Intervention to Prevent Delayed Diagnosis of Oral Cancer

候选人：Alvin G. Wee， BDS， MS， MPH，致力于临床研究的学术生涯。这个K23申请的目的是在临床研究中提供指导，因为他从事职业发展活动，并辅以研究项目。这将使他最终成为一名专注于口腔癌预防和早期检测的独立研究人员。拟议的职业发展活动包括预定与导师和顾问接触，参加有关的研讨会/科学会议、学术课程和夏季方案。环境：俄亥俄州立大学（OSU）健康科学校园提供了丰富的环境，有广泛的研究活动，建立导师和必要的物质资源来支持这一应用程序的活动。与此申请相关的校园组成部分包括牙科学院、综合癌症中心（CCC）、公共卫生学院、耳鼻喉科、心理学和内科。所有的导师和顾问都在现场，在他们的领域有充足的资金，并有指导临床研究人员的经验。主要指导将由E. D. Paskett提供，他是公共卫生学院癌症研究的Marion N. Rowley教授和俄勒冈州立大学人口科学中心副主任。提供指导的其他共同导师和顾问具有与研究项目相关的专业知识。研究：这项提议的一般假设是，有患口腔癌风险的人群更有可能去看其他医疗保健专业人员，而不是牙医。该研究项目的目的是开发和测试基于网络的初级保健医生教育干预的可行性，以促进口腔癌的早期发现（目标#3）。获得的与患者相关的决定因素（目标1）和与口腔癌晚期诊断相关的医疗保健相关的决定因素（目标2）的信息都将有助于基于网络的教育干预的发展。相关性：该应用与2010年健康人的两个目标相关：(1)将早期发现的口腔癌和咽癌的比例从基线的35%提高到目标的50%，(2)将报告在过去12个月内接受过口腔和咽癌检查的成年人比例从基线的13%提高到目标的20%。

DESCRIPTION (provided by applicant): Candidate: Alvin G. Wee, BDS, MS, MPH has shown strong commitment to an academic career in clinical research. The goal of this K23 application is to provide mentored guidance in clinical research as he engages in career development activities complemented by a research program. This will finalize his transition toward becoming an independent researcher focusing on the prevention and early detection of oral cancer. Proposed career development activities include scheduled contacts with mentors and consultants and attending relevant seminars/scientific meetings, academic courses and summer programs. Environment: Ohio State University (OSU) Health Science Campus provides a rich environment with extensive research activities, established mentors and physical resources necessary to support the activities of this application. Relevant components of the Campus to this application includes the College of Dentistry, Comprehensive Cancer Center (CCC), School of Public Health, and Departments of Otolaryngology, Psychology and Internal Medicine. All mentors and consultants are onsite, are well funded in their fields, and have experience in mentoring clinical researchers. Primary mentorship will be provided by E. D. Paskett, the Marion N. Rowley Professor of Cancer Research at the School of Public Health and Associate Director of Population Sciences, OSU CCC. Other co-mentors and consultants that will provide guidance have relevant expertise to the research program. RESEARCH: The general hypothesis of this proposal is that groups at risk for developing oral cancer are more likely to see other healthcare professionals for their medical problems than dentists. The objective of the research program is to develop and test the feasibility of a web-based educational intervention for primary care physicians to promote early detection of oral cancer (Aim #3). Information obtained on patient-related determinants (Aim #1) and healthcare-related determinants relevant to late stage diagnosis of oral cancer (Aim #2) will both contribute to the development of the web-based educational intervention. RELEVANCE: This application is relevant to two objectives of the Healthy People 2010: (1) to increase the portion of oral and pharyngeal cancer that is detected at the earliest stage, from baseline of 35% to target of 50%, and (2) to increase the portion of adults who report having had an examination to detect oral and pharyngeal cancer in the past 12 months from the 13% baseline to the target of 20%.