PHYSIOLOGIC EFFECTS OF GENETIC VARIATION IN TRANSCRIPTION FACTOR 7-LIKE 2: (B

转录因子 7-LIKE 2 遗传变异的生理效应：（B

• 批准号: 7982143
• 负责人: RICHARD M WATANABE
• 金额: $ 8.23万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7982143
• 关键词: Affect; Blood; Body fat; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; DEXA; DNA; Fasting; Funding; GCG gene; Genetic Transcription; Genetic Variation; Genotype; Goals; Grant; Individual; Institution; Lipids; Non-Insulin-Dependent Diabetes Mellitus; OGTT; Participant; Phenotype; Physical Examination; Physiological; Research; Research Personnel; Resources; Scanning; Series; Single Nucleotide Polymorphism; Source; Structure of beta Cell of islet; Susceptibility Gene; United States National Institutes of Health; Visit; base; human TCF7L2 protein; intravenous glucose tolerance test; non-diabetic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a genotype-based recall study to contrast individuals discordant for specific single nucleotide polymorphism (SNP) in the gene for transcription factor 7-like 2 (TCF7L2). TCF7L2 is a susceptibility gene for type 2 diabetes that appers to affect pancreatic beta-cell function.This study will recall pervious participants of the BetaGene study who are discordant for the SNP rs 12255372 and repeat the series of phenotyping that was performed in the original BetaGene study visit. The purpose of this study it to contrast between the two genotypes groups and to also assess differences in GLP1 concentrations during the oral glucose tolerance test (OGTT). The second goal is to assess whether the temporal change in the phenotypes (current phenotype value - phenotype value at original BeteGene visit ) is different between the two genotypes and whether these changes are altered by body fat. Non-diabetic individuals who previously participated in the BeteGene study are discordant for rs12255372 genotype will be eligible for this study. Paticipants will undergo two GCRC visits. The first visit will consist of physical examination and OGTT. The second visit will consist of an intravenous glucose tolerance test and a DEXA scan. . Fasting blood will be collected for DNA, RNA, and lipids.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项基于基因型的回忆研究，旨在对比转录因子7样2（TCF 7 L2）基因中特定单核苷酸多态性（SNP）不一致的个体。TCF 7 L2是2型糖尿病的易感基因，似乎影响胰腺β细胞功能。本研究将召回BetaGene研究中与SNP rs 12255372不一致的先前参与者，并重复在原始BetaGene研究访视中进行的一系列表型分析。本研究的目的是比较两种基因型组之间的差异，并评估口服葡萄糖耐量试验（OGTT）期间GLP 1浓度的差异。第二个目标是评估两种基因型之间表型的时间变化（当前表型值-初始BeteGene访视时的表型值）是否不同，以及这些变化是否被体脂改变。先前参加BeteGene研究的rs 12255372基因型不一致的非糖尿病个体将有资格参加本研究。患者将接受两次GCRC访视。首次访视包括体格检查和OGTT。第二次访视将包括静脉葡萄糖耐量试验和DEXA扫描。.将采集空腹血液用于DNA、RNA和脂质。