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Platform Grant: Multiscale Mechanobiology for Tissue Engineering

平台资助：组织工程的多尺度力学生物学

基本信息

批准号：
EP/E046975/1
负责人：
David Alan Lee
金额：
$ 126.8万
依托单位：
Queen Mary University of London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FE046975%2F1
关键词：
Platform Grant Multiscale Mechanobiology Tissue

项目摘要

Many tissues in our bodies, such as cartilage, tendon and ligaments are loaded as we move around and the living cells in the tissues are able to detect the loading and alter their activity in response. This process is called mechanotransduction and is important as it keeps the tissues healthy and functioning properly. Damage to cartilage, tendon and ligaments can occurs as a result of injury or through diseases such as arthritis, resulting in pain and loss of function. In many cases the tissues are not able to repair well following damage, causing chronic pain. Until recently the only option for these patients may be a total joint replacement. This is not good solution for younger patients as most joint replacements will only last for 10-15 years before they need to be replaced. Over the past 15 years many groups worldwide have been developing an alternative solution, involving a process know as tissue engineering. Tissue engineering typically involves the creation of a new, functioning tissue in the laboratory, using the patient's own cells and a biomaterial scaffold. The new tissue can be implanted into the patient to repair the damage. As the new tissue will be loaded when implanted back into the patient is very important to understand how loading will affect the activity of the cells. Ideally the cells should respond to the load in a beneficial manner, so that normal exercise and activity improves the repair. In fact it may be beneficial to load the tissue in the laboratory before implantation, using devices known as bioreactors. Mechanotransduction is very complex and not well understood and so more research is needed to understand the process and ultimately to improve tissue engineering-based tissue repair.At Queen Mary University of London we have been studying with the ultimate aim of developing better tissue engineering-based repair systems for cartilage, tendons and ligaments for over 15 years. Our laboratory facilities are very good and we have brought together a team of researchers from many different backgrounds, including engineers, materials scientists, biologists and orthopaedic surgeons. In that time we have developed and we have achieved funding for many individual research projects that have been very successful. The Platform Grant will allow us to develop our research further and underpin our current activity. The funding will ensure that we can retain key members of our research group and perform high-risk pilot studies to improve our chance to gaining funding. We will also be able to improve our collaborative links with the leading groups world-wide who are involved in this type of research.

当我们四处走动时，我们体内的许多组织，如软骨、肌腱和韧带都会受到负荷，组织中的活细胞能够检测到负荷并相应地改变其活动。这个过程称为机械转导，很重要，因为它可以保持组织健康和正常运作。受伤或关节炎等疾病可能会导致软骨、肌腱和韧带受损，导致疼痛和功能丧失。在许多情况下，组织在损伤后无法很好地修复，从而导致慢性疼痛。直到最近，这些患者的唯一选择可能是全关节置换术。对于年轻患者来说，这不是一个好的解决方案，因为大多数关节置换物只能持续 10-15 年，然后就需要更换。在过去的 15 年里，世界各地的许多团体一直在开发一种替代解决方案，其中涉及一种称为组织工程的过程。组织工程通常涉及使用患者自身的细胞和生物材料支架在实验室中创建新的功能组织。新的组织可以植入患者体内以修复损伤。由于新组织在植入回患者体内时会受到负载，因此了解负载将如何影响细胞的活性非常重要。理想情况下，细胞应该以有益的方式对负荷作出反应，以便正常的锻炼和活动可以改善修复。事实上，在植入之前在实验室中使用称为生物反应器的设备加载组织可能是有益的。力转导非常复杂且尚未被很好地理解，因此需要更多的研究来了解该过程并最终改善基于组织工程的组织修复。在伦敦玛丽女王大学，我们15年来一直在研究，其最终目标是开发更好的基于组织工程的软骨、肌腱和韧带修复系统。我们的实验室设施非常好，我们聚集了来自许多不同背景的研究人员团队，包括工程师、材料科学家、生物学家和骨科医生。在那段时间里，我们已经发展并为许多非常成功的个人研究项目获得了资金。平台资助将使我们能够进一步发展我们的研究并支持我们当前的活动。这笔资金将确保我们能够留住研究小组的关键成员并进行高风险的试点研究，以提高我们获得资金的机会。我们还将能够改善与参与此类研究的全球领先团体的合作联系。