THE EFFECT OF INTRADIALYTIC EXERCISE ON SYMPATHETIC HYPERACTIVITY IN PATIENTS

透析期间运动对患者交感神经亢进的影响

• 批准号: 7716725
• 负责人: Jeanie Park
• 金额: $ 0.72万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-20 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716725
• 关键词: Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; End stage renal failure; Event; Exercise; Funding; Grant; High Blood Pressure; Hyperactive behavior; Hypertension; Institution; Mainstreaming; Morality; Morbidity - disease rate; Muscle; Nervous system structure; Patients; Physical therapy exercises; Rate; Reflex action; Research; Research Personnel; Resources; Source; Sympathetic Nervous System; Therapeutic; Treatment Protocols; United States National Institutes of Health; cardiovascular risk factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with end-stage renal disease (ESRD) suffer from very high rates of cardiovascular morbidity and morality, and high blood pressure and sympathetic hyperactivity certainly contibute to the increase in cardiovascular events. The first part of this study will examine whether or not muscle deconditioning and abnormal muscle reflexes activate the sypathetic nervous system in ESRD patients. The second part of the study will then examine whether or not intradialytic exercise ameliorates hypertension, sympatheic hyperactivity, and normalizes muscle reflex activation of the sympathetic nervous system. If exercise therapy is ofund to be beneficial, then intradialytic exercise may become a mainstream part of the therapeutic regimen to decrease cardiovascular risk in patients with ESRD.

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