Alkynes as Masked Ylides. A Concept for New Reactions and Reactivity

炔烃作为掩蔽叶利德。

• 批准号: EP/E032168/1
• 负责人: Paul Davies
• 金额: $ 26.43万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE032168%2F1
• 关键词: Alkynes; Masked; Ylides.; Concept; New

Ylides are very useful reagents with a diverse range of reactivity, employed in the synthesis of small and large, simple and complex molecules. However, as ylides are sensitive species they can be introduced into a molecule only immediately prior to their use. Their synthetic precursors are also highly reactive species which cannot be carried through other manipulations.So whilst the ylide reactions themselves can be very effective, the long, inefficient, inflexible and intolerant strategies required to introduce them into a molecule, reduces their potential applicability. Similarly, the economy and efficiency of any synthesis that employs them is adversely affected.In this proposed research, a novel catalytic process will allow ylides to be prepared in situ, from robust functionality which can be carried through a variety of transformations unscathed. The flexible strategy to access a range of different ylides, coupled with their subsequent reactions will lead to a diverse array of new transformations. This new approach will result in more economical synthesis by utilising the power of ylide chemistry, whilst bypassing lengthy and inefficent starting material preparations. The resulting synthetic strategies will be shorter and more efficient than at present, with less chemical and time resource consumed and less waste produced.

叶立德是非常有用的试剂，具有不同范围的反应性，用于合成小的和大的，简单的和复杂的分子。然而，由于叶立德是敏感的物种，它们只能在即将使用之前引入分子中。它们的合成前体也是高活性物种，不能通过其他操作进行。因此，虽然叶立德反应本身可能非常有效，但将它们引入分子所需的漫长、低效、不灵活和不耐受的策略降低了它们的潜在适用性。同样，任何使用它们的合成的经济性和效率都受到不利影响。在这项拟议的研究中，一种新的催化方法将允许叶立德原位制备，从强大的功能，可以通过各种变换毫发无损地进行。灵活的策略，以获得一系列不同的叶立德，再加上他们随后的反应将导致各种各样的新的转变。这种新的方法将导致更经济的合成，利用叶立德化学的力量，同时绕过冗长和低效的原料制备。由此产生的合成策略将比目前更短，更有效，消耗更少的化学和时间资源，产生更少的废物。

项目成果

Alkynes as "masked" ylides under noble-metal catalysis

• DOI: 10.1351/pac-con-09-10-18
• 发表时间: 2010-07-01
• 期刊: PURE AND APPLIED CHEMISTRY
• 影响因子: 1.8
• 作者: Davies, Paul W.