Spectro-temporal and binaural response properties

频谱-时间和双耳响应特性

• 批准号: 7414481
• 负责人: MONTY A ESCABI
• 金额: $ 24.24万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7414481
• 关键词: Accounting; Acoustics; Anatomy; Area; Auditory; Auditory area; Brain Stem; Cell Nucleus; Characteristics; Class; Classification; Classification Scheme; Complex; Computer information processing; Contralateral; Dependency; Depth; Electrodes; Epithelial; Exhibits; Facility Construction Funding Category; Figs - dietary; Frequencies; Goals; Inferior Colliculus; Inherited; Lateral; Maps; Measurement; Measures; Medial; Medial geniculate body; Methods; Midbrain structure; Neurons; Noise; Pattern; Peripheral; Play; Population; Positioning Attribute; Property; Reading; Resolution; Role; Sensory; Shapes; Site; Source; Stimulus; Structure; Synapses; Techniques; Thalamic structure; Yin; auditory pathway; auditory stimulus; base; dorsal cochlear nucleus; preference; pressure; receptive field; research study; response; sound; superior olivary nucleus; three dimensional structure

DESCRIPTION (provided by applicant): The central nucleus of the inferior colliculus (ICC) plays a key role in the acoustic analysis of spectral, temporal and binaural information. Its laminar organization and highly ordered mosaic of converging afferents suggests a critical role in consolidating this acoustic information in the transition to the auditory thalamus. We hypothesize that the distributed layout of spectro-temporal and binaural receptive field features will be systematically ordered in the central nucleus in a manner that reflects the patterns of innervating afferents and the local collicular circuitry. In this study, we propose to characterize the distributed organization of spectro-temporal receptive field (STRF) preferences within the central nucleus. STRF analysis with structured broadband noise will be used to characterize neuronal preferences and to systematically relate these to measurements from conventional pure-tone stimuli. Single unit recording experiments are proposed to characterize the micro-organization of STRF preferences and to identify the roles of receptive field inheritance / construction in the transformation from the brainstem to the central nucleus. Distributed mapping of the ICC will then allow us to simultaneously characterize the global-organization of spectral, temporal and binaural receptive field preferences within the three dimensional structure. Concurrent anatomic studies will show the topographic position of two parallel recording tracks and their respective projections to medial geniculate body. The expected findings will provide a framework for understanding the acoustic analysis of spectro-temporal and binaural features in complex auditory stimuli, which we can then relate to the organizational hierarchy of brainstem inputs, local circuitry, and modular organization.

描述（由申请人提供）：下丘中央核（ICC）在频谱、时间和双耳信息的声学分析中起关键作用。它的层状组织和高度有序的会聚传入马赛克表明，它在巩固这些声学信息向听觉丘脑过渡的过程中发挥着关键作用。我们假设，频谱时间和双耳感受野功能的分布布局将系统地在中央核的方式，反映了支配传入和局部丘电路的模式。在这项研究中，我们提出了中央核团内的光谱-时间感受野（STRF）偏好的分布组织的特征。结构化宽带噪声的STRF分析将被用来表征神经元的偏好，并系统地将这些与传统的纯音刺激测量。提出单单位记录实验来表征STRF偏好的微观组织，并确定感受野遗传/构建在从脑干到中央核团的转化中的作用。ICC的分布式映射将使我们能够同时表征三维结构中频谱、时间和双耳感受野偏好的全球组织。同步解剖学研究将显示两个平行记录轨道的地形位置和它们各自的投影到内侧膝状体。预期的发现将为理解复杂听觉刺激中的谱时和双耳特征的声学分析提供一个框架，然后我们可以将其与脑干输入、局部电路和模块化组织的组织层次结构联系起来。

项目成果

Neural modulation tuning characteristics scale to efficiently encode natural sound statistics.

• DOI: 10.1523/jneurosci.0966-10.2010
• 发表时间: 2010-11-24
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Rodríguez FA;Chen C;Read HL;Escabí MA
• 通讯作者: Escabí MA

Precise feature based time scales and frequency decorrelation lead to a sparse auditory code.

• DOI: 10.1523/jneurosci.6506-11.2012
• 发表时间: 2012-06-20
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Chen C;Read HL;Escabí MA
• 通讯作者: Escabí MA

Distinct roles for onset and sustained activity in the neuronal code for temporal periodicity and acoustic envelope shape.

• DOI: 10.1523/jneurosci.2882-08.2008
• 发表时间: 2008-12-24
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Zheng, Yi;Escabi, Monty A.
• 通讯作者: Escabi, Monty A.

Proportional spike-timing precision and firing reliability underlie efficient temporal processing of periodicity and envelope shape cues.

比例尖峰定时精度和发射可靠性是周期性和包络形状线索的有效时间处理的基础。

• DOI: 10.1152/jn.01080.2010
• 发表时间: 2013
• 期刊: Journal of neurophysiology
• 影响因子: 2.5
• 作者: Zheng,Y;Escabí,MA
• 通讯作者: Escabí,MA