Leachability & Effect of Arsenic, Copper & Chromium Associ. with CCA treated Wood

与接触镀铬铜中砷(As)有关的健康问题 经过砷酸盐(CCA)处理的木材继续引起世界的关注。一直以来 结果表明，除As外，铬(Cr)和铜(Cu)也在一定程度上浸出 对水生生物有潜在毒性。尽管在以下方面取得了相当大的进展 研究砷的毒性，这三种元素在混合物中的有害影响，淋洗 同时也是目前未知的。缺乏这方面的信息仍然是主要的 评估经CCA处理的木材对人类健康的潜在影响的障碍。我们的长期计划 目标是确定并最终减少与以下因素相关的人类健康风险 暴露在CCA中。这项研究的主要目的是了解淋溶和 与砷、铬和铜相关的人体生理效应(细胞行为和代谢) 经CCA处理的木材。目标将通过追求以下具体目标来实现 目的：(1)研究砷、铬、铜三种有毒元素的淋溶特性 从CCA处理的木材和受影响的土壤中；(2)评估在以下方面的影响 基于人神经的As、Cr、Cu单独或混合模型的细胞生理学研究 细胞培养(NSC-34、SH-SY5Y、CATH.a、D384和SK-N-MC等细胞系)； 确定土壤性质对土壤渗滤液细胞效应的影响。这项研究将是 以以下假设为指导：(1)渗滤液的潜在生理效应 与CCA处理过的木材对人类有关联的是这三种物质的存在 来自CCA的金属及其与低浓度砷、铬、铅、铬、铜、铜、镉、铅、铅、镉、锌、镉、镉、锌等元素之间的相互作用 这些渗滤液中的铜将影响细胞代谢的关键方面；以及(2)淋滤 受CCA影响的土壤中这些元素的潜在影响会因土壤而改变 属性。预计这项研究将为以下方面提供新的重要信息 评估与CCA相关的渗滤液对人类的影响。这些结果 将改善对经CCA处理的木材中砷、铬和铜的浸出的预测 它们在土壤中的迁移，并最终评估可能对人类健康的影响 与这些元素的发布相关联。因此，我们的结果将使我们能够 准确评估砷、铬和铜污染对环境和人类健康的影响 由CCA应用程序产生。

Health problems associated with exposure to arsenic (As) from chromated copper arsenate (CCA)-treated wood continue to command world attention. It has been demonstrated that, in addition to As, chromium (Cr) and copper (Cu) also leach at levels potentially toxic to aquatic organisms. Although considerable progress has been made in studying the toxicity of As, the harmful effects of these three elements in mixtures, leached simultaneously are currently unknown. The lack of this information remains one of the major obstacles to assess the potential effects of CCA-treated wood on human health. Our longterm goal is to characterize and ultimately reduce the human health risks associated with exposure to CCA. The principal objective of this research is to understand the leaching and human physiological effects (cell behavior and metabolism) of As, Cr, and Cu associated with CCA-treated wood. The objective will be accomplished by pursuing the following specific aims: (1) Investigate the leaching characteristics of all three toxic elements, As, Cr, and Cu from CCA-treated wood and from the affected soils; (2) Evaluate the effects on aspects of cell physiology of As, Cr, and Cu alone or in mixtures using a model based on human nerve cell cultures (cell lines such as NSC-34, SH-SY5Y, CATH.a, D384 and SK-N-MC); and 3) Determine the effects of soil properties on the cell effects of soil leachate. This study will be guided by the following hypotheses: (1) The potential physiological effects of the leachates associated with CCA-treated wood to human beings is affected by the presence of the three metals derived from CCA and interactions between them and low concentrations of As, Cr, and Cu in these leachates will affect critical aspects of cell metabolism; and (2) The leaching and potential effects of these elements from soils affected by CCA are altered by soil properties. It is expected that this research will provide new and essential information for assessing the effects of the leachates associated with CCA on human beings. These results will allow improved predictions of leaching of As, Cr, and Cu from CCA-treated wood and their transport through soils and, ultimately, evaluations of possible human health impacts associated with the release of these elements. Our results will, therefore, enable us to more accurately assess the environmental and human health impacts of As, Cr, and Cu pollution resulting from CCA applications.