Host cell death signaling and susceptibility to bacterial gut infection

宿主细胞死亡信号传导和对细菌肠道感染的易感性

• 批准号: nhmrc : GNT1144977
• 负责人: Dr Jaclyn Pearson
• 金额: $ 68.23万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/host-cell-death-gut-infection/1348654
• 关键词: Host; cell; death; signaling; susceptibility

Bacterial infections are a major cause of infectious disease worldwide. Here we aim to characterise immune responses that help fight infection by E. coli and Salmonella. These bacteria have evolved ways to shut down many of our immune responses during infection, allowing them to survive and cause disease. This work will help understand the complex relationship between gut bacteria and our immune system and provide solutions for controlling infection and treating immune disorders of the gut.

细菌感染是世界范围内传染病的主要原因。在这里，我们的目标是增强免疫反应，帮助对抗E。大肠杆菌和沙门氏菌。这些细菌已经进化出了在感染过程中关闭我们许多免疫反应的方法，使它们能够存活并引起疾病。这项工作将有助于了解肠道细菌和我们的免疫系统之间的复杂关系，并为控制感染和治疗肠道免疫疾病提供解决方案。