Advanced Research Fellowship: Linking the physical and biological sciences to study cell to cell interactions

高级研究奖学金：将物理和生物科学联系起来研究细胞间的相互作用

• 批准号: EP/E053556/1
• 负责人: Catherine Biggs
• 金额: $ 105.2万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE053556%2F1
• 关键词: Advanced; Research; Fellowship; Linking; physical

Cellular interactions are fundamental to all biological processes. Understanding of cell-cell interactions, with the ultimate vision of harnessing this new knowledge for future engineering of bioprocesses, crosses medical, process engineering and environmental disciplines. The observation of cell-cell interactions is not a new phenomenon. However, despite the prevalence and significance of cell-cell interaction in bio-engineering systems, little is understood about how the processes at the molecular level (i.e. the science approach) connect to macro scale characteristics (i.e. the engineering problem. In order to understand, and ultimately engineer and model the process of cell-cell interactions, a combined approach that concurrently addresses the key (and interdependent) (process) engineering, biological and biochemical questions surrounding cell-cell interactions is needed. The development of such an integrated framework is the core philosophy of this fellowship. With my expertise, and the opportunity of this fellowship, I am uniquely placed to bring skills from both the physical/chemical engineering and biological sciences to bear on this bio-engineering issue. A core strength of this fellowship, is my ability to combine biological '-omic' techniques with engineering and colloidal investigations to link biological and physical processes that govern cell to cell interactions Using model bacterial systems (E.coli and B.cereus), I will examine how external drivers (e.g. cell to cell communication) influence cell surface characteristics and ultimately cell to cell interaction. I will extend this study into the archaeal and eukaryotic systems to gain a more holistic view of cell to cell interactions. This fellowhsip is timely, as it will open up new research opportunities to establish international networks with research groups specialising in individual key aspects of cell-cell interactions. This will provide excellent opportunities to apply this integrated approach to new cellular systems. It is also timely because, with the continued development in the biological sciences in relating gene expression to protein function, it is now possible to start relating biological function with specific physical cell characteristics and engineering relevance. The knowledge developed in this fellowship will, as a result, provide the fundamental understanding necessary to unravel the interconnected engineering, biological and physical processes in studying cell to cell interactions, and ultimately lead to innovative ways to manage the processes.

细胞相互作用是所有生物过程的基础。了解细胞间的相互作用，并最终将这些新知识用于未来的生物过程工程，跨越了医学，过程工程和环境学科。观察细胞间的相互作用并不是一个新现象。然而，尽管细胞间相互作用在生物工程系统中的普遍性和重要性，但人们对分子水平上的过程（即科学方法）如何与宏观尺度特征（即工程问题）联系起来知之甚少。为了理解并最终设计和建模细胞-细胞相互作用的过程，需要同时解决围绕细胞-细胞相互作用的关键（和相互依赖的）（过程）工程、生物学和生物化学问题的组合方法。发展这样一个综合框架是本研究金的核心理念。凭借我的专业知识，以及这次奖学金的机会，我处于独特的地位，能够将物理/化学工程和生物科学的技能带到这个生物工程问题上。这个奖学金的一个核心优势，是我的能力，联合收割机生物'-omic'技术与工程和胶体的调查，连接生物和物理过程，管理细胞与细胞的相互作用使用模型细菌系统（大肠杆菌和B.蜡状），我将研究如何外部驱动程序（例如细胞与细胞通信）影响细胞表面特性，并最终细胞与细胞的相互作用。我将把这项研究扩展到古细菌和真核系统，以获得细胞与细胞相互作用的更全面的观点。这项研究是及时的，因为它将开辟新的研究机会，与专门研究细胞间相互作用的各个关键方面的研究小组建立国际网络。这将为将这种集成方法应用于新的蜂窝系统提供极好的机会。这也是及时的，因为随着生物科学在将基因表达与蛋白质功能相关联方面的持续发展，现在可以开始将生物功能与特定的物理细胞特征和工程相关性相关联。因此，在该奖学金中开发的知识将提供必要的基本理解，以解开研究细胞与细胞相互作用的相互关联的工程，生物和物理过程，并最终导致管理过程的创新方法。

项目成果

Harvesting and dewatering yeast by microflotation

• DOI: 10.1016/j.bej.2013.10.019
• 发表时间: 2014-01-15
• 期刊: BIOCHEMICAL ENGINEERING JOURNAL
• 影响因子: 3.9
• 作者: Hanotu, James;Karunakaran, Esther;Zimmerman, William B.
• 通讯作者: Zimmerman, William B.

Influence of fermentation conditions on the surface properties and adhesion of Lactobacillus rhamnosus GG.

• DOI: 10.1186/1475-2859-11-116
• 发表时间: 2012-08-29
• 期刊: Microbial cell factories
• 影响因子: 6.4
• 作者: Deepika G;Karunakaran E;Hurley CR;Biggs CA;Charalampopoulos D
• 通讯作者: Charalampopoulos D

Macromolecular fingerprinting of sulfolobus species in biofilm: a transcriptomic and proteomic approach combined with spectroscopic analysis.

• DOI: 10.1021/pr2003006
• 发表时间: 2011-09-02
• 期刊: JOURNAL OF PROTEOME RESEARCH
• 影响因子: 4.4
• 作者: Koerdt, Andrea;Orell, Alvaro;Trong Khoa Pham;Mukherjee, Joy;Wlodkowski, Alexander;Karunakaran, Esther;Biggs, Catherine A.;Wright, Phillip C.;Albers, Sonja-Verena
• 通讯作者: Albers, Sonja-Verena

The polymer physics and chemistry of microbial cell attachment and adhesion

• DOI: 10.1039/b717046g
• 发表时间: 2008-01-01
• 期刊: FARADAY DISCUSSIONS
• 影响因子: 3.4
• 作者: Geoghegan, Mark;Andrews, Johanna S.;Banwart, Steven A.
• 通讯作者: Banwart, Steven A.

Aggregation and biofilm formation of bacteria isolated from domestic drinking water

• DOI: 10.2166/ws.2013.115
• 发表时间: 2013-01-01
• 期刊: WATER SCIENCE AND TECHNOLOGY-WATER SUPPLY
• 作者: Ramalingam, B.;Sekar, R.;Biggs, C. A.
• 通讯作者: Biggs, C. A.