Limited Access Dataset: ACTIVE Study Phase II

描述（由申请人提供）：本R 03的目的是为1998-2001年进行的独立和重要老年人高级认知训练（ACTIVE）试验的第三次和第五次年度评估创建有限访问数据集。这项工作的资金没有包括在进行审判的裁决中。之前的R 03奖（AG 22338）资助了基线、测试后立即以及第一次和第二次年度评估的有限访问数据集的创建。这些数据集分两个阶段由密歇根大学国家老龄问题计算机化数据档案馆存档（http：//www.icpsr.umich.edu/NACDA）。第三次和第五次年度评估的有限访问数据集将与NACDA一起存档，作为初始数据集的补充。此应用程序是直接响应NIA的R 03计划公告PA-06-02“社会行为数据分析和老化”。ACTIVE是一项由NIA和NINR申办的随机对照试验，在6个现场（伯明翰大学、波士顿希伯来老年康复中心、印第安纳州大学、约翰霍普金斯大学、宾夕法尼亚州立大学和韦恩州立大学）进行。主要目的是测试三种认知干预措施在改善老年人基本认知指标和认知要求日常活动指标（例如，食物准备、驾驶、药物使用、财务管理）。共有2，832人参加了试验。ACTIVE的五年结果显示，干预对认知功能的影响具有持久性，并将这些影响转移到维持IADL功能。由于其规模和精心开发的严谨性，其数据集为研究人员提供了大量的二次分析机会。将对ACTIVE数据集进行修改，以确保所有ACTIVE参与者和机构的隐私保护。重新格式化的数据集将以只读格式存档在CD ROM中，并附有所有相关的测量工具、变量说明和汇总表以及综合文件。这项工作将由新英格兰研究所（试验协调中心）执行。项目叙述：ACTIVE研究已经并将产生具有重大公共利益、公共卫生意义和科学价值的结果。ACTIVE干预措施很好地融入了几项全国性的卫生倡议（例如，美国国立卫生研究院的“健康大脑”倡议和阿尔茨海默病协会的“保持你的大脑”，其目标是降低失去独立性的风险。各大学和调查人员对目前存档的数据集兴趣很大，并加以利用。该项目将使研究数据的其余部分可供公众使用。

DESCRIPTION (provided by applicant): The Aim of this R03 is to create Limited Access Datasets for the third and fifth annual assessments for the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial, conducted from 1998-2001. Funds for this work were not included in the award for conduct of the trial. A previous R03 award (AG22338) funded the creation of the Limited Access Datasets for baseline, immediate post-test and first and second annual assessments. These datasets are being archived in two stages with the National Archive of Computerized Data in Aging (NACDA) at the University of Michigan (http://www.icpsr.umich.edu/NACDA). The Limited Access Dataset for the third and fifth annual assessments will be archived with NACDA as supplements to the initial dataset. This application is directly responsive to NIA's R03 Program Announcement PA-06-02 "Sociobehavioral Data Analysis and Archiving in Aging". ACTIVE was a randomized, controlled trial, sponsored by NIA and NINR, conducted at 6 field sites (University of Alabama-Birmingham; Hebrew Rehabilitation Center for the Aged, Boston; Indiana University; Johns Hopkins University; Pennsylvania State University; and Wayne State University. The primary objective was to test the effectiveness and durability of three cognitive interventions in improving elders' performance on basic measures of cognition and on measures of cognitively demanding daily activities (e.g., food preparation, driving, medication use, financial management). A total of 2,832 persons were enrolled in the trial. The five- year results of ACTIVE show durability of intervention effects on cognitive function and transfer of these effects to maintenance of IADL function. Because of its size and the carefully developed rigor, its datasets offer to investigators a wealth of opportunities for secondary analyses. Modifications will be made to ACTIVE datasets to ensure privacy protection for all ACTIVE participants and institutions. The reformatted datasets will be archived in read-only format on CD ROM and accompanied by all related measurement instruments, variable descriptions and summary tables, and comprehensive documentation. This work will be performed by the New England Research Institutes, the Coordinating Center for the trial. PROJECT NARRATIVE: The ACTIVE study has and will produce results of substantial public interest, public health significance, and scientific value. The ACTIVE interventions fit well into several nationwide health initiatives (e.g., NIH's "Healthy Brain" initiative, and the Alzheimer Association's "Maintain your Brain), with their goals of lowering risk for loss of independence. There has been a high level of interest in and use of the currently archived datasets by universities and investigators. This project will make the remainder of the study data available for public use.