一建议的理由是基于坚定的信念，即营养是可以改变CVD风险的最重要的可改变的生活方式行为。该提案寻求资金来培训下一代研究人员，以在分子，细胞，整个生物体和人群水平上解决CVD的发生，预防和治疗。要求继续为五年中每年的四个博士前培训名额提供支持。所有学员首先被弗里德曼营养科学与政策学院的博士课程录取。经过一两年的课程学习（取决于之前的培训）后，学生有资格被录取参加培训计划。接受是基于杰出的学术和研究成就，并建立在营养和心血管疾病领域的博士研究项目。培训计划的教师有一个证明他们的能力，提供示范性的培训，博士生的记录。培训计划的关键组成部分包括营养、基础科学和流行病学方面的教学培训;生物化学和分子营养或营养流行病学领域的独立指导研究（博士论文）;准备和提交和/或在同行评议的期刊上发表研究;在公共论坛上口头和海报展示研究; NIH式的研究提案准备和辩护;以及科学道德和研究责任方面的培训。培训计划管理和受训者监督将由计划主任和指导委员会负责，该委员会将每半年召开一次会议，审查和讨论受训者的选择和进展、指导的充分性以及受训者向独立研究人员的过渡。我们相信，弗里德曼学院和塔夫茨大学的培训环境为营养和心血管疾病领域的未来研究人员提供了一个绝佳的机会，并继续支持受训人员的科学未来和国家的公共卫生是一项很好的投资。