A Worldwide Research Network of Dynamic Cardiac Images

全球动态心脏图像研究网络

• 批准号: 7447842
• 负责人: ROBERT M JUDD
• 金额: $ 57.83万
• 依托单位: HEART IMAGING TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-20 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7447842
• 关键词: Accounting; Achievement; Address; Americas; Architecture; Asia; Cardiac; Cardiovascular system; Cataloging; Catalogs; Clinical; Collaborations; Computer software; Computers; Data; Data Analyses; Data Set; Data Sources; Distant; Effectiveness; Ensure; Equipment; Europe; Generations; Geographic Locations; Germany; Goals; Health Insurance Portability and Accountability Act; Hospitals; Human; Image; Imaging technology; Individual; Institutes; Institution; Internet; Knowledge; Laws; Libraries; Life; Link; Location; MRI Scans; Magnetic Resonance; Magnetic Resonance Imaging; Medical; Medical Imaging; Medical center; Meta-Analysis; Methods; Modality; Modeling; Monitor; Multicenter Studies; NIH Program Announcements; Names; Numbers; Operating System; Other Imaging Modalities; Patients; Phase; Positioning Attribute; Privacy; Procedures; Production; Research; Research Personnel; Resources; Secure; Site; Small Business Technology Transfer Research; Social Security Number; Standards of Weights and Measures; System; Test Result; Testing; Time; Universities; University Hospitals; Vendor; base; design; heart imaging; patient privacy; prototype; research study; response; scale up; single photon emission computed tomography; software development; tool

DESCRIPTION (provided by applicant): This is a Phase I of a fast-track STTR application submitted in response to Program Announcement PA-03-001 ("Knowledge Integration across Distributed Heterogeneous Data Sources"). We propose a collaborative effort between Heart Imaging Technologies, LLC (HeartIT) and Duke University's Cardiovascular Magnetic Resonance Center (DCMRC). The goal of the collaboration is to develop software supporting a worldwide research network of dynamic cardiac images based on existing world-wide web standards. Dr. Judd and his colleagues are recognized leaders in the field of cardiovascular MRI and have an established base of former collaborators and trainees currently located at different medical institutions across the world. Collaborative research, however, has been slowed by a lack of methods to share images and other data amongst these colleagues. In May 2000, Dr. Judd and others formed HeartIT to address these issues by developing image management systems based on converting images from DICOM format to web pages. Currently, HeartlT's third-generation commercial system (WebPAX(tm)) allows viewing of dynamic magnetic resonance images on any computer with a standard web browser (eg. Microsoft Explorer) and is in production clinical use at Duke University Hospital. Worldwide, a total of twelve similar HeartIT systems are operating at medical institutions such as Johns Hopkins Hospital, the Nashville Cardiovascular MRI Institute, and the Robert Bosch Hospital in Germany. These existing systems, as well as the close collaboration between Duke University and HeartIT, provide a unique opportunity to inexpensively and efficiently create a distributed network to share research data. In this STTR, we propose a major expansion of the existing WebPAX(tm) software which will allow these existing systems to be connected together to form a global network for sharing medical images based entirely on world-wide web standards. In the short term, this achievement will produce an important research resource supporting collaborative studies focused on the rapidly evolving field of cardiovascular MRI. In the longer term, however, the resulting global cardiovascular MRI network will serve as a fully-functional prototype for a generally-applicable computing architecture designed to provide worldwide integration of medical images acquired based on heterogeneous imaging modalities (MRI, echo, cath, SPECT) and equipment (GE, Siemens, Philips) distributed across distant geographic locations (Americas, Europe, Asia). In this application, we propose to create a "public" WebPAX user interface which allows viewing of de-identified image data from physical locations outside Duke (Aim 1), to construct an "Image Location Library" based on a secure web site with user-, group- and study-level accounts to catalog de-identified image data across multiple sites (Aim 2), and to test the resulting worldwide network of dynamic cardiac images using a real-life multicenter research study (Aim 3). Achieving these Aims will simultaneously create a powerful tool for research involving cardiovascular MRI as well as position HeartIT for an expansion to support for other imaging modalities through a Phase II SBIR/STTR.

描述（由申请人提供）：这是根据计划公告 PA-03-001（“跨分布式异构数据源的知识集成”）提交的快速 STTR 申请的第一阶段。我们建议 Heart Imaging Technologies, LLC (HeartIT) 和杜克大学心血管磁共振中心 (DCMRC) 开展合作。此次合作的目标是开发软件，支持基于现有万维网标准的全球动态心脏图像研究网络。 Judd 博士和他的同事是心血管 MRI 领域公认的领导者，并拥有一批目前分布在世界各地不同医疗机构的前合作者和实习生。然而，由于缺乏在这些同事之间共享图像和其他数据的方法，协作研究已经放缓。 2000 年 5 月，Judd 博士和其他人成立了 HeartIT，通过开发基于将图像从 DICOM 格式转换为网页的图像管理系统来解决这些问题。目前，HeartlT 的第三代商业系统 (WebPAX(tm)) 允许在任何具有标准网络浏览器（例如 Microsoft Explorer）的计算机上查看动态磁共振图像，并已在杜克大学医院投入生产临床使用。在全球范围内，约翰霍普金斯医院、纳什维尔心血管 MRI 研究所和德国罗伯特博世医院等医疗机构共有 12 个类似的 HeartIT 系统正在运行。这些现有系统以及杜克大学和 HeartIT 之间的密切合作，提供了一个独特的机会，可以廉价且高效地创建分布式网络来共享研究数据。在此 STTR 中，我们建议对现有 WebPAX(tm) 软件进行重大扩展，该软件将允许这些现有系统连接在一起，形成一个完全基于全球网络标准共享医学图像的全球网络。短期内，这一成果将产生重要的研究资源，支持重点关注快速发展的心血管 MRI 领域的合作研究。然而，从长远来看，由此产生的全球心血管 MRI 网络将作为通用计算架构的全功能原型，旨在提供基于分布在遥远地理位置（美洲、欧洲、亚洲）的异构成像模式（MRI、回波、导管、SPECT）和设备（GE、西门子、飞利浦）获取的医学图像的全球集成。在此应用中，我们建议创建一个“公共”WebPAX 用户界面，允许从杜克大学以外的物理位置查看去识别化的图像数据（目标 1），基于具有用户、组和研究级别帐户的安全网站构建“图像位置库”，以对多个站点的去识别化图像数据进行编目（目标 2），并使用真实的多中心研究测试由此产生的全球动态心脏图像网络（目标 3）。实现这些目标将同时为涉及心血管 MRI 的研究创建一个强大的工具，并通过 II 期 SBIR/STTR 进行扩展以支持其他成像模式。