Functional Imaging of the Human FEF
人类 FEF 的功能成像
基本信息
- 批准号:7383848
- 负责人:
- 金额:$ 31.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-04-05 至 2011-03-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS Dementia ComplexAccountingAlzheimer&aposs DiseaseAnimal ModelAnimalsAreaAttentionAttention deficit hyperactivity disorderBehaviorBehavioralBiological ModelsBrainBrain regionCognitionCognitiveCoupledDataDiagnosticDiseaseFunctional ImagingFunctional Magnetic Resonance ImagingGoalsHomologous GeneHumanImageIntentionLeadLocalizedLocationMaintenanceMeasuresMemoryMental disordersMethodsMindModelingMonkeysMotivationMotorNeuronsParkinson DiseasePatternPerformancePersonal SatisfactionPhysiologyPrefrontal CortexProcessPublic HealthResearch PersonnelRestSaccadesSchizophreniaSensoryShort-Term MemorySubstance abuse problemSystemTestingTherapeutic procedureThinkingTranslatingVisual attentionWorkdesignfrontal eye fieldsimprovedindexingneuromechanismoculomotorprognosticrelating to nervous systemresearch studytheoriesvisual motor
项目摘要
The prefrontal cortex (RFC) is critical for adaptive higher-order cognitive behaviors that are compromised by
a wide variety of mental health disorders including schizophrenia, (ADHD), substance abuse disorders,
Alzheimer's and Parkinson's Disease, and AIDS-related dementia. A better understanding of basic neural
mechanisms will lead to improved diagnostic, prognostic, and therapeutic procedures. Although the RFCis
critical for the planning, maintenance, selection, and execution of willed behavior, we know very little about
the mechanisms by which it accomplishes these goals. Barriers to our progress in this regard include 1) a
poor understanding of how the crucial animal work on RFC functions translates to the human species we are
trying to understand, and 2) a lack of understanding of how the RFC influences ongoing behavior through its
functional interactions with other brain areas. Here we propose a divide-and-conquer strategy for better
understanding the functions of the RFC. In AIM 1, we will localize a key portion of the RFC, the human
homolog of the monkey frontal eye field (FEF) and treat it as a model system for detailed study of RFC
functions. We strategically chose the FEF as our model because 1) unlike other RFC areas, we have
methods for localizing it in humans, 2) data from monkey FEF, as compared to other RFC areas, offer
testable predictions about the functional homologies between the species, and most importantly 3) the FEF
is implicated in many of the same high-level cognitive behaviors that the RFC in general is implicated. We
will study the mechanisms that the human FEF uses for planning, attention, memory, and selection. Working
within a better-defined and constrained system like the oculomotor system may quickly lead to mechanistic
accounts of these functions that may be less tenable in a more complicated and less understood system like
the RFC as a whole. Although the RFC is thought to influence ongoing behavior through its functional
interactions with other brain areas, there is a dearth of evidence to support this theory. In AIM 2, we will use
fMRI to measure functional interactions between the RFC and other brain areas that together may form
networks supporting the critical behaviors. Together, the two AIMS embrace both functional specialization at
the local level and distributed processing at the network level and will allow us to test critical hypotheses
about how the RFC supports intention, attention, and working memory.
前额叶皮层(RFC)对适应性高阶认知行为至关重要,
各种各样的精神健康障碍,包括精神分裂症,(多动症),物质滥用障碍,
阿尔茨海默氏症和帕金森氏症,以及艾滋病相关的痴呆症。更好地理解基本神经
机制将导致改进的诊断、预后和治疗程序。虽然RFC
对于计划,维护,选择和执行意志行为至关重要,我们对它知之甚少
实现这些目标的机制。阻碍我们在这方面取得进展的障碍包括:
对RFC功能的关键动物工作如何转化为我们人类物种的理解不足
试图理解,2)缺乏对RFC如何通过其影响正在进行的行为的理解,
与其他大脑区域的功能性互动。在这里,我们提出了一个分而治之的战略,
了解RFC的功能。在AIM 1中,我们将本地化RFC的关键部分,即人
同源的猴子额眼场(FEF),并把它作为一个模型系统的详细研究RFC
功能协调发展的我们战略性地选择FEF作为我们的模型,因为1)与其他RFC领域不同,我们有
在人类中定位它的方法,2)来自猴子FEF的数据,与其他RFC领域相比,提供了
关于物种之间功能同源性的可测试预测,最重要的是3)FEF
与RFC一般所涉及的许多相同的高级认知行为有关。我们
将研究人类FEF用于计划,注意力,记忆和选择的机制。工作
在一个更好的定义和约束系统,如眼科系统,可能会很快导致机械
这些功能的帐户,可能是不太站得住脚的一个更复杂和更少的理解系统,如
整个RFC。尽管RFC被认为通过其功能性影响正在进行的行为,
由于与其他大脑区域的相互作用,缺乏证据支持这一理论。在AIM 2中,我们将使用
功能磁共振成像测量RFC和其他大脑区域之间的功能相互作用,
支持关键行为的网络。这两个AIMS共同包含两个功能专业化,
本地级和网络级的分布式处理,并将使我们能够测试关键假设
RFC如何支持意图、注意力和工作记忆。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CLAYTON E CURTIS其他文献
CLAYTON E CURTIS的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CLAYTON E CURTIS', 18)}}的其他基金
Deep sampling of cognitive effects in the human visual system
人类视觉系统认知效应的深度采样
- 批准号:
10658424 - 财政年份:2023
- 资助金额:
$ 31.94万 - 项目类别:
Neural synchronization of human frontoparietal cortex
人类额顶皮层的神经同步
- 批准号:
8720874 - 财政年份:2013
- 资助金额:
$ 31.94万 - 项目类别:
Neural synchronization of human frontoparietal cortex
人类额顶皮层的神经同步
- 批准号:
8542898 - 财政年份:2012
- 资助金额:
$ 31.94万 - 项目类别:
Neural synchronization of human frontoparietal cortex
人类额顶皮层的神经同步
- 批准号:
8445860 - 财政年份:2012
- 资助金额:
$ 31.94万 - 项目类别:
Essential Cortical Mechanisms for Working Memory
工作记忆的基本皮质机制
- 批准号:
10676983 - 财政年份:2006
- 资助金额:
$ 31.94万 - 项目类别:
相似海外基金
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
- 批准号:
24K16488 - 财政年份:2024
- 资助金额:
$ 31.94万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
- 批准号:
10100360 - 财政年份:2024
- 资助金额:
$ 31.94万 - 项目类别:
Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
- 批准号:
24K04974 - 财政年份:2024
- 资助金额:
$ 31.94万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
- 批准号:
2312319 - 财政年份:2023
- 资助金额:
$ 31.94万 - 项目类别:
Standard Grant
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
- 批准号:
23K01686 - 财政年份:2023
- 资助金额:
$ 31.94万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
- 批准号:
23K01692 - 财政年份:2023
- 资助金额:
$ 31.94万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
- 批准号:
23K01695 - 财政年份:2023
- 资助金额:
$ 31.94万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
- 批准号:
23K01713 - 财政年份:2023
- 资助金额:
$ 31.94万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
- 批准号:
23K01715 - 财政年份:2023
- 资助金额:
$ 31.94万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
- 批准号:
10585388 - 财政年份:2023
- 资助金额:
$ 31.94万 - 项目类别: