Pneumatic Drill and Robot for MRI-Guided Pediatrics Long Bone Biopsy

用于 MRI 引导儿科长骨活检的气动钻和机器人

基本信息

  • 批准号:
    10689655
  • 负责人:
  • 金额:
    $ 51.4万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-03-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

ABSTRACT The overall goal of this proposal is to complete a Phase I clinical trial of bone biopsy in pediatric patients using the novel MRI safe robot developed in our previous work. This robot will facilitate accurate MRI-guided bone biopsy and enable a new clinical workflow to reduce time to sampling and evaluation of tissue obtained from suspicious bone lesions. Our team has been developing small footprint MRI compatible robots to enable precision needle placement without radiation exposure to the patient or physician. In previous work, we designed, built, and evaluated a novel MRI safe needle guidance robot to provide accurate targeting of lesions in the long bones of the leg. The robot is actuated by unique pneumatic stepper motors and is entirely metal and electricity free, which allows it to work in the MRI environment completely free of artifacts. Targets were successfully reached using a long bone mockup in our 1.5T Siemens Aera MRI with an average 3D error of 1.39 mm and maximum error of 1.89 mm. We then completed a leg cadaver study in the tibia and femur. The cadaver study showed the need to develop an MRI-safe drill, which will be the focus of Specific Aim 1. We will follow these technical developments with additional cadaver studies in Specific Aim 2, followed by regulatory approvals and a clinical safety and feasibility trial in 20 pediatric patients in Specific Aim 3.Our specific aims are to: 1. Develop essential new components for our MRI-safe robot, specifically a new pneumatic power MRI safe bone biopsy drill and a support/fixation mechanism for securing the leg to the MRI table. 2. Complete additional cadaver studies to test the robot, drill, and mounting mechanism and confirm the proposed clinical workflow and the accuracy of the integrated system. 3. Obtain regulatory approvals for the Phase I clinical trial including FDA and IRB approval, followed by a safety and feasibility clinical trial of bone biopsy on 20 pediatric subjects using the MRI-safe robot and drill.
摘要

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Kevin R. Cleary其他文献

Kevin R. Cleary的其他文献

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{{ truncateString('Kevin R. Cleary', 18)}}的其他基金

Pneumatic Drill and Robot for MRI-Guided Pediatrics Long Bone Biopsy
用于 MRI 引导儿科长骨活检的气动钻和机器人
  • 批准号:
    10348193
  • 财政年份:
    2020
  • 资助金额:
    $ 51.4万
  • 项目类别:
MRI Compatible Robot for Improved Pain Injections in Adults and Children
MRI 兼容机器人可改善成人和儿童的疼痛注射
  • 批准号:
    9906929
  • 财政年份:
    2018
  • 资助金额:
    $ 51.4万
  • 项目类别:
An Integrated Coil and Body-Mounted MR Robot for Pediatric Arthrography
用于小儿关节造影的集成线圈和身体安装 MR 机器人
  • 批准号:
    9253391
  • 财政年份:
    2016
  • 资助金额:
    $ 51.4万
  • 项目类别:
An Integrated Coil and Body-Mounted MR Robot for Pediatric Arthrography
用于小儿关节造影的集成线圈和身体安装 MR 机器人
  • 批准号:
    9110635
  • 财政年份:
    2016
  • 资助金额:
    $ 51.4万
  • 项目类别:
MRI Compatible Body-Mounted Robot to Streamline Pediatric Shoulder Arthrography
MRI 兼容的体载机器人可简化儿科肩关节造影术
  • 批准号:
    9353413
  • 财政年份:
    2016
  • 资助金额:
    $ 51.4万
  • 项目类别:
Development/Evaluation of a User Interface for Robotically-Assisted Ureteroscopy
机器人辅助输尿管镜用户界面的开发/评估
  • 批准号:
    8892345
  • 财政年份:
    2015
  • 资助金额:
    $ 51.4万
  • 项目类别:
Pneumatic Robot for MRI-Guided Pediatrics Long Bone Biopsy
用于 MRI 引导儿科长骨活检的气动机器人
  • 批准号:
    8930925
  • 财政年份:
    2013
  • 资助金额:
    $ 51.4万
  • 项目类别:
Pneumatic Robot for MRI-Guided Pediatrics Long Bone Biopsy
用于 MRI 引导儿科长骨活检的气动机器人
  • 批准号:
    8725608
  • 财政年份:
    2013
  • 资助金额:
    $ 51.4万
  • 项目类别:
Pneumatic Robot for MRI-Guided Pediatrics Long Bone Biopsy
用于 MRI 引导儿科长骨活检的气动机器人
  • 批准号:
    8577657
  • 财政年份:
    2013
  • 资助金额:
    $ 51.4万
  • 项目类别:
Improving liver lesion biopsy in the CT suite through fusion with PET images
通过与 PET 图像融合改进 CT 套件中的肝脏病变活检
  • 批准号:
    8390856
  • 财政年份:
    2012
  • 资助金额:
    $ 51.4万
  • 项目类别:

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