Host resistance and protection against oral candidasis

宿主对口腔念珠菌病的抵抗力和保护

• 批准号: nhmrc : 143067
• 负责人: A/Pr Robert Ashman
• 金额: $ 13.1万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/host-resistance-protection-oral-candidasis/76110
• 关键词: Host; resistance; protection; against; oral

Candida albicans is an important opportunistic pathogen, that is widely represented in general medical and dental practice, as well as in the hospital environment. Clinical observations indicate that defects in innate immunity predispose patients to disseminated infection, whereas a weakened cell-mediated immune response is commonly associated with chronic oral infections. Animal models of both chronic and acute oral candidiasis have been developed and characterised by the applicants, and these have clearly implicated T cells in the process of recovery from primary infection. The models will now be used to analyse the effector mechanisms that lead to clearance of the yeast from the oral cavity, with a particular focus on the role of phagocytic cells, and their interaction with T cells. The acute model will be used to identify immunological variables that can act as markers of protection, and the effectiveness of therapeutic manipulations will be evaluated in the chronic model, with the ultimate aim of developing a protective vaccine for human infections.

白色念珠菌是一种重要的条件致病菌，广泛存在于一般医疗和牙科实践以及医院环境中。临床观察表明，先天免疫缺陷使患者易患播散性感染，而细胞介导的免疫应答减弱通常与慢性口腔感染有关。申请人已经开发和表征了慢性和急性口腔念珠菌病的动物模型，并且这些动物模型已经清楚地表明T细胞参与了从原发感染中恢复的过程。这些模型现在将用于分析导致酵母从口腔中清除的效应机制，特别关注吞噬细胞的作用及其与T细胞的相互作用。急性模型将用于确定可作为保护标志物的免疫学变量，治疗操作的有效性将在慢性模型中进行评估，最终目的是开发用于人类感染的保护性疫苗。