Nutrition and Cardiovascular Disease Predoctoral Research Training Program

营养与心血管疾病博士前研究培训计划

• 批准号: 8294693
• 负责人: ALICE H LICHTENSTEIN
• 金额: $ 8.18万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2013-07-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8294693
• 关键词: Cardiovascular Diseases; Research Training; Training Programs; nutrition; pre-doctoral

Description (provided by applicant): The objective of this proposal is to obtain funds for the training of highly qualified PhD scientists committed to a research career in the area of nutrition and cardiovascular disease (CVD) at a basic, clinical, epidemiological, and/or translational level. Despite advances in the past two decades, CVD is still the leading cause of disability and death in the U.S. It costs the nation approximately $432 billion annually, a figure in excess of 20% of the total national healthcare expenditures. Given the continued demographic shift in the U.S. towards the older age groups, this burden is predicted to increase. Lifetime risk for CVD and median survival rate is strongly associated with risk factor burden at age 50 years. Understanding the underlying mechanism(s) of this association and refining optimal approaches to minimize CVD risk factor burden is critical to advancing approaches to decreasing CVD incidence and improving prognosis. The rational for this proposal is based on the firm belief that nutrition is the most significant modifiable lifestyle behavior that can alter CVD risk. This proposal seeks funds to train the next generation of researchers to address CVD genesis, prevention, and treatment at a molecular, cellular, whole organism, and population level. Continued support is requested for the four predoctoral training slots for each of five years. All trainees are first admitted to the PhD program at the Friedman School of Nutrition Science and Policy. After one or two years of coursework (depending on prior training) students are eligible to be admitted to the Training Program. Acceptance is predicated upon outstanding academic and research achievement, and establishing a doctoral research project in the area of nutrition and CVD. Training Program faculty have a proven record in their ability to provide exemplary training to predoctoral students. Critical components of the Training Program include didactic training in nutrition, basic sciences and epidemiology; independent mentored research in the area of biochemical and molecular nutrition or nutritional epidemiology (doctoral thesis); preparation and submission and/or publication of research in peer-reviewed journals; oral and poster presentation of research in public forums; NIH-style research proposal preparation and defense; and training in scientific ethics and research responsibility. Training Program administration and trainee supervision will be the responsibility of the program director and Steering Committee, which will meet semi-annually to review and discuss trainee selection and progress, adequacy of mentoring, and transition of trainees to independent researchers. We believe the training environment at the Friedman School and Tufts Univeristy provides an outstanding opportunity for future researchers in the area of nutrition and CVD and continued support in both the scientific future of the trainees and the public health of the nation is a good investment.

描述（由申请人提供）：该提案的目的是为在营养和心血管疾病（CVD）领域的研究生涯中培训高素质的博士学位科学家（CVD）的资金，以基本的，临床的，流行病学和/或翻译水平进行培训。尽管在过去的二十年中取得了进步，但CVD仍然是美国残疾和死亡的主要原因，该国每年花费约4320亿美元，这一数字超过了国家医疗保健总支出的20％。鉴于美国的人口持续转变向年龄段的年龄段，预计这种负担将增加。 CVD和中位生存率的终生风险与50岁时的风险因素负担密切相关。了解这种关联的潜在机制以及最大程度地减少CVD风险因素负担的最佳方法，对于降低CVD发病率和改善预后的方法至关重要。该提案的理性是基于坚定的信念，即营养是可以改变CVD风险的最重要的改变生活方式行为。该提案寻求资金来培训下一代研究人员，以分子，细胞，整个生物体和人群水平来解决CVD创世纪，预防和治疗。持续支持五年中的四个五个训练插槽。所有学员首先被弗里德曼营养科学与政策学院的博士学位课程录取。经过一两年的课程（根据先前的培训），学生有资格参加培训计划。接受基于杰出的学术和研究成就，并在营养和CVD领域建立博士研究项目。培训课程教师在为前学生提供示例性培训的能力方面具有可靠的记录。培训计划的关键组成部分包括营养，基础科学和流行病学的教学培训；独立的指导研究在生化和分子营养或营养流行病学领域（博士学位论文）；在同行评审期刊上准备，提交和/或出版研究；公共论坛中研究的口头和海报介绍； NIH风格的研究建议准备和防御；以及科学伦理和研究责任的培训。培训计划管理和学员的监督将是计划主任和指导委员会的责任，该委员会将在半年度举行会议，以审查和讨论受训者的选择和进步，指导的是否足够以及将受训者过渡到独立研究人员。我们认为，弗里德曼学校和塔夫茨大学的培训环境为营养和CVD领域的未来研究人员提供了一个绝佳的机会，并在受训者的科学未来和国家公共卫生的科学未来和公共卫生中持续支持是一项不错的投资。