High-Throughput Synthesis and Screening of Potential Xanthine Oxidase Inhibitors

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Potent inhibitors of the enzyme xanthine oxidase are needed urgently in order to combat the recent increase in gout. The aim of this secondment is to use high-throughput methodology to rapidly design, synthesise and evaluate a range of potential inhibitors. These inhibitor molecules are of mutual interest for the applicants since they fit well into the selection of drug candidates of the industrial company and they help the development of luminescent probes for the enzyme on the academic side. By choosing an enzyme that contains a metal in the active site as target, we are taking advantage of the complementary expertise provided by the applicants: bioinorganic chemistry (AKDK) and structure-based drug discovery (Sareum).