Genomic characterisation of novel inflammatory regulators in a mouse model of disseminated Candidiasis

播散性念珠菌病小鼠模型中新型炎症调节因子的基因组特征

• 批准号: nhmrc : 597452
• 负责人: A/Pr Robert Ashman
• 金额: $ 38.77万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genomic-characterisation-novel-disseminated-candidiasis/76193
• 关键词: Genomic; characterisation; novel; inflammatory; regulators

Genome biology offers great promise for the study of immune function, but new approaches are needed to build insights between data and disease. This project looks at the gene products used by mice susceptible to yeast infection and asks if the information is used differently in resistant animals. Blood-borne fungal infections are increasing in hospitals; we want to discover new immune gene products and understand how they contribute, so we can better predict the outcome of an infection.

基因组生物学为免疫功能的研究提供了巨大的希望，但需要新的方法来建立数据和疾病之间的见解。该项目着眼于易受酵母菌感染的小鼠所使用的基因产物，并询问这些信息是否在抗性动物中有不同的使用。医院中的血源性真菌感染正在增加;我们希望发现新的免疫基因产物，并了解它们是如何起作用的，这样我们就可以更好地预测感染的结果。