Signal Transduction Through Tetraspanins and Other Multi-Protein Cell Surface Com

描述（由申请人提供）：我们申请FASEB夏季研究会议的部分资金，题为“通过四蛋白蛋白和其他多蛋白复合物的信号转导”，将于2008年6月22日至27日在耶鲁大学Omni纽黑文酒店举行。四联蛋白在广泛的基本细胞过程中发挥重要作用，包括运动、粘附、侵袭、细胞-细胞相互作用、融合、极性和受体运输。遗传证据已经揭示了四联蛋白在免疫、精卵融合、大脑发育、细胞增殖控制、上皮完整性、突触形成和维持光感受器形态等方面的关键功能。此外，在多种病理环境中，包括肿瘤细胞转移、智力迟钝综合征、丙型肝炎病毒结合、艾滋病毒出芽和疟疾寄生虫入侵，四蛋白蛋白已成为重要的调节因子。四联蛋白参与了如此广泛的过程，因为它们作为细胞表面组织者，组装包含多种但特定的细胞表面受体、Ig超家族蛋白、膜结合生长因子和蛋白酶的多蛋白复合物。因此，四联蛋白的研究人员非常多样化，包括基础细胞生物学家、血管生物学家、发育生物学家、癌症生物学家、免疫学家、病毒学家、膜生物学家和神经生物学家。2008年FASEB四联蛋白会议的目标是：(1)为四联蛋白研究人员提供一个共同的论坛，这些研究人员由于该领域的多样性，可能不太可能参加相同的专业会议；(2)在已建立的四联蛋白研究人员和在其他背景下研究四联蛋白的研究人员之间建立新的联系；(3)以膜组织蛋白在信号转导中的作用为中心，建立一个更广泛的研究社区。为了实现这些目标，会议将有一个平衡的跨学科议程，包括九个主要会议，其中细胞表面组织的共同主题将在许多不同细胞类型和疾病状态的背景下进行探索。因此，FASEB Tetraspanin会议将为科学互动、建立新的合作和交换有价值的研究试剂提供一个独特的机会，所有这些都有望加快Tetraspanin研究这一重要生物医学领域的发现步伐。

DESCRIPTION (provided by applicant): We request partial funding for a FASEB Summer Research Conference entitled, "Signal Transduction through Tetraspanins and Other Multi-Protein Complexes," to be held June 22-27, 2008 at the Omni New Haven Hotel at Yale University. Tetraspanins play important roles in a wide range of fundamental cellular processes including motility, adhesion, invasion, cell-cell interactions, fusion, polarity, and receptor trafficking. Genetic evidence has uncovered critical functions for tetraspanins in immunity, sperm egg fusion, brain development, control of cell proliferation, epithelial integrity, synapse formation, and the maintenance of photoreceptor morphology. In addition, tetraspanins have emerged as important regulators in a variety of pathological settings, including tumor cell metastasis, mental retardation syndromes, hepatitis C virus binding, HIV budding, and malaria parasite invasion. Tetraspanins participate in such a broad range of processes because they act as cell surface organizers, assembling multi-protein complexes containing a diverse but specific set of cell surface receptors, Ig super family proteins, and membrane- bound growth factors and proteases. As a result, the tetraspanin researchers are extraordinarily diverse and include basic cell biologists, vascular biologists, developmental biologists, cancer biologists, immunologists, virologists, membrane biologists, and neurobiologists. The goals of the 2008 FASEB Tetraspanin Conference are (i) to provide a common forum for tetraspanin researchers who, owing to the diversity of the field, might otherwise be unlikely to attend the same professional meetings, (ii) to create new connections between established tetraspanin researchers and researchers studying tetraspanin partners in other contexts and, (iii) to foster a broader research community centered around the roles of membrane organizing proteins in signal transduction. To accomplish these goals, the meeting will have a balanced, interdisciplinary agenda with nine main sessions in which the common theme of cell surface organization will be explored in the context of many different cell types and disease states. The FASEB Tetraspanin Conference will thus provide a unique opportunity for scientific interaction, the establishment of new collaborations, and the exchange of valuable research reagents, all of which are expected to increase the pace of discovery in the biomedically important field of tetraspanin research.