Development of Arterial Spin Labeling for Clinical Applications

临床应用动脉旋转标记的开发

• 批准号: 7454410
• 负责人: ERIC C WONG
• 金额: $ 34.6万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7454410
• 关键词: Accounting; Address; Area; Arteries; Beds; Blood; Blood Vessels; Brain; Carotid Stenosis; Cataloging; Catalogs; Cause of Death; Cerebrovascular Disorders; Cerebrum; Clinical; Condition; Core-Binding Factor; Dependence; Detection; Development; Diagnosis; Diagnostic; Disease; Evaluation; Goals; Half-Life; Image; Imaging Techniques; Injection of therapeutic agent; Label; Laboratories; Location; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methodology; Methods; Monitor; Morphologic artifacts; Motion; Noise; Pathology; Pathology, Other; Patients; Perfusion; Phase; Physiologic pulse; Pulse taking; Radiation; Range; Reading; Research Personnel; Risk Assessment; Scanning; Scheme; Signal Transduction; Site; Source; Spin Labels; Stroke; Techniques; Testing; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Vascular blood supply; Work; base; cerebrovascular; clinical application; density; interest; radiofrequency; tag term; tool; tumor vascular supply

DESCRIPTION (provided by applicant): Stroke is a devastating disease that is caused by a lack of perfusion to the brain, and is the third leading cause of death in the US. Arterial spin labeling (ASL) is an MRI based method for noninvasive imaging of perfusion, using no radiation and no injections, and holds tremendous potential for aiding in the diagnosis and management of stroke. The overall objective of this project is to develop two new ASL methods for the evaluation of cerebrovascular diseases, with stroke as the primary focus. The first is Velocity Selective ASL (VSASL), which addresses the inability of conventional ASL techniques to measure cerebral perfusion in the presence of collateral and/or slow flow, a condition that is often present in stroke patients. In conventional ASL, radiofrequency pulses magnetically tag arterial blood in major arteries leading to the brain. Under conditions of slow or collateral flow, the tag, which decays away with a half life of approximately one second, can dissipate before it can be delivered to the target tissue, and can give a false reading of no perfusion. In VSASL, arterial blood is tagged based purely on flow velocity, rather than location, allowing for tagging in all locations simultaneously. VSASL is currently the only ASL technique that can in principle give accurate measures of perfusion under these conditions. Our specific aims related to bringing VSASL into clinical practice are: 1) Development of a robust 3D image acquisition method for VSASL; 2) Development of a direction independent VSASL tagging method; and 3) Optimization of VSASL for the detection of slow flow. The result of this work will be a robust ASL method for quantitative perfusion imaging in stroke. The second method is Vascular Source Imaging (VSI), which allows for the identification of the vascular source that supplies blood to the tissue of interest. VSI is a new technique with a broad range of potential clinical applications including the evaluation of carotid stenosis, risk assessment for stroke, and the identification of tumor blood supplies. VSI is early in it's development, and our aims in this area are to address two basic technical issues: 1) Optimize VSI tagging parameters based on pseudo-continuous labeling; and 2) Develop efficient VSI encoding schemes to maximize the SNR of the VSI measurement and allow for simultaneous encoding of multiple arteries. The result of this work will be robust methods for measuring not only the amount of perfusion, but also the vascular source from which that perfusion was derived.

描述（由申请人提供）：中风是一种由大脑缺乏灌注引起的毁灭性疾病，是美国第三大死亡原因。动脉自旋标记（ASL）是一种基于MRI的无创灌注成像方法，无需放射和注射，在帮助中风的诊断和治疗方面具有巨大的潜力。该项目的总体目标是开发两种新的ASL方法来评估脑血管疾病，以卒中为主要重点。第一种是速度选择性ASL (VSASL)，它解决了传统ASL技术无法测量侧支和/或慢血流时的脑灌注，这是中风患者经常出现的一种情况。在传统的ASL中，射频脉冲对通向大脑的大动脉中的动脉血液进行磁性标记。在缓慢或侧流的条件下，标签的半衰期大约为一秒，在它被递送到目标组织之前就会消散，并且会给出没有灌注的错误读数。在VSASL中，动脉血液的标记完全基于血流速度，而不是位置，允许同时在所有位置进行标记。VSASL是目前唯一原则上可以在这些条件下精确测量灌注的ASL技术。我们将VSASL引入临床实践的具体目标是：1)开发一种强大的VSASL三维图像采集方法；2)开发方向无关的VSASL标注方法；3)针对慢流检测的VSASL优化。这项工作的结果将是一个强大的ASL方法定量灌注成像脑卒中。第二种方法是血管源成像（VSI），它允许识别为感兴趣的组织提供血液的血管源。VSI是一项具有广泛临床应用潜力的新技术，包括颈动脉狭窄的评估、卒中风险评估和肿瘤血供的识别。VSI还处于早期发展阶段，我们在这一领域的目标是解决两个基本的技术问题：1)基于伪连续标记的VSI标记参数优化；2)开发有效的VSI编码方案，以最大限度地提高VSI测量的信噪比，并允许同时编码多个动脉。这项工作的结果不仅是测量灌注量的可靠方法，而且是测量灌注来源的血管的可靠方法。