In-Vivo Study of an Oxirane Low Shrink-Stress Composite

描述（由申请人提供）：John H. Purk是一名执业普通牙医。自1983年以来，他一直在UMKC牙科学院全职教授牙科手术。2002年，他完成了口腔生物学/工程学的非学科博士学位。他的论文是一项体内临床研究。他的近期目标是发展成为一名独立的临床研究人员，可以设计，组织，表征牙本质粘合界面，并进行临床研究。他的长期目标是培训年轻的研究人员如何进行临床研究和进行转化研究。该申请分为两个领域;研究职业发展计划（教学）和临床研究项目。 第一个教学部分将提供课程，包括临床试验的设计、实施、分析和评估方面的临床研究培训，强调流行病学、生物统计学和数据分析的重要性。在显微拉曼光谱，以表征在粘接剂-牙本质（a/d）界面的粘合剂树脂的渗透额外的课程将进行。第二个教学经验部分旨在帮助主要研究者观察教学信息如何整合到研究中心正在进行的临床研究项目中，并帮助主要研究者建立一个体外实验室，该实验室可以模拟牙髓正压以模拟体内条件。这些课程和经验将使候选人在设计和进行模拟体内和临床研究方面发展独立性和专业知识。 研究部分结合1.初步体外试验研究和2.一种新出现的低收缩/低应力的双环氧乙烷粘合剂系统用于修复儿童和成人恒牙邻间龋齿的体内试验性评价。还将对这些体内修复进行体外力学和形态学分析。候选人将为新型牙科粘合剂复合材料系统开发一个独特的数据库，其中包括临床特征，例如术后敏感性、微拉伸粘结强度、树脂渗透和（辅助）界面处空隙形成的定量信息。对这些数据的分析将提供关于（a/d）界面内变化的关键新数据，这将有助于研究人员评估生物材料科学，以及新兴的低收缩/低应力环氧乙烷粘合剂技术的聚合和应力特性。本项目的总体假设是，放置在恒前磨牙中的II类复合材料修复体的临床性能取决于龈缘处令人满意的粘结的发展，并且新型低收缩/低应力牙本质粘合剂和树脂复合材料将导致II类树脂复合材料修复体的龈缘处的上级粘结。具体目标将测试以下假设：与传统的Bis-GMA树脂复合材料系统相比，新型低收缩/低应力粘合剂双环氧乙烷树脂粘合剂系统将具有更大的微拉伸粘合强度和粘合剂渗透到II类复合材料牙龈壁，并且在（a/d）界面处形成更少的空隙。

DESCRIPTION (provided by applicant): John H. Purk is a practicing general dentist. Since 1983 he has taught Operative Dentistry full time at UMKC School of Dentistry. In 2002, he completed an Indisciplinary PhD in Oral Biology/Engineering. His dissertation was an in-vivo clinical research study. His immediate goal is to develop into an independent clinical researcher who can design, organize, characterize the dentin adhesive interface, and conduct clinical research. His long term goal is to train young investigators how to conduct clinical research and conduct translational research. This application is divided into two areas; research career development plan (didactic) and clinical research project. The first didactic component will provide coursework that includes clinical research training in the designing, implementing, analysis and assessment of clinical trials stressing the importance of epidemiology, biostatistics and analysis of data. Additional coursework in micro-Raman spectroscopy in order to characterize the infiltration of the adhesive resin at the adhesive-dentin (a/d) interface will be undertaken. The second didactic experiential component is intended to help the principal investigator observe how didactic information is integrated into an ongoing clinical research project at a study center and also for the principal investigator to set up an in-vitro lab which can simulate positive pulpal pressure to simulate in-vivo conditions. These courses and experiences will allow the candidate to develop independence and expertise in designing and conducting simulated in-vivo and clinical research. The research part combines 1. a preliminary in-vitro pilot study and 2. an in-vivo pilot evaluation of a new emerging low shrink/low stress siloxirane adhesive system for the restoration of interproximal caries in the permanent teeth of children and adults. An in-vitro mechanical and morphologic analyses of these in-vivo restorations following their extraction will also occur. The candidate will develop a unique database for the new dental adhesive composite system that includes clinical features e.g. post-op sensitivity, microtensile bond strength, quantitative information on resin infiltration and void formation at the (aid) interface. The analysis of this data will provide critical, new data on changes within the (a/d) interface which will help researchers evaluate the biomaterials science, and the polymerization and stress properties of a new emerging low shrink/low stress siloxirane adhesive technology. The overall hypotheses of this project are that the clinical performance of class II composite restorations placed in permanent premolars depends on the development of a satisfactory bond at the gingival margin and that a new low shrink/low stress dentin adhesive and resin composite will result in a superior bond at the gingival margin of the class II resin composite restoration. The specific aims will test the following hypotheses: A new low shrink/low stress adhesive siloxirane resin adhesive system compared to a traditional Bis-GMA resin composite system will have a greater microtensile bond strength and adhesive penetration to the gingival wall of class II composite restorations and less void formation at the (a/d) interface.