运动神经元对虚构运动模式生成的贡献-猫眼课题宝

运动神经元对虚构运动模式生成的贡献

批准号：

7544583

负责人：

Terrence Michael Wright

金额：

$2.74万

依托单位：

EMORY UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2008

资助国家：

美国

项目状态：

已结题

起止时间：

2008-07-01 至 2010-06-30

来源：

https://reporter.nih.gov/project-details/7544583

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DESCRIPTION (provided by applicant): The goal of the present investigation is to elucidate the contribution of motor neurons in the elaboration of rhythmic motor patterns, such as respiration or locomotion, driven by central pattern generators (CPGs). While the mechanisms of operation of CPGs have been well investigated, less is known about how motor neurons transform their input into a behaviorally relevant fictive motor pattern. It is therefore important to determine whether motor neurons are simply passive input-output systems or whether they possess properties that allow them to shape the motor pattern. Using the leech heartbeat central pattern generator as a model system, I will pursue the following specific aims: Specific Aim 1: Characterize the intrinsic membrane properties and electrical coupling of heart motor neurons. I will use standard electrophysiological techniques and dye-coupling experiments to characterize intrinsic membrane properties and quantify the strength aoupling to living motor neurons when their endogenous input is blocked and then assess the activity patterns assumed by these neurons. Specific Aim 3: Resolve the discrepancy in activity patterns assumed by our current mathematical model of CPG control of heart motor neurons and the activity pattern of motor neurons in the living system. For this aim I will modify the simplified model motor neurons of the existing model by incorporating the experimental findings of the first two aims. Together, these specific aims will contribute to our understanding of how motor neurons contribute to ongoing rhythmic motor patterns. Furthermore, the insights generated here will help establish general principles for understanding the interplay between central pattern generators and the motor neurons responsible for elaborating their output. PUBLIC HEALTH RELEVANCE The predominant result of spinal cord injury (SCI) is the loss of motor control, particularly for rhythmic behaviors such as walking. Understanding the general principles of functional motor pattern generation and in particular the role of motor neurons in shaping these patterns may prove useful in the development of rehabilitative strategies and prostheses for SCI.

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Contribution of Motor Neurons to Fictive Motor Pattern Generation

批准号：

7748014
项目类别：
资助金额：

$2.76万
财政年份：

2008
负责人：

Terrence Michael Wright
依托单位：

EMORY UNIVERSITY

国内基金

海外基金

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批准号：

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项目类别：

外国学者研究基金项目
资助金额：

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批准年份：

2024
负责人：

YU BYUNGJUN
依托单位：

上海理工大学管理学院

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批准号：

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项目类别：

外国学者研究基金项目
资助金额：

--
批准年份：

2024
负责人：

YU BYUNGJUN
依托单位：

上海理工大学管理学院