Console for a 4.7 T small animal MRI system

4.7 T 小动物 MRI 系统控制台

• 批准号: 7391431
• 负责人: STEPHEN B PICKUP
• 金额: $ 49.99万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-18 至 2011-04-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391431
• 关键词: Amplifiers; Animal Model; Animals; Arthritis; Arts; Blood Vessels; Communities; Contrast Media; Data Quality; Development; Disease; Early Diagnosis; Evolution; Funding; Funding Applicant; Hospitals; Human; Image; Imaging Techniques; Injury; Institution; Invasive; Longitudinal Studies; Lysosomal Storage Diseases; Magnetic Resonance Imaging; Malignant neoplasm of pancreas; Metabolism; Myocardial Infarction; Neuraxis; Noise; Non-Hodgkin' s Lymphoma; Numbers; Pediatric Hospitals; Pennsylvania; Phenylacetates; Phenylbutyrates; Philadelphia; Play; Prostaglandin-Endoperoxide Synthase; Radiology Specialty; Research; Research Infrastructure; Resolution; Role; Schizophrenia; Signal Transduction; Slice; Somatic Gene Therapy; System; Techniques; Therapeutic; Time; Tube; United States National Institutes of Health; Universities; Xenograft procedure; cancer cell; cyclooxygenase 1; cyclooxygenase 2; data acquisition; human disease; improved; insight; instrument; instrumentation; melanoma; mouse model; nerve stem cell; novel; phenylacetate; phenylbutyrate; programs; response; stem cell therapy

DESCRIPTION (provided by applicant): Funds are requested to purchase a state of the art console and gradient amplifiers for a small animal magnetic resonance imaging (MRI) scanner. The new instrumentation will be interfaced to an existing horizontal bore 4.7 T, 50 cm magnet equipped with 39 cm ID, 4 gauss/cm and 12 cm ID, 25 gauss/cm gradient tubes. The console will provide several new capabilities including; 1) the ability to perform parallel acquisition techniques resulting in significant reductions in data acquisition time and improved temporal resolution in dynamic contrast studies, 2) acquisition of studies employing multiple slice orientations, 3) improvements in gradient stability and reliability, 4) enhanced signal to noise ratio and 5) an improved user interface. The instrument will become part of the Small Animal Imaging Facility (SAIF) in the Department of Radiology at the University of Pennsylvania. The SAIF provides the infrastructure, administration, instrumentation and expertise necessary to perform small animal imaging to the large, heavily NIH funded research community at University of Pennsylvania, Children's Hospital of Philadelphia, Jefferson Hospital and other nearby institutions. The instrumentation will support numerous NIH funded programs investigating; 1) the therapeutic benefits of stem cell therapy for myocardial infarction, 2) the mechanisms by which phenylacetate and phenylbutyrate inhibit the proliferation of cancer cells, 3) somatic gene transfer to the central nervous system and neural stem cells in animal models of human lysosomal storage diseases, 4) neuroanatomical differences in a mouse model of schizophrenia, 5) acidification of melanoma xenografts 6) response to therapy of non- hodgkins lymphoma, 7) assessment of arthritis, 8) the role of cyclooxygenase metabolism in vascular restructuring following vascular injury and 9) novel contrast agents for early detection of pancreatic cancer in mouse models All of these studies will benefit from the new capabilities afforded by the requested instrumentation. The study of small animal models of human diseases continues to play a central role in the development of new therapies. The utilization of non-invasive radiological imaging techniques, particularly MRI, allows for longitudinal study of the disease thus reducing the number of animals needed and giving insight into the evolution of the disease. The requested instrumentation will expand the capabilities of the existing instrumentation improving both the quality of the data generated and improve the throughput of the instrument.

描述（由申请人提供）：申请资金用于为小动物磁共振成像（MRI）扫描仪购买最先进的控制台和梯度放大器。新仪器将与现有的水平孔4.7 T、50 cm磁体连接，该磁体配备有39 cm ID、4高斯/cm和12 cm ID、25高斯/cm梯度管。控制台将提供几种新功能，包括：1）能够执行并行采集技术，从而显著缩短数据采集时间并提高动态对比研究的时间分辨率，2）采用多个切片方向采集研究，3）提高梯度稳定性和可靠性，4）提高信噪比，以及5）改进用户界面。该仪器将成为宾夕法尼亚大学放射学系小动物成像设施（SAIF）的一部分。SAIF为宾夕法尼亚大学、费城儿童医院、杰斐逊医院和其他附近机构的大型NIH资助的研究社区提供进行小动物成像所需的基础设施、管理、仪器和专业知识。该仪器将支持许多NIH资助的研究项目; 1）干细胞疗法对心肌梗塞的治疗益处，2）苯乙酸和苯丁酸抑制癌细胞增殖的机制，3）在人溶酶体贮积病动物模型中向中枢神经系统和神经干细胞的体细胞基因转移，4）精神分裂症小鼠模型中的神经解剖学差异，5）黑色素瘤异种移植物的酸化6）对非霍奇金斯淋巴瘤治疗的反应，7）关节炎的评估，8）环加氧酶代谢在血管损伤后血管重建中的作用和9）用于小鼠模型中胰腺癌早期检测的新型造影剂所有这些研究都将受益于所要求的仪器提供的新能力。 人类疾病的小动物模型的研究继续在新疗法的开发中发挥核心作用。利用非侵入性放射成像技术，特别是MRI，可以对疾病进行纵向研究，从而减少所需动物的数量，并深入了解疾病的演变。所要求的仪器将扩大现有仪器的能力，提高所产生数据的质量，并提高仪器的吞吐量。