Aging and Neural Ensembles in the Perirhinal Cortex

鼻周皮层的衰老和神经系统

• 批准号: 7342448
• 负责人: SARA N BURKE
• 金额: $ 3.43万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-09 至 2009-01-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7342448
• 关键词: Accounting; Address; Adult; Affect; Age; Age-associated memory impairment; Aging; Aging-Related Process; Animal Experiments; Animals; Area; Back; Behavior; Behavioral; Brain; Brain imaging; Brain region; Cell Aging; Cells; Cellular Compartment Analysis; Condition; Corpus striatum structure; Data; Depth; Familiarity; Fluorescent in Situ Hybridization; Goals; Hippocampal Formation; Hippocampus (Brain); Human; Image; Imaging Techniques; Impairment; Implant; Individual; Investigation; Knowledge; Learning; Lesion; Link; Longevity; Measures; Memory; Memory Loss; Memory impairment; Methods; Monkeys; Neocortex; Neurons; Pattern; Physiological; Physiology; Process; Property; Rattus; Reporting; Research Personnel; Retrieval; Role; Running; Semantic Dementias; Semantics; Signal Transduction; Sleep; Stimulus; Structure; System; Technology; Visual; age related; aged; cell age; classical conditioning; cognitive change; concept; design; experience; memory recognition; memory trace reactivation; morris water maze; nonhuman primate; normal aging; object recognition; relating to nervous system; research study; response

During the past several decades, the hippocampus has been an empirical focus of age-related memory decline. While this isjustified, the extent to which changes in the perirhinal cortex, a region extensively interconnected with the hippocampus, contribute to age-related behavioral deficits is unknown. Humans with lesions of the hippocampus lose the ability to form new memories while humans with lesions of the perirhinal cortex develop semantic dementia, a condition characterized by an insidious and gradual breakdown in semantic knowledge. Thus, while the hippocampus is criticalfor forming new memories, the perirhinal cortex may be integrally involved in providing content to those memories. Whether the response properties of perirhinal neurons change, and/or there is a decline in perirhinal plasticity during normal aging that contributes to memory impairment, is the major question addressed in the present proposal. To begin to address this, perirhinal function and the mechanisms of recognition memory will be investigated in adult and aged rats using electrophysiological recordings and imaging neural ensembles with cellular compartmental analysis of temporal activity by fluorescence in situ hybridization.

在过去的几十年里，海马体一直是与年龄相关的记忆的经验焦点