ChELSI: Chemical Engineering Life Science Interface

ChELSI：化学工程生命科学接口

• 批准号: EP/E036252/1
• 负责人: Geof Tomlinson
• 金额: $ 457.19万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE036252%2F1
• 关键词: ChELSI; Chemical; Engineering; Life; Science

In the United States and countries such as Singapore and Korea, chemical engineers collaborate extensively with biologists at what is termed the Life Science Interface. In the United Kingdom, such collaborations are worryingly few in numbers. We propose to establish a research centre - ChELSI, where Chemical Engineers will work at the Life Science Interface. ChELSI's purpose is to build a centre of excellence in its own right and to reach out to the whole UK chemical engineering community.ChELSI will be based in the Department of Chemical and Process Engineering at the University of Sheffield. At the core of ChELSI will be existing staff from the Biological and Environmental Systems Group bolstered by new appointments - 3 lecturers, 3 PDRAs, 3 PhD students, 2 technicians and administrative support. The University of Sheffield will contribute to ChELSI by providing 1000 m2 of new laboratories, offices and an ideas space . In this bid we seek funds to support the 11 research staff for five years and to provide laboratory equipment and consumables and small amounts of funding to enable pump-priming of external collaborations.Our vision for ChELSI is that it will be focused on problems of relevance to human health. We propose initial projects in the areas of stem cells and regenerative medicine, kidney diseases, reproductive biology and protein aggregation. However the staff resources we propose should be much more broadly oriented and propose that these be in three thematic areas: (1) analytical techniques underpinning - omic measurement (2) multi-scale modelling and (3) metabolic engineering. These individuals will contribute to our exemplar projects, initiate their own activity and provide a vital source of expertise for reaching out to new collaborators. The concept of ChELSI is that it will be outward looking. To ensure success it must bridge to the life science community and the UK chemical engineering community. This concept is embedded in every level of what we plan: from the layout of the new facilities, with its ideas space , to our portal concept, our hub-and-spoke model for use of facilities, our multi-level communications plan and the membership of our advisory panel.At the end of the five years funding sought with this bid, we expect ChELSI to be a thriving centre of excellence for chemical engineering at the life science interface. More than 25 individuals will work in Sheffield with the costs of the lecturers and technicians borne by the University. Further there will be active links to other chemical engineering departments in the UK and beyond where chemical engineers have become involved in life-science work, in part we hope, because of ChELSI. The net result of this collection of engineers taking their skills to another problem set will be added vitality in their discipline in the UK, the emergence of the UK as the lead competitor to the USA in this field and emergence of quantitative systems level analysis as a routine tool in UK life science research.Given the rate of progress in life science tools and knowledge, we argue that if investment is not made now, the UK will not bridge the gap to the US, chemical engineering here will diverge in nature from other leading countries and UK biologists will either not have access to these skills or will have to seek them overseas.

在美国以及新加坡和韩国等国家，化学工程师与生物学家在所谓的生命科学界面上广泛合作。在英国，这种合作的数量少得令人担忧。我们建议在切尔西建立一个研究中心，化学工程师将在那里从事生命科学界面的工作。切尔西的目的是建立一个卓越的中心，在自己的权利和接触到整个英国化学工程社区。切尔西将设在谢菲尔德大学化学与过程工程系。切尔西的核心将是来自生物和环境系统集团的现有员工，以及新任命的3名讲师、3名PDRAs、3名博士生、2名技术人员和行政支持人员。谢菲尔德大学将为切尔西提供1000平方米的新实验室、办公室和创意空间。在这次招标中，我们寻求资金支持11名研究人员5年，并提供实验室设备和消耗品，以及小额资金，以促进外部合作。我们对切尔西研究所的愿景是，它将侧重于与人类健康有关的问题。我们在干细胞和再生医学、肾脏疾病、生殖生物学和蛋白质聚集等领域提出初步项目。然而，我们建议的人力资源应该更广泛地面向，并建议在三个主题领域：(1)支持组学测量的分析技术；(2)多尺度建模；(3)代谢工程。这些人将为我们的示范项目做出贡献，发起他们自己的活动，并为接触新的合作者提供重要的专业知识来源。切尔西的理念是向外看。为了确保成功，它必须与生命科学界和英国化学工程界建立联系。这一概念嵌入到我们规划的每一个层面：从新设施的布局及其创意空间，到我们的门户概念，我们的中心辐射式设施使用模式，我们的多层次沟通计划和顾问小组的成员。在五年的资金支持下，我们期望切尔西在生命科学领域成为一个蓬勃发展的化学工程卓越中心。超过25人将在谢菲尔德工作，讲师和技术人员的费用由大学承担。此外，我们还将与英国其他化学工程部门以及其他化学工程师参与生命科学工作的部门建立积极的联系，我们希望这在一定程度上是因为切尔西。这些工程师将他们的技能用于另一个问题集的最终结果将为他们在英国的学科增添活力，英国将成为美国在该领域的主要竞争对手，定量系统水平分析将成为英国生命科学研究的常规工具。鉴于生命科学工具和知识的发展速度，我们认为，如果现在不进行投资，英国将无法弥合与美国的差距，这里的化学工程将在本质上与其他主要国家分道扬镳，英国生物学家要么无法获得这些技能，要么不得不到海外寻求这些技能。

项目成果

Mass spectrometry-based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin.

• DOI: 10.1002/1873-3468.13982
• 发表时间: 2020-12
• 期刊: FEBS letters
• 影响因子: 3.5
• 作者: Al-Majdoub ZM;Achour B;Couto N;Howard M;Elmorsi Y;Scotcher D;Alrubia S;El-Khateeb E;Vasilogianni AM;Alohali N;Neuhoff S;Schmitt L;Rostami-Hodjegan A;Barber J
• 通讯作者: Barber J

Early developing pig embryos mediate their own environment in the maternal tract.

• DOI: 10.1371/journal.pone.0033625
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Almiñana C;Heath PR;Wilkinson S;Sanchez-Osorio J;Cuello C;Parrilla I;Gil MA;Vazquez JL;Vazquez JM;Roca J;Martinez EA;Fazeli A
• 通讯作者: Fazeli A

Identification and characterization of sulfolobus solfataricus P2 proteome using multidimensional liquid phase protein separations.

使用多维液相蛋白质分离鉴定和表征硫磺菌 P2 蛋白质组。

• DOI: 10.1021/pr7006472
• 发表时间: 2008
• 期刊: Journal of proteome research
• 影响因子: 4.4
• 作者: Assiddiq BF