PHYSIOLOGICAL CHARACTERIZATION OF INDIVIDUALS WITH VARIANTS IN THE HNF-4A PRO

HNF-4A PRO 变异个体的生理特征

• 批准号: 7716720
• 负责人: RICHARD M WATANABE
• 金额: $ 4.57万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-20 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716720
• 关键词: B-Lymphocytes; Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Development; Diabetes Mellitus; Dose; Family member; Financial compensation; Funding; Glucose; Grant; Individual; Infusion procedures; Institution; Insulin; Insulin Resistance; Mexican Americans; Oral; Physiological; Promoter Regions; Purpose; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Variant; Woman; design; intravenous glucose tolerance test; response; time use

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The investigators have found an association between variants in the P2 (B-cell) promoter region of HNF-4A and reduced B-cell compensation for insulin resistance using a cross sectional design in Mexican American women with prior GDM and their family members. The main purpose of the present proposal is to determine whether one of these variants is associated with abnormal dose-response relationships between insulin and glucose and/or accelerated loss of B-cell function over time using oral and intravenous glucose tolerance tests and graded glucose infusions. It is anticipated that this information will help us understand more about how HNF-4A is involved in the development of diabetes and also the mechanisms by which it may be associated with diabetes.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 研究人员发现，HNF-4A的P2（B细胞）启动子区域的变异与胰岛素抵抗的B细胞补偿减少之间存在关联，使用横截面设计，在墨西哥裔美国女性中进行既往GDM及其家庭成员。 本提案的主要目的是使用口服和静脉内葡萄糖耐量试验和分级葡萄糖输注确定这些变体之一是否与胰岛素和葡萄糖之间的异常剂量-反应关系和/或B细胞功能随时间的加速丧失相关。 预计这些信息将有助于我们更多地了解HNF-4A如何参与糖尿病的发展，以及它与糖尿病相关的机制。