Host-microbiome interactions: mechanistic understanding for translation benefit

宿主-微生物组相互作用：翻译益处的机制理解

• 批准号: nhmrc : GNT1155179
• 负责人: A/Pr Geraint Rogers
• 金额: $ 64.92万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/host-microbiome-interactions-translation-benefit/1349182
• 关键词: Host; microbiome; interactions; mechanistic; understanding

The communities of microbes that colonise the human body (the microbiome) profoundly influence the risk of disease and response to therapy. The disruption of these systems, for example, through poor diet or antimicrobial exposure, is implicated in persistent immune dysfunction and diverse pathologies. By understanding these relationships and the mechanisms on which they are based, my aim is to inform clinical decisions, and allow the development of targeted interventions.

在人体内定居的微生物群落(微生物群)对疾病风险和治疗反应产生了深远的影响。这些系统的破坏，例如，由于不良的饮食或抗菌药物的暴露，与持续性免疫功能障碍和各种病理有关。通过了解这些关系和它们所基于的机制，我的目的是为临床决策提供信息，并允许开发有针对性的干预措施。