The BK current, Ic, and Fast AHP in learning & aging

学习中的 BK current、Ic 和 Fast AHP

• 批准号: 7409072
• 负责人: Elizabeth Matthews
• 金额: $ 2.8万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7409072
• 关键词: Action Potentials; Address; Adult; Age; Aging; Agonist; Animals; Blinking; Calcium; Cell Death; Cells; Cellular Membrane; Characteristics; Cyclic AMP-Dependent Protein Kinases; Disease; Elderly; Fellowship; Fire - disasters; Frequencies; Hippocampus (Brain); Hour; Immunohistochemistry; Impaired cognition; Impairment; Individual; Kinetics; Learning; Longevity; Membrane; Memory; Memory Loss; Molecular; Names; Nerve Degeneration; Neurons; Organism; Pathway interactions; Pharmacology; Phosphotransferases; Potassium; Probability; Process; Protein Phosphatase 2A Regulatory Subunit PR53; Protocols documentation; Purkinje Cells; Pyramidal Cells; Rate; Rattus; Regulation; Reporting; Signal Transduction; Time; Training; Water; Width; age group; age related; aging population; chelation; conditioning; density; experience; large-conductance calcium-activated potassium channels; mature animal; neuronal cell body; neuronal excitability; neurotoxic; normal aging; voltage; young adult

DESCRIPTION (provided by applicant): Cognitive decline and memory problems are a prominent feature of so-called "normal" aging. However, some would argue that this memory loss is not normal, and should be addressed as an early disease state. Across the adult life span, the process of learning new information and storing permanent memories becomes more and more difficult, and often fails entirely. Storing information alters the functionality of neurons through many mechanisms. One of these pathways is altering the excitability of the cell. Reduced neuronal excitability could be responsible for an inability to receive and store new information. The AHP and slow AHP currents have previously been implicated in learning and age-related learning deficits. Another faster potassium current named Ic, or fAHP is known to be both voltage and calcium dependent. Because previous reports have shown that the involvement of the AHP in learning is altered over time, it is expected that older subjects will have an altered Ic current when compared to younger adults, contributing to age-related learning deficits. This study proposes to examine the fast AHP current, Ic, and its relationship to somatic excitability after learning and alterations in this current caused by normal aging.

描述（由申请人提供）：认知衰退和记忆问题是所谓“正常”衰老的一个显着特征。然而，有些人认为这种记忆丧失是不正常的，应该作为早期疾病状态来解决。在成人的一生中，学习新信息和存储永久记忆的过程变得越来越困难，并且常常完全失败。存储信息通过多种机制改变神经元的功能。这些途径之一是改变细胞的兴奋性。神经元兴奋性降低可能导致无法接收和存储新信息。层次分析法和缓慢的层次分析法电流先前被认为与学习和与年龄相关的学习缺陷有关。另一种更快的钾电流称为 Ic 或 fAHP，已知它既依赖于电压又依赖于钙。由于之前的报告表明，AHP 在学习中的参与会随着时间的推移而改变，因此预计老年受试者与年轻人相比，Ic 电流会发生变化，从而导致与年龄相关的学习缺陷。本研究旨在检查快速 AHP 电流 Ic 及其与学习后的躯体兴奋性以及正常衰老引起的电流变化的关系。