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Contraception & Metabolic Changes in HIV-positive Women

避孕

基本信息

批准号：
7408647
负责人：
Julie A Womack
金额：
$ 0.2万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-05-01 至 2008-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7408647
关键词：
Acquired Immunodeficiency Syndrome Adolescent Adverse effects Affect African American Age Age of Onset Area Cardiovascular Diseases Cause of Death Child Chronic Disease Cohort Studies Color Combined Oral Contraceptives Contraceptive Agents Contraceptive Usage Contraceptive methods Data Analyses Death Rate Diabetes Mellitus Diagnosis Epidemic Ethnic group Family Fatty acid glycerol esters Fellowship Female General Population Glucose Glucose Intolerance HIV Heart Diseases Highly Active Antiretroviral Therapy Hispanics Hormonal Hormones Hypertension Hypertriglyceridemia Individual Insulin Resistance International Life Lipids Literature Metabolic Metabolic Diseases Metabolic syndrome Minority Names National Health and Nutrition Examination Survey Nature Non-Insulin-Dependent Diabetes Mellitus Obesity Opportunistic Infections Outcome Palliative Care Population Pregnancy Pregnancy Rate Premenopause Prevalence Progestins Provider Rate Research Research Methodology Research Personnel Risk Risk Factors Sterilization for infection control Stroke Time Training United States Virus Diseases Woman Youth age group antiretroviral therapy birth control cohort design experience high density lipoprotein-1 impaired glucose tolerance lipid metabolism male men pill racial and ethnic

项目摘要

Management of the side effects of antiretroviral therapy (ART) has become a primary focus in the treatment of human immunodeficiency virus (HlV)-infected individuals. Among the most pervasive of these side effects are the metabolic complications. As more women are infected with HIV, and as HIV/AIDS becomes a chronic disease rather than a lethal diagnosis, more of these women will be looking for ways to have families and space pregnancies, rather than to terminate their ability to reproduce. However, despite research in the general literature that points to significant metabolic dysregulation with contraceptive use, especially in areas that overlap with the side effects seen in HIV and its treatment, no research has yet examined whether or not contraceptive hormone use contributes to HIV-infected women's risk for metabolic complications. A secondary data analysis of the Women's Interagency HIV Study (WIHS) cohort is proposed as an initial step towards investigating this problem. The training plan is designed to provide the informational background and research experience necessary to allow the trainee to carry out the research plan. The sponsors will contribute their expertise in HIV/AIDS, metabolic dysregulation, and research methodology.

抗逆转录病毒治疗（ART）的副作用管理已成为治疗的主要焦点人类免疫缺陷病毒（HIV）感染的个体。在这些副作用中，是代谢并发症随着越来越多的妇女感染艾滋病毒，随着艾滋病毒/艾滋病成为一种慢性疾病，疾病，而不是致命的诊断，更多的这些妇女将寻找方法有家庭，太空怀孕，而不是终止他们的繁殖能力。然而，尽管研究表明，一般文献指出，避孕药具的使用会导致显著的代谢失调，特别是在以下地区：这些副作用与艾滋病及其治疗中出现的副作用重叠，但还没有研究表明，避孕激素的使用增加了感染艾滋病毒的妇女患代谢并发症的风险。一作为第一步，建议对妇女机构间艾滋病研究（WIHS）队列进行二级数据分析来调查这个问题培训计划旨在提供信息背景和必要的研究经验，使受训者能够执行研究计划。提案国将贡献他们在艾滋病毒/艾滋病，代谢失调和研究方法方面的专业知识。