Limited Access Dataset: ACTIVE Study Phase II

描述（由申请人提供）：本R03的目的是为1998-2001年进行的独立和重要老年人高级认知训练（ACTIVE）试验的第三和第五次年度评估创建有限访问数据集。这项工作的资金不包括在进行试验的奖励中。之前的R03奖（AG22338）资助了有限访问数据集的创建，用于基线，即时后测试以及第一和第二次年度评估。这些数据集分两个阶段被密歇根大学的国家老龄化计算机数据档案馆（NACDA）存档（http://www.icpsr.umich.edu/NACDA）。第三次和第五次年度评估的有限访问数据集将作为初始数据集的补充在NACDA存档。本应用程序直接响应NIA的R03项目公告PA-06-02“老龄化中的社会行为数据分析和存档”。ACTIVE是一项随机对照试验，由NIA和NINR赞助，在6个地点进行（阿拉巴马大学-伯明翰分校、希伯来老年人康复中心、波士顿、印第安纳大学、约翰霍普金斯大学、宾夕法尼亚州立大学和韦恩州立大学）。主要目的是测试三种认知干预措施在改善老年人基本认知指标和认知要求高的日常活动指标（如准备食物、驾驶、用药、财务管理）方面的表现的有效性和持久性。共有2,832人参加了试验。ACTIVE的5年结果显示干预对认知功能的影响的持久性和这些影响转移到维持IADL功能。由于它的规模和精心开发的严谨性，它的数据集为调查人员提供了大量的二次分析机会。将对ACTIVE数据集进行修改，以确保所有ACTIVE参与者和机构的隐私得到保护。重新格式化的数据集将以只读格式存档在CD ROM上，并附有所有相关的测量仪器、变量描述和汇总表以及综合文件。这项工作将由试验协调中心新英格兰研究所进行。项目描述：ACTIVE研究已经并将产生具有重大公共利益、公共卫生意义和科学价值的结果。ACTIVE干预措施很好地适应了几个全国性的健康倡议（例如，美国国立卫生研究院的“健康大脑”倡议，以及阿尔茨海默病协会的“维护你的大脑”），其目标是降低丧失独立性的风险。大学和研究人员对当前存档的数据集有很高的兴趣和使用。该项目将使其余的研究数据可供公众使用。

DESCRIPTION (provided by applicant): The Aim of this R03 is to create Limited Access Datasets for the third and fifth annual assessments for the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial, conducted from 1998-2001. Funds for this work were not included in the award for conduct of the trial. A previous R03 award (AG22338) funded the creation of the Limited Access Datasets for baseline, immediate post-test and first and second annual assessments. These datasets are being archived in two stages with the National Archive of Computerized Data in Aging (NACDA) at the University of Michigan (http://www.icpsr.umich.edu/NACDA). The Limited Access Dataset for the third and fifth annual assessments will be archived with NACDA as supplements to the initial dataset. This application is directly responsive to NIA's R03 Program Announcement PA-06-02 "Sociobehavioral Data Analysis and Archiving in Aging". ACTIVE was a randomized, controlled trial, sponsored by NIA and NINR, conducted at 6 field sites (University of Alabama-Birmingham; Hebrew Rehabilitation Center for the Aged, Boston; Indiana University; Johns Hopkins University; Pennsylvania State University; and Wayne State University. The primary objective was to test the effectiveness and durability of three cognitive interventions in improving elders' performance on basic measures of cognition and on measures of cognitively demanding daily activities (e.g., food preparation, driving, medication use, financial management). A total of 2,832 persons were enrolled in the trial. The five- year results of ACTIVE show durability of intervention effects on cognitive function and transfer of these effects to maintenance of IADL function. Because of its size and the carefully developed rigor, its datasets offer to investigators a wealth of opportunities for secondary analyses. Modifications will be made to ACTIVE datasets to ensure privacy protection for all ACTIVE participants and institutions. The reformatted datasets will be archived in read-only format on CD ROM and accompanied by all related measurement instruments, variable descriptions and summary tables, and comprehensive documentation. This work will be performed by the New England Research Institutes, the Coordinating Center for the trial. PROJECT NARRATIVE: The ACTIVE study has and will produce results of substantial public interest, public health significance, and scientific value. The ACTIVE interventions fit well into several nationwide health initiatives (e.g., NIH's "Healthy Brain" initiative, and the Alzheimer Association's "Maintain your Brain), with their goals of lowering risk for loss of independence. There has been a high level of interest in and use of the currently archived datasets by universities and investigators. This project will make the remainder of the study data available for public use.