Stereoselective Catalysis of the Asymmetric Desymmetrization of Meso Compounds

内消旋化合物不对称去对称化的立体选择性催化

• 批准号: 7394946
• 负责人: Viktorya Aviyente
• 金额: $ 3.25万
• 依托单位: BOGAZICI UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7394946
• 关键词: 3-hydroxybutanal; Amino Acids; Anhydrides; Award; Catalysis; Collaborations; Complement; Computing Methodologies; Country of Turkey; DNA Sequence Rearrangement; Development; Goals; Grant; Hydrogenation; International; Letters; Methods; Modeling; Object Attachment; Process; Proline; Reaction; Reagent; Research; Running; Solid; Structure; Transition Elements; Universities; Work; base; beta-Lactams; catalyst; improved; insight; parent project; professor; tool

DESCRIPTION (provided by applicant): A collaboration between Professor Houk (UCLA) and Professor Aviyente (Bogazici University, Istanbul, Turkey) on modeling the stereoselective catalysis of the desymmetrization of meso compounds is proposed to the Fogarty International Research Collaboration Award. The goal of the parent project (GM-36700), entitled "Stereoselectivities of Synthetic Organic Reactions," is to develop computational methods to explore and predict stereoselective organic reactions. The specific aim of the FIRCA project, entitled "Stereoselective Catalysis of the Asymmetric Desymmetrization of Meso Compounds," is to understand the origins of the stereoselective nonenzymatic ring openings in the desymmetrization of meso cyclic anhydrides. The ultimate goal is to develop a theoretical understanding of the factors that control stereoselectivity and to predict new useful reactions of this type.

描述（由申请人提供）：Houk教授（加州大学洛杉矶分校）和Aviyente教授（Bogazici大学，伊斯坦布尔，土耳其）之间的合作，对内消旋化合物去对称化的立体选择性催化建模，提出了Fogarty国际研究合作奖。母项目（GM-36700）的目标，题为“合成有机反应的立体选择性”，是开发计算方法来探索和预测立体选择性有机反应。FIRCA项目的具体目标是“内消旋化合物的不对称去对称化的立体选择性催化”，目的是了解内消旋环酐去对称化中立体选择性非酶开环的起源。最终目标是发展控制立体选择性的因素的理论理解，并预测这种类型的新的有用的反应。