Comprehensive Tool Development for the National Covid-19 Effort

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We are developing a comprehensive range of key reagents to aid the National and International effort against Covid-19. Covid-19 is the biggest challenge society has faced in living memory. The virus has infected many millions of people and killed over a million worldwide. In the UK, the infection rate has been among the highest in the world.The cause of Covid-19 is the virus SARS-CoV-2 virus which belongs to a poorly understood class of coronaviruses. There is currently no approved drug nor vaccine for managing Covid-19 disease. Uncertainty on the efficacy of a vaccine makes parallel efforts into both drug and vaccine development of paramount importance for disease management. To achieve this, more understanding on viral pathogenesis is necessary, only achievable with advanced collections of reagents to act as research tools and biomarkers.In consultation with the CVR in Glasgow, we responded early to the global threat posed by Covid-19 and started to design and produce all the key biological reagents necessary to enable to the national effort against SAR-CoV-2. While we did not have funding in place to enable this, we felt strongly that we needed to use our expertise and resources to ensure that researchers across the country had access to the key tools needed. We have produced a range of DNA constructs to allow researchers to express the proteins that make up the virus and to study the virus in living systems. We have also produced the 28 proteins themselves that make up the uptake virus as well as some related ones from similar diseases (SARS and MERS). We have also made a range of antibodies against all 28 parts of the virus to help researchers in a range of different procedures. We have quality checked and made available all the reagents to the wider research community via our websitehttps://mrcppu-covid.bio. We will apply a cost recovery to recoup some of the reagent costs of supply but need a contribution in order to finish our work and support the scientists who have worked over local down to make this project happen.