Leachability & Effect of Arsenic, Copper & Chromium Associ. with CCA treated Wood

与暴露于铬酸铜中的砷（As）相关的健康问题 砷酸盐（CCA）处理木材继续引起世界的注意。已经 表明，除了砷，铬（Cr）和铜（Cu）也浸出水平 对水生生物可能有毒。虽然在以下方面取得了相当大的进展： 研究了砷的毒性、三种元素在混合浸出液中的有害作用， 同时，目前未知。缺乏这方面的信息仍然是一个主要问题， 评估CCA处理过的木材对人类健康的潜在影响的障碍。我们的长期 目标是表征并最终降低与以下方面相关的人类健康风险： 暴露于CCA。本研究的主要目的是了解沥滤和 砷、铬和铜对人体的生理影响（细胞行为和代谢） CCA处理的木材为实现这一目标，将开展以下具体工作： 目的：（1）研究砷、铬、铜三种有毒元素的浸出特性 （2）从受影响的土壤和经CCA处理的木材中提取; 使用基于人类神经的模型的As、Cr和Cu单独或混合物的细胞生理学 细胞培养物（细胞系如NSC-34、SH-SY5Y、CATH. a、D384和SK-N-MC）;和3） 确定土壤性质对土壤渗滤液细胞效应的影响。本研究将 本研究基于以下假设：（1）渗滤液的潜在生理效应 与CCA处理的木材对人类的影响是由三个存在 重金属来源于CCA和它们之间的相互作用和低浓度的As，Cr， 和Cu在这些沥滤液中会影响细胞代谢的关键方面;和（2）沥滤 受CCA影响的土壤中这些元素的潜在效应被土壤改变 特性.预计这项研究将提供新的和必要的信息， 评估CCA相关沥滤液对人体的影响。这些结果 将允许改进的预测As，Cr和Cu从CCA处理过的木材中浸出， 通过土壤的迁移，并最终评估可能对人类健康产生的影响 与这些元素的释放有关。因此，我们的成果将使我们能够更多地 准确评估As、Cr和Cu污染对环境和人类健康的影响 由于CCA的应用。

Health problems associated with exposure to arsenic (As) from chromated copper arsenate (CCA)-treated wood continue to command world attention. It has been demonstrated that, in addition to As, chromium (Cr) and copper (Cu) also leach at levels potentially toxic to aquatic organisms. Although considerable progress has been made in studying the toxicity of As, the harmful effects of these three elements in mixtures, leached simultaneously are currently unknown. The lack of this information remains one of the major obstacles to assess the potential effects of CCA-treated wood on human health. Our longterm goal is to characterize and ultimately reduce the human health risks associated with exposure to CCA. The principal objective of this research is to understand the leaching and human physiological effects (cell behavior and metabolism) of As, Cr, and Cu associated with CCA-treated wood. The objective will be accomplished by pursuing the following specific aims: (1) Investigate the leaching characteristics of all three toxic elements, As, Cr, and Cu from CCA-treated wood and from the affected soils; (2) Evaluate the effects on aspects of cell physiology of As, Cr, and Cu alone or in mixtures using a model based on human nerve cell cultures (cell lines such as NSC-34, SH-SY5Y, CATH.a, D384 and SK-N-MC); and 3) Determine the effects of soil properties on the cell effects of soil leachate. This study will be guided by the following hypotheses: (1) The potential physiological effects of the leachates associated with CCA-treated wood to human beings is affected by the presence of the three metals derived from CCA and interactions between them and low concentrations of As, Cr, and Cu in these leachates will affect critical aspects of cell metabolism; and (2) The leaching and potential effects of these elements from soils affected by CCA are altered by soil properties. It is expected that this research will provide new and essential information for assessing the effects of the leachates associated with CCA on human beings. These results will allow improved predictions of leaching of As, Cr, and Cu from CCA-treated wood and their transport through soils and, ultimately, evaluations of possible human health impacts associated with the release of these elements. Our results will, therefore, enable us to more accurately assess the environmental and human health impacts of As, Cr, and Cu pollution resulting from CCA applications.