Biomechanical Properties of the Transverse Carpal Ligament

腕横韧带的生物力学特性

• 批准号: 7303109
• 负责人: Zong-Ming Li
• 金额: $ 7.43万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7303109
• 关键词: Activities of Daily Living; American; Behavior; Biomechanics; Biomedical Engineering; Carpal Tunnel Syndrome; Clinical Trials; Computer Simulation; Condition; Data; Development; Disease; Elements; Etiology; General Population; Goals; Hand; Health Care Costs; Invasive; Investigation; Knowledge; Ligaments; Mechanics; Methods; Modeling; Operative Surgical Procedures; Pathogenesis; Play; Prevalence; Prevention strategy; Principal Investigator; Procedures; Productivity; Property; Public Health; Recurrence; Research; Residual state; Role; Specimen; Standards of Weights and Measures; Stretching; Techniques; Testing; United States; Validation; improved; morphometry; novel; programs; tool

DESCRIPTION (provided by applicant): Carpal tunnel syndrome (CTS) is the most prominent hand disorder and has an immense negative impact on national health care cost, worker productivity, and activities of daily living. Despite its increasing prevalence and public health burden, our understanding of CTS is rather limited and our treatment to CTS awaits improvement. The objective of this project is to elucidate the mechanical properties of the transverse carpal ligament (TCL), to comprehend the implication of TCL mechanics to CTS, and to use our findings to guide the development of alternative CTS treatments. We will achieve the objective using complementary experimental and theoretical approaches. Experimentally, we will investigate the material properties of the TCL and the structural properties of the carpal tunnel using cadaveric specimens. The experimental data will allow for the creation and validation of a finite element model of the carpal tunnel. The validated model will provide a valuable tool for the prediction of carpal tunnel mechanics and pathomechanics under numerous anatomical configurations and biomechanical boundary conditions. Our central hypothesis is that the mechanics of the TCL can be exploited for the development of a minimally invasive surgical treatment of CTS. Specifically, we will test the hypotheses that the carpal tunnel can be substantially expanded by stretching the TCL without compromising the structural integrity of the carpal tunnel, and that permanent residual expansion of the carpal tunnel can be obtained after an extended period of loading on the TCL. The specific aims of this project are (1) to characterize the material properties of the TCL by tensile testing, (2) to examine the expansion and creep behaviors of the carpal tunnel by stretching the TCL from within the carpal tunnel, and (3) to establish a computational model for the determination of carpal tunnel morphometry under various anatomical configurations and loading conditions. Our study represents a novel bioengineering approach to an enhanced management of CTS. The results of our investigation will aid the discovery of alternative pathogeneses of CTS, and the development of alternative treatments of CTS. Our long-term goal is to scientifically understand the mechanics and pathomechanics of the carpal tunnel entity and its relevance to CTS, and help provide strategies for the prevention, assessment, and treatment of CTS.

描述（由申请人提供）： 腕管综合症（CTS）是最突出的手部疾病，对国家医疗保健成本、工人生产力和日常生活活动产生巨大的负面影响。尽管其患病率和公共卫生负担不断增加，但我们对 CTS 的了解相当有限，并且我们对 CTS 的治疗有待改进。 该项目的目的是阐明腕横韧带 (TCL) 的力学特性，理解 TCL 力学对 CTS 的影响，并利用我们的发现来指导替代 CTS 治疗的开发。我们将使用互补的实验和理论方法来实现这一目标。在实验上，我们将使用尸体标本研究 TCL 的材料特性和腕管的结构特性。实验数据将用于创建和验证腕管的有限元模型。经过验证的模型将为预测多种解剖结构和生物力学边界条件下的腕管力学和病理力学提供有价值的工具。我们的中心假设是，TCL 的机制可用于开发 CTS 的微创手术治疗。具体来说，我们将测试这样的假设：通过拉伸 TCL 可以使腕管显着扩张，而不损害腕管的结构完整性，并且在 TCL 上长时间加载后可以获得腕管的永久残余扩张。该项目的具体目标是（1）通过拉伸测试表征 TCL 的材料特性，（2）通过从腕管内拉伸 TCL 来检查腕管的膨胀和蠕变行为，以及（3）建立计算模型，用于确定各种解剖结构和负载条件下的腕管形态测量。 我们的研究代表了一种增强 CTS 管理的新型生物工程方法。我们的研究结果将有助于发现 CTS 的替代发病机制，并开发 CTS 的替代治疗方法。我们的长期目标是科学地了解腕管实体的力学和病理力学及其与 CTS 的相关性，并帮助为 CTS 的预防、评估和治疗提供策略。