Alkynes as Masked Ylides. A Concept for New Reactions and Reactivity

酰基化合物是一种非常有用的试剂，具有多种反应活性，可用于合成大小分子、简单分子和复杂分子。然而，由于酰化物是敏感物质，它们只能在使用之前立即被引入到分子中。它们的合成前体也是高度反应的物种，不能通过其他操作进行。因此，虽然乙基化反应本身可能非常有效，但将它们引入分子所需的长时间、低效率、不灵活和不耐受的策略，降低了它们的潜在适用性。同样，使用它们的任何合成的经济性和效率都会受到不利影响。在这项拟议的研究中，一种新的催化过程将允许在原位制备酰基化合物，从强大的功能，可以通过各种转化而毫发无损地进行。灵活的策略来访问一系列不同的周期，再加上它们随后的反应将导致各种各样的新转变。这种新方法将通过利用ylide化学的力量来实现更经济的合成，同时绕过冗长和低效的起始材料制备。由此产生的合成战略将比目前更短、更有效，消耗的化学和时间资源更少，产生的废物也更少。

Ylides are very useful reagents with a diverse range of reactivity, employed in the synthesis of small and large, simple and complex molecules. However, as ylides are sensitive species they can be introduced into a molecule only immediately prior to their use. Their synthetic precursors are also highly reactive species which cannot be carried through other manipulations.So whilst the ylide reactions themselves can be very effective, the long, inefficient, inflexible and intolerant strategies required to introduce them into a molecule, reduces their potential applicability. Similarly, the economy and efficiency of any synthesis that employs them is adversely affected.In this proposed research, a novel catalytic process will allow ylides to be prepared in situ, from robust functionality which can be carried through a variety of transformations unscathed. The flexible strategy to access a range of different ylides, coupled with their subsequent reactions will lead to a diverse array of new transformations. This new approach will result in more economical synthesis by utilising the power of ylide chemistry, whilst bypassing lengthy and inefficent starting material preparations. The resulting synthetic strategies will be shorter and more efficient than at present, with less chemical and time resource consumed and less waste produced.