Physical Activity Dependent Plasticity CNS Sympathetic Nervous System Regulation

描述（由申请人提供）：久坐不动的生活方式是心血管疾病的主要危险因素，心血管疾病是美国的主要死亡原因。与缺乏身体活动有关的心血管疾病与交感神经系统的过度活跃有关。申请人的长期目标是了解久坐不动的生活方式导致心血管疾病发病率增加的机制。当前提案的目的是检验以下假设：身体不活动与身体活动在脑干中对血压调节至关重要的特定神经元群体的结构和功能中产生差异性改变。为了实现这一建议的目标，PI在密苏里州大学和澳大利亚弗林德斯研究所组建了一个专家小组。我们期望在这两年的项目结束时，确定身体活动和不活动调节延髓头端腹外侧区脊髓投射神经元的结构和功能的程度。强有力的初步数据和先前发表的数据支持这些挑衅性和独特的假设。该提案的结果将使人们更好地了解久坐不动的生活方式对心血管健康的不利影响，并确定治疗和预防心血管疾病的潜在治疗目标。

DESCRIPTION (provided by applicant): A sedentary lifestyle is a major risk factor for cardiovascular disease, the leading cause of death in the United States. Cardiovascular diseases related to physical inactivity are associated with overactivity of the sympathetic nervous system. The long term goal of the applicant is to understand the mechanisms by which a sedentary lifestyle contributes to the increased incidence of cardiovascular disease. The objective of the current proposal is to test the hypothesis that physical inactivity versus physical activity produces differential alterations in the structure and function of a specific population of neurons in the brainstem that are critical for blood pressure regulation. In order to achieve the objectives of this proposal, the PI has assembled an expert team at the University of Missouri and the Flinders Institute in Australia. We expect to establish at the end of this two year project the extent to which physical activity and inactivity regulates the structure and function of spinally projecting neurons in the rostral ventrolateral medulla. Strong preliminary data and previously published data support these provocative and unique hypotheses. The results of this proposal will provide a greater understanding of the detrimental effects of a sedentary lifestyle on cardiovascular health and define potential therapeutic targets for the treatment and prevention of cardiovascular diseases.