Optimized Conditioned Processing for Cochlear Implants

人工耳蜗的优化调节处理

• 批准号: 7336754
• 负责人: Jay T. Rubinstein
• 金额: $ 37.38万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-09 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7336754
• 关键词: Acoustic Nerve; Acoustics; Animal Model; Animals; Auditory; Auditory system; Basilar Membrane; Bilateral; Brain Stem; Categories; Clinical; Cochlear Implants; Code; Complement; Complex; Computer Simulation; Computers; Condition; Cues; Data; Electrodes; Equilibrium; Fire - disasters; Frequencies; Goals; Growth; Hearing; Human; Implant; Loudness; Maps; Methods; Nerve; Nerve Fibers; Neurons; Noise; Numbers; Patients; Pattern; Perception; Performance; Physiologic pulse; Physiological; Pilot Projects; Pitch Perception; Population; Principal Investigator; Procedures; Process; Psychophysiology; Pulse Rates; Pulse taking; Range; Rate; Research Personnel; Resolution; Shapes; Signal Transduction; Speech; Speech Discrimination; Speech Perception; Stimulus; Testing; Thinking; Time; Time Perception; Training; Work; base; computerized data processing; conditioning; ganglion cell; implantable device; improved; programs; simulation; sound; spiral ganglion

High levels of speech perception in quiet are currently available to a significant percentage of modern cdchlear implant recipients. In a noisy background, however, particularly if that noise is competing speech, speech perception is dramatically impaired. One possible method for improving speech perception in noise is to improve the temporal representation of speech in discharge patterns of electrically stimulated auditory nerve fibers. This method would also be expected to improve the performance of bilateral implant recipients on tasks requiring brainstem analysis of interaural timing. Detailed biophysical models and animal studies have demonstrated that improved temporal representation can be accomplished through the use of "conditioning stimuli" - trains of unmodulated high-rate pulses that desynchronize activity of auditory neurons to competing signals. Use of this procedure has led to dramatically increased speech perception in quiet and/or noise in some subjects, but not in others. The goal of the proposed work is to optimize the presentation of both the speech signal and the conditioner so as to maximize speech perception in quiet and noise for unilateral implant recipients, as well as improve perception of temporally-based lateralization and binaural unmasking in bilateral implantees. Because temporal pitch mechanisms demand accurate place information if they are to be useful, and pitch is thought critical for speech discrimination in competing speech, filter-to-electrode mappings will be manipulated in conditioned speech processors to maximize performance on a test of spondees in steady-state noise, "babble noise", temporally modulated noise, as well as on HINT sentences in speech-shaped noise. The results will allow optimization of conditioned processors for unilateral and bilateral cochlear implant recipients. In those bilateral implant recipients who have interaural timing perception for electrical stimuli in the physiologic range, this work has the potential to provide significant additional binaural benefits from a clinical speech processor beyond those currently available via interaural amplitude differences. In unilateral implantees, this work has already demonstrated substantial benefit in a limited number of subjects; it is our goal to deliver these benefits to the broader population of implant recipients.

目前，相当一部分现代人在安静状态下具有高水平的言语感知能力。 cdchlear 植入物接受者。然而，在嘈杂的背景下，特别是当噪音是竞争性语音时， 言语感知严重受损。一种改善噪声中语音感知的可能方法 是为了改善电刺激听觉放电模式中语音的时间表征 神经纤维。这种方法也有望提高双侧植入的性能 接受者需要进行耳间计时脑干分析的任务。详细的生物物理模型和 动物研究表明，可以通过以下方式实现改进的时间表征： 使用“调节刺激”——一系列未调制的高速脉冲，使听觉活动不同步 神经元竞争信号。使用此程序可显着提高言语感知能力 在某些科目中处于安静和/或噪音状态，但在其他科目中则不然。拟议工作的目标是优化 语音信号和调节器的呈现，以便最大限度地提高安静时的语音感知 和单侧植入接受者的噪音，以及改善基于时间的侧化的感知 以及双耳植入者的双耳揭露。因为时间音调机制需要准确 放置有用的信息，并且音调被认为对于比赛中的言语歧视至关重要 语音，滤波器到电极的映射将在条件语音处理器中进行操作，以最大化 受控器在稳态噪声、“杂音噪声”、时域调制噪声测试中的性能，如 以及语音形状噪声中的提示句子。结果将允许优化条件 适用于单侧和双侧人工耳蜗植入者的处理器。在那些双侧植入接受者中 对生理范围内的电刺激具有耳间定时感知，这项工作有潜力 临床语音处理器提供了超出目前的显着额外双耳益处 通过耳间振幅差异可以获得。在单侧植入者中，这项工作已经证明 在有限数量的科目中获得实质性益处；我们的目标是将这些好处带给更广泛的人 植入物接受者的人口。