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2008 Proprotein Processing, Trafficking & Secretion

2008 年前蛋白加工、贩运

基本信息

批准号：
7536669
负责人：
RICHARD E MAINS
金额：
$ 1.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2009-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7536669
关键词：
Alzheimer&apos s Disease Anabolism Area Biochemical Genetics Biological Cells Complex Diabetes Mellitus Discipline Disease Drug Addiction Endocrine Endopeptidases Enzymatic Biochemistry Enzymes Etiology Exocytosis Faculty Financial Support Foundations Golgi Apparatus Homeostasis Malignant Neoplasms Membrane Metalloproteases Molecular Neoplasm Metastasis Neuroendocrine Cell Neurons Neuropeptides Neurosecretory Systems Normal Cell Pathway interactions Peptide Hydrolases Peptide Signal Sequences Peptide Synthesis Peptides Physiological Postdoctoral Fellow Process Prohormone Convertase Proprotein Convertases Proteins Purpose Range Regulation Research Role Scientist Secretory Vesicles Sorting - Cell Movement Stimulus Students System Tissues Yeasts base genetic analysis human disease insight interest intracellular protein transport membrane biogenesis novel peptide hormone protein structure protein transport secretase secretion process symposium trafficking tumor

项目摘要

DESCRIPTION (provided by applicant): The determination of the molecular and cellular bases of endocrine and neuroendocrine homeostasis is evolving into an exciting but complex field, one that provides insight into a staggering array of human diseases. This is in part due to the integration of powerful disciplines ranging from protein structure and enzymology, to protein trafficking, secretion, and the genetic analysis of signaling peptide synthesis in endocrine homeostasis and the etiology of diseases including diabetes, cancer and Alzheimer's as well as the physiological basis of drug addiction. The identification of the enzymes that catalyze the maturation of hundreds of peptide hormones and neuropeptides was a fundamental step in our understanding of the biosynthesis of signaling peptides and proteins. The study of these enzymes has provided a novel platform to integrate proprotein processing with a variety of cell biological studies, including the regulation of protein traffic and membrane biogenesis, especially Golgi dynamics and sorting, and the formation of dense-core secretory granules in stimulus-coupled endocrine and neuroendocrine cells. Analysis of the Prohormone Convertases and the a-Amidating Enzyme has also provided a foundation to study the role of additional membrane-associated enzymatic systems, particularly the matrix metalloproteases and the secretases that control tissue remodeling and membrane shedding in normal cells, as well as their subversion in promoting tumor metastasis and Alzheimer's disease. The cooperative roles of the secretory pathway protease systems together with the underlying cellular trafficking machinery that contribute to these complex, prevalent diseases provides a potent reason to bring together various disciplines to examine each of these factors as rigorously as possible. The Proprotein Processing, Trafficking and Secretion Gordon Research Conference is unique in bringing together scientists from a variety of disciplines whose common interest is in the synthesis, trafficking, processing, secretion, and function of signaling peptides and proteins. The purpose of this application is to request financial support for young faculty, postdoctoral fellows and graduate students to attend this conference, the only one to integrate and consolidate research from many biological disciplines in order to illuminate the roles of the proprotein convertases, the a- amidating enzyme and other processing enzymes involved in endocrine and CNS homoeostasis and the etiology of human disease. This conference integrates these areas of study into recent advances in the regulation of protein traffic, the control of secretion and exocytosis from yeast to neurons, and novel genetic and biochemical approaches to the study of peptide diversity.

描述（由申请人提供）：