Preserving Function in Rural Breast Cancer Patients Undergoing Chemotherapy

农村乳腺癌化疗患者的功能保留

• 批准号: 7280290
• 负责人: MARK T HEGEL
• 金额: $ 7.76万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7280290
• 关键词: Activities of Daily Living; Adjuvant; Adverse effects; Aerobic Exercise; Affect; Applications Grants; Behavioral Research; Cancer Control; Cancer Patient; Cancer Survivor; Caring; Clinical Trials; Comprehensive Cancer Center; Controlled Study; Data; Distress; Early Intervention; Educational Intervention; Enrollment; Family; Feasibility Studies; Goals; Grant; Guided imagery; Health Services Accessibility; Impairment; Improve Access; Institute of Medicine (U.S.); Intervention; Investigation; Lead; Life; Location; Malignant Neoplasms; Manuals; Measures; Medical Surveillance; Methods; Modeling; NIH Program Announcements; National Research Council; Newly Diagnosed; Outcome; Outcome Measure; Patients; Physical therapy; Prevention; Problem Solving; Public Health; Quality of life; Randomized; Randomized Controlled Trials; Rate; Recommendation; Recovery; Rehabilitation therapy; Relaxation; Risk; Rural; Self Care; Social Work; Survivors; Telephone; Testing; Time; Training; Treatment Protocols; Upper arm; Week; Woman; base; cancer therapy; chemotherapy; cost; cost effective; experience; functional disability; functional outcomes; functional status; improved; improved functioning; malignant breast neoplasm; psychosocial; rural area; satisfaction; size; symptom management

DESCRIPTION (provided by applicant): Breast cancer patients experience functional limitations related to the cancer and treatment side effects. Early functional limitations affect short- and long-term quality of life, and may lead to long-term complications. Patients living in rural areas are at particular risk because they do not have easy access to services. Therefore, early intervention is indicated to have an impact on the overall public health. Problem solving training (PST) is a standardized manual driven intervention that may be ideally suited to assist breast cancer patients to preserve their valued activities and to comply with recommended symptom management regimens (e.g., physical therapy, aerobic exercise and relaxation/guided imagery) that improve function. Telephone-based PST provided from a centralized location (such as the comprehensive cancer center) may improve access and outcomes in a cost-effective manner. We propose to conduct a feasibility study of a PST intervention with 30 rural breast cancer patients undergoing adjuvant treatment randomly assigned to PST or to usual care. The intervention group will receive weekly phone-based PST sessions for six consecutive weeks. The specific aims of this R03 small grant application are to: 1) Test the feasibility of enrolling and retaining newly diagnosed breast cancer patients in a clinical trial to assess telephone-based PST. 2) Collect preliminary data on outcome measures of function to determine effect size estimates that will inform power analyses for a full scale randomized controlled study. Primary outcome measures will be acceptance rates for enrollment in the study, retention rates across both intervention arms, and satisfaction levels with the PST intervention. Assessments will be conducted at baseline, and at six weeks (end of PST intervention) and 3 months following baseline. The long-term goal of this line of investigation is to develop practical, widely applicable rehabilitation models of care to preserve function and decrease distress in cancer patients undergoing treatment.

描述（由申请人提供）：乳腺癌患者会经历与癌症和治疗副作用相关的功能限制。早期功能限制会影响短期和长期的生活质量，并可能导致长期并发症。生活在农村地区的患者面临特别的风险，因为他们不容易获得服务。因此，早期干预对整体公共卫生产生影响。问题解决训练 (PST) 是一种标准化的人工驱动干预措施，非常适合帮助乳腺癌患者保留其有价值的活动并遵守改善功能的推荐症状管理方案（例如物理治疗、有氧运动和放松/引导意象）。从集中地点（例如综合癌症中心）提供的基于电话的 PST 可以以具有成本效益的方式改善访问和结果。我们建议对 30 名农村乳腺癌患者进行 PST 干预的可行性研究，这些患者接受随机分配至 PST 或常规护理的辅助治疗。干预组将连续六周每周接受基于电话的 PST 会议。该 R03 小额赠款申请的具体目标是： 1) 测试在临床试验中招募和保留新诊断的乳腺癌患者以评估基于电话的 PST 的可行性。 2) 收集有关功能结果测量的初步数据，以确定效应大小估计值，为全面随机对照研究的功效分析提供信息。主要结果指标是研究的入学接受率、两个干预组的保留率以及对 PST 干预的满意度。评估将在基线、基线后六周（PST 干预结束）和 3 个月时进行。该研究的长期目标是开发实用、广泛适用的康复护理模式，以保留接受治疗的癌症患者的功能并减少痛苦。

项目成果

Reliability and validity of the valued activity inventory for adults with cancer.

成人癌症患者有价值的活动清单的可靠性和有效性。

• DOI: 10.3928/15394492-20110623-02
• 发表时间: 2012
• 期刊: OTJR : occupation, participation and health
• 作者: Lyons,KathleenDoyle;Hegel,MarkT;Hull,JayG;Li,Zhongze;Balan,Stefan;Bartels,Stephen
• 通讯作者: Bartels,Stephen