THE EFFECT OF INTRADIALYTIC EXERCISE ON SYMPATHETIC HYPERACTIVITY IN PATIENTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 终末期肾病（ESRD）患者心血管疾病的发病率和死亡率非常高，高血压和交感神经功能亢进肯定有助于心血管事件的增加。本研究的第一部分将检查肌肉失调和异常肌肉反射是否激活ESRD患者的交感神经系统。本研究的第二部分将检查透析中运动是否改善高血压、交感神经功能亢进和交感神经系统的肌肉反射激活正常化。如果运动疗法是无效的，那么透析中运动可能成为治疗方案的主流部分，以降低ESRD患者的心血管风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with end-stage renal disease (ESRD) suffer from very high rates of cardiovascular morbidity and morality, and high blood pressure and sympathetic hyperactivity certainly contibute to the increase in cardiovascular events. The first part of this study will examine whether or not muscle deconditioning and abnormal muscle reflexes activate the sypathetic nervous system in ESRD patients. The second part of the study will then examine whether or not intradialytic exercise ameliorates hypertension, sympatheic hyperactivity, and normalizes muscle reflex activation of the sympathetic nervous system. If exercise therapy is ofund to be beneficial, then intradialytic exercise may become a mainstream part of the therapeutic regimen to decrease cardiovascular risk in patients with ESRD.