THE EFFECT OF INTRADIALYTIC EXERCISE ON SYMPATHETIC HYPERACTIVITY IN PATIENTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 终末期肾病(ESRD)患者的心血管发病率和死亡率非常高，高血压和交感神经过度活跃肯定与心血管事件的增加有关。这项研究的第一部分将检验肌肉去条件化和异常肌肉反射是否激活终末期肾病患者的交感神经系统。这项研究的第二部分将检查传统透析运动是否改善高血压、交感神经过度活动，并使交感神经系统的肌肉反射激活正常化。如果运动疗法被证明是有益的，那么透析内运动可能成为降低终末期肾病患者心血管风险的治疗方案的主流部分。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with end-stage renal disease (ESRD) suffer from very high rates of cardiovascular morbidity and morality, and high blood pressure and sympathetic hyperactivity certainly contibute to the increase in cardiovascular events. The first part of this study will examine whether or not muscle deconditioning and abnormal muscle reflexes activate the sypathetic nervous system in ESRD patients. The second part of the study will then examine whether or not intradialytic exercise ameliorates hypertension, sympatheic hyperactivity, and normalizes muscle reflex activation of the sympathetic nervous system. If exercise therapy is ofund to be beneficial, then intradialytic exercise may become a mainstream part of the therapeutic regimen to decrease cardiovascular risk in patients with ESRD.