Continued Development for The Image-guided Surgical Toolkit Project (IGSTK)

描述(由申请人提供)：本提案将继续开发、维护、测试和评估图像引导外科工具包(IGSTK)。IGSTK是一个开源软件项目，它提供了开发图像引导系统的基本组件。该软件的初始版本于2006年2月在圣地亚哥举行的SPIE医学成像会议上向公众发布，我们继续从用户社区收到积极的反馈。该软件目前可在IGSTK网站上根据BSD开放源码许可证供任何感兴趣的各方免费下载。该软件是在过去两年的第二阶段科学技术转让赠款下开发的，该赠款将于2006年8月到期。该项目的最终目标是提供一个强大的、开源的工具包，用于快速开发用于研究和临床应用的图像引导软件。为了实现这一目标，我们需要继续开发工具包并支持用户社区。因此，我们提交这份R01提案是对PAR-05-057公告“软件的持续开发和维护”的回应。该提案的目标是用户支持、软件扩展，以及FDA批准的图像引导应用程序的开发和初步临床试验。这是一个为期三年的项目，有四个具体目标：1.通过回复电子邮件请求、修复错误、开发文档、并在SPIE医学成像会议上召开年度用户会议2.通过开发：a.多线程，更好地处理多个设备和繁重的处理负载，以及进程间通信，简化IGSTK与其他软件包的安全集成；b.验证工具包所基于的状态机模型的验证工具；3.开发应用程序模板和编程指南，使新用户更容易使用工具包开发应用程序4.开发包含针尖电磁跟踪的图像引导应用程序，并争取FDA/IRB批准进行10名患者的试点试验该项目的完成将提供一个开源软件系统，使研究人员能够快速开发图像引导应用程序，最终使患者护理受益。

DESCRIPTION (provided by applicant): This proposal is to continue to develop, maintain, test, and evaluate the Image-Guided Surgical Toolkit (IGSTK). IGSTK is an open source software project that provides the basic components to develop an image-guided system. The initial version of the software was released to the public in February 2006 at the SPIE Medical Imaging Conference in San Diego and we continue to receive positive feedback from the user community. The software is currently available on the IGSTK web site for free download by any interested party under the BSD open source license. The software was developed under a Phase II STTR grant over the last two years, which will expire in August 2006. The ultimate goal of this project is to provide a robust, open source toolkit for rapidly developing image- guided software for research and clinical applications. To realize this goal, we need to continue to develop the toolkit and support the user community. Therefore, we are submitting this R01 proposal in response to the PAR-05-057 announcement "Continued Development and Maintenance of Software". The proposal is targeted at user support, software extensions, and the development of an FDA approved image-guided application and initial clinical trial. This is a three year project with four specific aims: 1. Support the IGSTK user community by responding to email requests, fixing bugs, developing documentation, and holding an annual users meeting at the SPIE Medical Imaging conference 2. Extend the existing software by developing: a. Multi-threading for better handling of multiple devices and heavy processing loads along with inter-process communication to simplify safe integration of IGSTK with other software packages b. Validation tools for the state machine model that the toolkit is based on 3. Develop an application template and programming guide to make it easier for new users to develop applications using the toolkit 4. Develop an image-guided application for lung biopsy incorporating electromagnetic tracking of the needle tip and pursue FDA/IRB approval for a pilot trial of 10 patients The completion of this project will provide an open source software system that will allow researchers to rapidly develop image-guided applications that will ultimately benefit patient care.