Structure-based design for neutralizing antibodies against SIV/HIV

基于结构的 SIV/HIV 中和抗体设计

• 批准号: 7508914
• 负责人: ELLIS L REINHERZ
• 金额: $ 13.33万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7508914
• 关键词: Adjuvant; Affinity; Antibodies; Antibody Formation; Antigens; Binding; Binding Sites; Biological Assay; Boston; CCR5 gene; CD4 Positive T Lymphocytes; Cavia; Cell physiology; Cells; Chimeric Proteins; Complement 3d; Complex; Crystallization; Dana-Farber Cancer Institute; Dictyostelium discoideum; Elements; Escherichia coli; Fab Immunoglobulins; Face; Fluorescence Polarization; G-substrate; Generations; HIV; HIV envelope protein; HIV-1; Helper-Inducer T-Lymphocyte; Immunity; Immunization; Immunologic Deficiency Syndromes; Immunosuppressive Agents; In Vitro; Individual; Instruction; Link; Mammals; Molecular; Names; Nature; Numbers; Pichia; Principal Investigator; Printing; Process; Production; Protein Fragment; Proteins; Research Project Grants; SIV; Site; Solubility; Specific qualifier value; Structure; Surface Plasmon Resonance; System; T-Lymphocyte; Testing; Vaccination; Vaccine Design; Virus Diseases; X-Ray Crystallography; base; design; env Gene Products; immunogenicity; in vivo; inhibitor/antagonist; neutralizing antibody; programs; protein protein interaction; response; simian human immunodeficiency virus