Veterinary Comparative Respiratory Society 2008 Symposium

兽医比较呼吸学会2008年研讨会

• 批准号: 7540106
• 负责人: MICHAEL S DAVIS
• 金额: $ 1.5万
• 依托单位: OKLAHOMA STATE UNIVERSITY STILLWATER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7540106
• 关键词: Animal Model; Animals; Biomedical Research; Canis familiaris; Cattle; Collaborations; Communities; Complex; Data; Development; Disease; Domestic Animals; Equus caballus; Felis catus; Functional disorder; Funding; Genes; Genome; Hand; Human; International; Knowledge; Laboratories; Livestock; Lung diseases; Modeling; Physiological; Physiology; Population; Proteins; Purpose; Recording of previous events; Relative (related person); Research; Research Personnel; Respiratory System; Respiratory physiology; Rodent; Rodent Model; Role; Science; Societies; Testing; Time; Translational Research; base; comparative; cost; experience; human disease; insight; programs; respiratory; scientific organization; symposium; tool

DESCRIPTION (provided by applicant): Biomedical use of animal models continues to provide valuable insights into the physiology and pathophysiology of the mammalian respiratory tract, and various animal models have provided key advances in the understanding and treatment of human respiratory disease. Laboratory rodents represent the largest proportion of animals used in human biomedical research, with their value arising both from their economy as well as from the ability of researchers to manipulate the genome of these animals to identify the role of specific genes or gene products. At the same time, the value of domestic animals such as dogs, cats, horses, and livestock is increasingly appreciated by the biomedical research community due to their physiological and teleological similarity to humans, as well as the natural occurrence of diseases analogous to important human diseases. Thus, these large animal models are unmatched for their value in translational research. However, due to the cost and difficulty of employing these models in human biomedical research, they are underutilized as research tools. The purpose of this program is to present the current data regarding the more common and well-characterized domestic animal models of human respiratory disease in the context of their strengths and weaknesses relative to laboratory rodent models as well as the relevant human population. Speakers will be selected based on their first-hand experience in using these models as basic and/or translational tools for human-oriented biomedical research. The program will conclude with a critical discussion on the possible strategies for making these models more accessible to the biomedical community, and biomedical research funding more accessible to those investigators seeking to use these models for the advancement of biomedical knowledge. The symposium will be co-sponsored by the Veterinary Comparative Respiratory Society, a scientific organization with a 25 year history of holding annual international scientific conferences on respiratory physiology and pathophysiology of domestic animals. The conference will emphasize the development of interinstitutional collaborations and the integration of young investigators into the biomedical science community. Understanding complex human disease and the development and testing of suitable treatments requires the use of complex animal models of those diseases. Such models are typically domestic animals such as dogs, cats, horses, and cattle, in which similar diseases occur naturally. This symposium will review the current knowledge and practical challenges of these models in order to make them more accessible to the biomedical research community.

描述(由申请人提供)： 动物模型的生物医学应用继续为哺乳动物呼吸道的生理学和病理生理学提供有价值的见解，各种动物模型在理解和治疗人类呼吸道疾病方面取得了关键进展。实验室啮齿动物是人类生物医学研究中使用的最大比例的动物，它们的价值来自于它们的经济以及研究人员操纵这些动物的基因组以确定特定基因或基因产物的作用的能力。与此同时，狗、猫、马和牲畜等家畜的价值越来越受到生物医学研究界的重视，因为它们在生理和目的上与人类相似，而且自然会发生类似于人类重要疾病的疾病。因此，这些大型动物模型在翻译研究中的价值是无与伦比的。然而，由于在人类生物医学研究中使用这些模型的成本和难度，它们作为研究工具没有得到充分的利用。本计划的目的是介绍关于人类呼吸道疾病较常见和特征良好的家养动物模型的当前数据，以及它们相对于实验室啮齿动物模型和相关人类种群的优势和劣势。演讲者将根据他们在使用这些模型作为面向人类的生物医学研究的基本和/或翻译工具方面的第一手经验来选择。该计划将以关键的讨论结束，讨论使这些模型更容易为生物医学界所用的可能战略，以及那些寻求使用这些模型来促进生物医学知识发展的研究人员更容易获得生物医学研究资金。这次研讨会将由兽医比较呼吸学会联合主办，该学会是一个有25年历史的科学组织，每年举办一次关于家畜呼吸生理学和病理生理学的国际科学会议。会议将强调机构间合作的发展和年轻研究人员融入生物医学科学界。了解复杂的人类疾病以及开发和测试合适的治疗方法需要使用这些疾病的复杂动物模型。这类模型通常是家养动物，如狗、猫、马和牛，在这些动物中，类似的疾病自然发生。这次研讨会将回顾这些模型的当前知识和实践挑战，以使它们更容易为生物医学研究界所接受。