Signal Transduction Through Tetraspanins and Other Multi-Protein Cell Surface Com

通过四跨膜蛋白和其他多蛋白细胞表面蛋白进行信号转导

• 批准号: 7479527
• 负责人: Christopher S. Stipp
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7479527
• 关键词: Adhesions; Binding; Blood Vessels; Brain; Cell Communication; Cell Surface Proteins; Cell Surface Receptors; Cell physiology; Cell surface; Cells; Collaborations; Communities; Complex; Development; Disease; Endopeptidases; Epithelial Cell Proliferation; Equilibrium; Fostering; Funding; Genetic; Goals; Growth Factor; HIV Budding; Hepatitis C virus; Immunity; Immunologist; Maintenance; Malaria; Malignant Neoplasms; Membrane; Membrane Proteins; Mental Retardation; Morphology; Neoplasm Metastasis; Peptide Hydrolases; Photoreceptors; Play; Process; Protein Family; Proteins; Range; Reagent; Research; Research Personnel; Role; Signal Transduction; Syndrome; Universities; cell motility; cell type; egg; human PHEMX protein; neoplastic cell; parasite invasion; receptor; sperm cell; symposium; synaptogenesis; trafficking

DESCRIPTION (provided by applicant): We request partial funding for a FASEB Summer Research Conference entitled, "Signal Transduction through Tetraspanins and Other Multi-Protein Complexes," to be held June 22-27, 2008 at the Omni New Haven Hotel at Yale University. Tetraspanins play important roles in a wide range of fundamental cellular processes including motility, adhesion, invasion, cell-cell interactions, fusion, polarity, and receptor trafficking. Genetic evidence has uncovered critical functions for tetraspanins in immunity, sperm egg fusion, brain development, control of cell proliferation, epithelial integrity, synapse formation, and the maintenance of photoreceptor morphology. In addition, tetraspanins have emerged as important regulators in a variety of pathological settings, including tumor cell metastasis, mental retardation syndromes, hepatitis C virus binding, HIV budding, and malaria parasite invasion. Tetraspanins participate in such a broad range of processes because they act as cell surface organizers, assembling multi-protein complexes containing a diverse but specific set of cell surface receptors, Ig super family proteins, and membrane- bound growth factors and proteases. As a result, the tetraspanin researchers are extraordinarily diverse and include basic cell biologists, vascular biologists, developmental biologists, cancer biologists, immunologists, virologists, membrane biologists, and neurobiologists. The goals of the 2008 FASEB Tetraspanin Conference are (i) to provide a common forum for tetraspanin researchers who, owing to the diversity of the field, might otherwise be unlikely to attend the same professional meetings, (ii) to create new connections between established tetraspanin researchers and researchers studying tetraspanin partners in other contexts and, (iii) to foster a broader research community centered around the roles of membrane organizing proteins in signal transduction. To accomplish these goals, the meeting will have a balanced, interdisciplinary agenda with nine main sessions in which the common theme of cell surface organization will be explored in the context of many different cell types and disease states. The FASEB Tetraspanin Conference will thus provide a unique opportunity for scientific interaction, the establishment of new collaborations, and the exchange of valuable research reagents, all of which are expected to increase the pace of discovery in the biomedically important field of tetraspanin research.

描述（由申请人提供）：我们要求针对2008年6月22日至27日在耶鲁大学的Omni New Haven Hotel举行的FaseB夏季研究会议的题为“通过四叠蛋白和其他多蛋白质复合物的信号转导信号”。四跨质蛋白在广泛的基本细胞过程中起着重要作用，包括运动，粘附，侵袭，细胞 - 细胞相互作用，融合，极性和受体运输。遗传证据已经发现了四叠蛋白酶在免疫，精子融合，脑发育，细胞增殖，上皮完整性，突触形成以及光感受器形态的维持方面的关键功能。此外，在各种病理环境中，四叠蛋白酶已成为重要的调节剂，包括肿瘤细胞转移，智力障碍综合征，乙型肝炎病毒结合，HIV芽芽和疟原虫寄生虫侵袭。四跨果素参与了如此广泛的过程，因为它们充当细胞表面组织者，组装了包含多种但特定的细胞表面受体，IG超级家族蛋白以及膜结合生长因子和蛋白酶的多蛋白络合物。结果，四翼生研究人员非常多样化，包括基本的细胞生物学家，血管生物学家，发育生物学家，癌症生物学家，免疫学家，病毒学家，膜生物学家和神经生物学家。 2008年FASEB四叠素蛋白会议的目标是（i）为四叠素研究人员提供一个共同的论坛，否则，由于该领域的多样性，他们可能不太可能参加相同的专业会议，（ii）建立新的连接，以建立既定的四翼胺研究人员与研究跨越构造的研究人员之间的既定型四翼胺研究人员，以围绕其他上下文的构建，以围绕其他构图（III II II II）（III II II）（III II II II）（foster forser forser），这是III III（III II II II），该组织是福特（IIII）的融合。信号转导中的蛋白质。为了实现这些目标，会议将有一个平衡，跨学科的议程，其中九个主要会议将在许多不同的细胞类型和疾病状态的背景下探索细胞表面组织的共同主题。因此，FASEB四翼胺会议将为科学互动，新合作的建立以及有价值的研究试剂的交换提供独特的机会，所有这些试剂均应提高四面质蛋白研究的生物医学重要领域的发现速度。