Chronic Pain and Substance Use in Patients with Hepatitis C

描述(由申请人提供)：这项以患者为导向的研究职业发展奖(K23)的目标是让本杰明·莫拉斯科博士成为一名独立科学家，研究评估和治疗丙型肝炎患者慢性疼痛和共病物质使用障碍(SLID)的创新方法。候选人提出了一项研究和培训计划，目标如下：加深他对疼痛、成瘾和SLID的理解；扩大他关于解决疼痛和SLID的非药物治疗策略的知识；发展丙型肝炎病毒(HCV)患者的心理社会需求方面的专业知识；并获得先进的研究技能，为他成为一名独立调查员做好准备。莫拉斯科博士将在整个奖项过程中与他的导师彼得·毛瑟博士、丹尼斯·特克博士、艾伦·马拉特博士和史蒂文·多布夏博士密切合作，以实现上述目标。俄勒冈健康与科学大学和波特兰退伍军人医学中心的资源，再加上指导团队的专家指导，将为莫拉斯科博士提供理想的机会，发展评估和治疗合并疼痛和滑脱的专业知识。作为K23奖项的一部分，莫拉斯科博士将(1)进行一项横断面研究，研究与丙型肝炎患者慢性疼痛相关的生物、心理和社会因素，(2)开发和试行一种基于群体的认知行为疗法，以减轻丙型肝炎患者的疼痛，改善身体和情绪功能，减少药物使用。这些研究的结果将被用于申请R01资金，以在随机对照试验中测试新开发的干预措施。这项研究的长期目标是更好地了解丙型肝炎患者的治疗需求，并最终改善这一患者群体中疼痛和共病物质使用的治疗。拟议研究的成功完成将使莫拉斯科博士做好准备，成为一名独立的研究员，拥有在疼痛和滑脱的联合治疗方面进行临床研究的专业知识，特别是在丙型肝炎患者的治疗方面。与公共卫生相关：我们预计该项目将提供有关丙型肝炎患者疼痛因素的必要信息。如果新开发的治疗方法有效，丙型肝炎患者与健康相关的生活质量将得到改善。

DESCRIPTION (provided by applicant): The goal of this Mentored Patient-Oriented Research Career Development Award (K23) is for Benjamin Morasco, Ph.D. to become an independent scientist studying innovative approaches for the assessment and treatment of chronic pain and comorbid substance use disorder (SLID) in patients with hepatitis C. The candidate proposes a program of research and training with the following goals: further his understanding of pain, addiction, and SLID; expand his knowledge regarding strategies to address the non-pharmacological treatment of pain and SLID; develop expertise in the psychosocial needs of patients with the hepatitis C virus (HCV); and acquire advanced research skills that will prepare him for a career as an independent investigator. Dr. Morasco will work closely with his mentors, Drs. Peter Mauser, Dennis Turk, Alan Marlatt, and Steven Dobscha throughout the course of this award to meet the above objectives. The resources at the Oregon Health & Science University and Portland VA Medical Center, combined with the expert guidance of the mentoring team, will provide the ideal opportunity for Dr. Morasco to develop expertise in the assessment and treatment of comorbid pain and SLID. As part of this K23 award, Dr. Morasco will (1) conduct a cross-sectional study examining the biopsychosocial factors that are associated with chronic pain in patients with HCV, and (2) develop and pilot test a group-based cognitive-behavioral treatment to reduce pain, improve physical and emotional functioning, and reduce substance use in patients with HCV. Results from these studies will be used to apply for R01 funding to test the newly developed intervention in a randomized controlled trial. The long-term goal of this research is to develop a better understanding of the treatment needs of HCV patients, and ultimately improve the treatment of pain and comorbid substance use in this patient population. Successful completion of the proposed studies will prepare Dr. Morasco to become an independent investigator with expertise conducting clinical research in the combined treatment of pain and SLID, particularly in patients with HCV. Relevance to Public Health: We expect that this project will contribute needed information about the factors that contribute to pain in patients with hepatitis C. If the newly developed treatment is effective, the health-related quality of life among hepatitis C patients will be improved.