Image-based Measures for Osteoarthritis

基于图像的骨关节炎测量

• 批准号: 7546954
• 负责人: David John Hunter
• 金额: $ 2.82万
• 依托单位: NEW ENGLAND BAPTIST HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-20 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7546954
• 关键词: Address; Analgesics; Applied Research; Austria; Boston; Clinical; Communities; Consensus; Degenerative polyarthritis; Development; Diagnostic radiologic examination; Disease; Educational workshop; Funding; Future; Goals; Image; Industry; Investments; Joints; Magnetic Resonance Imaging; Manufacturer Name; Measures; Natural History; Pharmaceutical Preparations; Pharmacologic Substance; Process; Replacement Arthroplasty; Research; Research Personnel; Resources; Science; Scientist; Structure; Suggestion; Therapeutic; Time; Travel; abstracting; base; cost; day; in vivo; instrument; optimism; posters; programs; research and development; soft tissue; symposium

DESCRIPTION (provided by applicant): In the late 1980s, the application of the superb soft tissue contrast of MRI to image the joint led to great optimism that inroads to understanding the natural history of, and applying therapeutics to, osteoarthritis would be quickly forthcoming. However, nearly 20 years later, much about clinical OA has yet to be discovered, there is yet to be a successful trial for a disease modifying OA drug (DMOAD), and radiography is still the mainstay of imaging of OA. The goal of the proposed workshop is to bring together the communities of basic osteoarthritis researchers, orthopedists and rheumatologists, imaging scientists, instrument manufacturers, and pharmaceutical and regulatory representatives to delineate what the pressing questions are in OA research, what imaging science has contributed thus far, what questions imaging can start to address, and what resources and research agenda going forward are needed to accomplish this. In addition to the presentations and podium discussions, there will be two poster sessions from submitted abstracts meant to further elucidate the pressing questions from the community. The workshop comes at a critical time in OA research. OA is a clinical disease where the mainstay of current management is analgesic medication and total joint replacement. Efforts to develop agents to slow, halt or reverse the disease process have been slowed by unresponsive measures of the disease process. Unprecedented investment (both industry and federally sponsored) is currently underway in OA aimed at addressing this pressing concern and developing new and responsive imaging markers. However, there is little consensus on which structures in the joint to image, how to image these structures, and how to measure these changes. The proposed conference will facilitate this dialogue in an effort both to promote appropriate marker development, and in the absence of current measures, provide suggestions for future research agendas. It follows a highly successful 1st Annual Workshop on Imaging Based Measures of Osteoarthritis held in Salzburg, Austria in June 2007 where 130 registrants attended a 3 day workshop to initiate this much needed dialogue. Long Term Objective: To promote applied research and development to applications of in vivo imaging of osteoarthritis. Specific Short Term Objective: To provide funds for estimated costs for travel and meeting registration for scientific program committee and young investigators to attend the 2nd Annual Workshop on Imaging Based Measures on Osteoarthritis from June 25th to 28th 2008 in Boston, MA USA. The goal of the proposed workshop is to bring together the communities of basic osteoarthritis researchers, orthopedists and rheumatologists, imaging scientists, instrument manufacturers, and pharmaceutical and regulatory representatives to delineate what the pressing questions are in OA research, what imaging science has contributed thus far, what questions imaging can start to address, and what resources and research agenda going forward are needed to accomplish this.

描述（由申请人提供）：在 20 世纪 80 年代末，应用 MRI 卓越的软组织对比度对关节进行成像带来了极大的乐观情绪，人们对骨关节炎的自然史的理解和应用治疗方法的了解很快就会出现。然而，近 20 年后，关于临床 OA 的许多内容尚未被发现，尚未成功试验改善 OA 药物 (DMOAD)，而放射线照相仍然是 OA 影像学的支柱。拟议研讨会的目标是将基础骨关节炎研究人员、骨科医生和风湿病学家、影像科学家、仪器制造商以及制药和监管代表聚集在一起，描述 OA 研究中的紧迫问题、影像科学迄今为止做出的贡献、影像可以开始解决哪些问题，以及实现这一目标需要哪些资源和研究议程。除了演讲和讲台讨论之外，还将举行两次提交摘要的海报会议，旨在进一步阐明社区的紧迫问题。此次研讨会恰逢 OA 研究的关键时刻。 OA是一种临床疾病，目前治疗的主要方法是镇痛药物和全关节置换术。由于对疾病过程的反应迟钝，开发减缓、停止或逆转疾病过程的药物的努力已经放缓。目前，OA 领域正在进行前所未有的投资（包括行业和联邦政府资助），旨在解决这一紧迫问题并开发新的响应性成像标记物。然而，对于关节中的哪些结构需要成像、如何对这些结构进行成像以及如何测量这些变化，目前还没有达成共识。拟议的会议将促进这种对话，以促进适当的标记开发，并在缺乏当前措施的情况下，为未来的研究议程提供建议。在此之前，2007 年 6 月在奥地利萨尔茨堡举办的第一届骨关节炎影像测量年度研讨会非常成功，130 名注册者参加了为期 3 天的研讨会，以启动这一急需的对话。长期目标：促进骨关节炎体内成像应用的应用研究和开发。具体短期目标：为科学项目委员会和年轻研究者参加 2008 年 6 月 25 日至 28 日在美国马萨诸塞州波士顿举行的第二届骨关节炎影像测量年度研讨会提供差旅费和会议注册费用。拟议研讨会的目标是将基础骨关节炎研究人员、骨科医生和风湿病学家、影像科学家、仪器制造商以及制药和监管代表聚集在一起，描述 OA 研究中的紧迫问题、影像科学迄今为止做出的贡献、影像可以开始解决哪些问题，以及实现这一目标需要哪些资源和研究议程。