Continued Development for The Image-guided Surgical Toolkit Project (IGSTK)

描述（由申请人提供）：本提案旨在继续开发、维护、测试和评估图像引导外科工具包（IGSTK）。IGSTK是一个开源软件项目，它提供了开发图像引导系统的基本组件。该软件的初始版本于2006年2月在圣地亚哥举行的SPIE医学成像会议上向公众发布，我们继续收到来自用户社区的积极反馈。该软件目前可以在IGSTK网站上免费下载，任何有兴趣的人都可以在BSD开源许可下免费下载。该软件是在过去两年的第二阶段str拨款下开发的，该拨款将于2006年8月到期。这个项目的最终目标是为研究和临床应用快速开发图像引导软件提供一个健壮的、开源的工具包。为了实现这一目标，我们需要继续开发工具包并支持用户社区。因此，我们提交此R01提案以响应PAR-05-057公告“软件的持续开发和维护”。该提案的目标是用户支持，软件扩展，以及FDA批准的图像引导应用和初步临床试验的开发。这是一个为期三年的项目，有四个具体目标：1。通过响应电子邮件请求、修复错误、开发文档和在SPIE医学成像会议上举行年度用户会议来支持IGSTK用户社区2。通过开发扩展现有软件：a.多线程，以便更好地处理多个设备和繁重的处理负载，以及进程间通信，以简化IGSTK与其他软件包的安全集成b.用于工具包所基于的状态机模型的验证工具3。开发应用程序模板和编程指南，使新用户更容易使用工具包开发应用程序4。开发一种结合针尖电磁跟踪的肺活检图像引导应用程序，并寻求FDA/IRB对10名患者的试点试验的批准。该项目的完成将提供一个开源软件系统，使研究人员能够快速开发图像引导应用程序，最终使患者护理受益。

DESCRIPTION (provided by applicant): This proposal is to continue to develop, maintain, test, and evaluate the Image-Guided Surgical Toolkit (IGSTK). IGSTK is an open source software project that provides the basic components to develop an image-guided system. The initial version of the software was released to the public in February 2006 at the SPIE Medical Imaging Conference in San Diego and we continue to receive positive feedback from the user community. The software is currently available on the IGSTK web site for free download by any interested party under the BSD open source license. The software was developed under a Phase II STTR grant over the last two years, which will expire in August 2006. The ultimate goal of this project is to provide a robust, open source toolkit for rapidly developing image- guided software for research and clinical applications. To realize this goal, we need to continue to develop the toolkit and support the user community. Therefore, we are submitting this R01 proposal in response to the PAR-05-057 announcement "Continued Development and Maintenance of Software". The proposal is targeted at user support, software extensions, and the development of an FDA approved image-guided application and initial clinical trial. This is a three year project with four specific aims: 1. Support the IGSTK user community by responding to email requests, fixing bugs, developing documentation, and holding an annual users meeting at the SPIE Medical Imaging conference 2. Extend the existing software by developing: a. Multi-threading for better handling of multiple devices and heavy processing loads along with inter-process communication to simplify safe integration of IGSTK with other software packages b. Validation tools for the state machine model that the toolkit is based on 3. Develop an application template and programming guide to make it easier for new users to develop applications using the toolkit 4. Develop an image-guided application for lung biopsy incorporating electromagnetic tracking of the needle tip and pursue FDA/IRB approval for a pilot trial of 10 patients The completion of this project will provide an open source software system that will allow researchers to rapidly develop image-guided applications that will ultimately benefit patient care.