Long-term White Matter Changes Resulting from Delirium after Surgery

手术后谵妄导致的长期白质变化

• 批准号: 7387042
• 负责人: JAMES L RUDOLPH
• 金额: $ 5.67万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7387042
• 关键词: Abdomen; Acute; Affect; Age; Anisotropy; Area; Arts; Attention; Blood Vessels; Brain; Brain imaging; Cognition; Cognitive; Complication; Delirium; Diffusion Magnetic Resonance Imaging; Disease; Exhibits; Future; Home environment; Hospitalization; Image; Impairment; Life; Magnetic Resonance; Measures; Modality; Neurologic; Operative Surgical Procedures; Outcome; Patients; Performance; Postoperative Period; Psyche structure; Risk; Testing; Week; frontal lobe; in vivo; interest; neuropsychological; prevent; white matter; white matter change

DESCRIPTION (provided by applicant): After surgery, a short-term change in mental status (delirium) is frequent complication that is under- recognized and can affect patient's long-term ability to live at home. This study uses state-of-the-art brain imaging to compare long-term brain changes in patients with and without delirium after surgery. If the hypotheses are confirmed, this will alter our fundamental understanding of delirium as a short-term disorder and future studies can use imaging to prevent, identify, and treat delirium.

描述（由申请人提供）： 手术后，精神状态的短期变化（谵妄）是常见的并发症，但认识不足，可能影响患者在家中的长期生活能力。这项研究使用最先进的脑成像技术来比较手术后有和没有谵妄的患者的长期脑变化。如果这些假设得到证实，这将改变我们对谵妄作为一种短期疾病的基本理解，未来的研究可以使用成像来预防，识别和治疗谵妄。