Study of Valproic Acid in Pediatric Brain Tumors

丙戊酸治疗小儿脑肿瘤的研究

• 批准号: 7485729
• 负责人: JACK Meng Fen SU
• 金额: $ 13.5万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7485729
• 关键词: Acetylation; Adult; Animal Model; Apoptosis; Biology; Blood - brain barrier anatomy; Brain; Cancer cell line; Cell Line; Cell Nucleus; Cells; Central Nervous System Neoplasms; Child; Childhood; Childhood Brain Neoplasm; Childhood Central Nervous System Neoplasm; Children' s Oncology Group; Chronic; Class; Clinical; Clinical Trials; Cognitive; Commit; Data; Development; Disease Progression; Dose; Dose-Limiting; Drug Kinetics; Enrollment; Glioblastoma; Goals; Growth; Histone Acetylation; Histone Deacetylase; Histone Deacetylase Inhibitor; Histone H3; Histone deacetylase inhibition; Histones; Human; In Vitro; Literature; Maintenance Therapy; Malignant Glioma; Malignant neoplasm of brain; Maximum Tolerated Dose; Measures; Modality; Molecular; Neuraxis; Newly Diagnosed; Outcome; Patients; Personal Satisfaction; Pharmaceutical Preparations; Phase; Phase I Clinical Trials; Phase II Clinical Trials; Phase III Clinical Trials; Phenylbutyrates; Poly(ADP-ribose) Polymerases; Progression-Free Survivals; Protein Binding; Radiation; Radiation Tolerance; Radiation Toxicity; Radiation therapy; Randomized; Recurrence; Recurrent tumor; Refractory; Research Personnel; Residual Tumors; Safety; Serum; Shunt Device; Solid; Solid Neoplasm; Spinal Puncture; Spinal Tap; Surrogate Markers; Time; Toxic effect; Translating; Valproic Acid; Week; Xenograft Model; base; career; chemotherapy; cohort; design; experience; improved; in vivo; inhibitor/antagonist; medulloblastoma; molecular oncology; monocyte; neuro-oncology; neurosurgery; novel; outcome forecast; peripheral blood; phenylbutyrate; preclinical study; programs; response; temozolomide; tumor

DESCRIPTION (provided by applicant): Dr. Su's long-term career objectives are to identify novel treatments and develop biology-driven, mechanism-specific clinical trials in pediatric neuro-oncology. His current focus is on studying valproic acid and other related histone deacetylase (HDAC) inhibitors as novel treatments for medulloblastomas (MB). Based on his pre-clinical studies, Dr. Su is currently conducting a Phase 1 clinical trial of valproic acid in children with recurrent solid and CNS tumors through the Children's Oncology Group. The major goals of this Phase 1 clinical trial are to document the toxicities and pharmacokinetics of chronic valproic acid administration in children with recurrent tumors and determine the correlation between serum drug concentrations and histone hyper-acetylation, the proposed anti-tumor mechanism. Dr. Su has completed a proposal for a subsequent Phase 2 clinical trial to study valproic acid's efficacy against recurrent pediatric CNS tumors, and this proposal will be submitted to a national cooperative group upon completion of the ongoing Phase 1 clinical trial. Dr. Su and his collaborators have also demonstrated valproic acid's potential in protecting normal brain against radiation-damage, enhancing MBs' radiation sensitivity, and treating minimal residual tumors. Accordingly, Dr. Su plans to initiate a Phase 1 clinical trial to study the safety of administering valproic acid concomitantly with radiation in children newly diagnosed with MBs. If his initial clinical trials showed that valproic acid has promising activities against MBs, Dr. Su will explore the potential for a national cooperative group Phase 3 trial, in which patients receive valproic acid with up-front radiation, complete chemotherapy, and then are randomized to observation versus valproic acid for a year. Dr. Su and his collaborators also plan to evaluate additional HDAC inhibitors, as they may be more potent and less toxic than valproic acid. Another pre-clinical study is planned to evaluate the combined efficacies of temozolomide and a poly (ADP- ribose) polymerase (PARP) inhibitor against pediatric malignant gliomas and MBs. In summary, Dr. Su's has demonstrated early promise in translating molecular discoveries into clinical trials, and he is committed to his career development as an independent clinical researcher in pediatric neuro-oncology.

描述（由申请人提供）：苏博士的长期职业目标是确定新的治疗方法，并在儿科神经肿瘤学中开发生物学驱动的，机制特异性的临床试验。他目前的重点是研究丙戊酸和其他相关的组蛋白去乙酰化酶（HDAC）抑制剂作为髓母细胞瘤（MB）的新治疗方法。基于他的临床前研究，苏博士目前正在通过儿童肿瘤组进行丙戊酸在复发性实体瘤和CNS肿瘤儿童中的I期临床试验。这项I期临床试验的主要目的是记录复发性肿瘤儿童长期给予丙戊酸的毒性和药代动力学，并确定血清药物浓度与组蛋白超乙酰化（拟定的抗肿瘤机制）之间的相关性。苏博士已完成了后续2期临床试验的提案，研究丙戊酸对儿童复发性CNS肿瘤的疗效，该提案将在正在进行的1期临床试验完成后提交给国家合作组。苏博士和他的合作者还证明了丙戊酸在保护正常大脑免受辐射损伤，增强MB的辐射敏感性和治疗微小残留肿瘤方面的潜力。因此，Su博士计划启动一项I期临床试验，以研究在新诊断为MB的儿童中给予丙戊酸伴随放疗的安全性。如果他的初步临床试验表明丙戊酸对MB具有有希望的活性，Su博士将探索国家合作组3期试验的可能性，在该试验中，患者接受丙戊酸与前期放疗，完全化疗，然后随机观察丙戊酸一年。苏博士和他的合作者还计划评估其他HDAC抑制剂，因为它们可能比丙戊酸更有效，毒性更低。另一项临床前研究计划评估替莫唑胺和聚（ADP-核糖）聚合酶（PARP）抑制剂对儿童恶性胶质瘤和MB的联合疗效。总之，苏博士在将分子发现转化为临床试验方面表现出了早期的承诺，他致力于作为儿科神经肿瘤学独立临床研究人员的职业发展。