Chlorhexidine and Pneumonia in Nursing Home Residents

疗养院居民的洗必太和肺炎

• 批准号: 7364599
• 负责人: CATHERINE J BINKLEY
• 金额: $ 12.83万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7364599
• 关键词: Accounting; Address; Affect; Analysis of Variance; Aspirate substance; Award; Bacteria; Case Fatality Rates; Chlorhexidine; Clinical; Clinical Research; Clinical Trials; Communities; Condition; Conduct Clinical Trials; Consultations; Control Groups; Controlled Clinical Trials; Daily; Data; Databases; Dentistry; Dentures; Development; Development Plans; Diagnosis; Drug resistance; Economics; Effectiveness; Elderly; Epidemiology; Ethical Issues; Event; Faculty; Future; General Practices; Geriatrics; Gingival Indexes; Goals; Health; Health Care Costs; Incidence; Individual; Infection; Instruction; Intensive Care Units; Intervention; Investigator-Initiated Research; Knowledge; Lead; Length of Stay; Life; Longevity; Lung; Manuals; Measures; Medical Records; Medical Surveillance; Mentors; Mentorship; Methods; Morbidity - disease rate; Mouthwash; Mucous Membrane; Multi-Drug Resistance; Multi-Institutional Clinical Trial; Numbers; Nursing Homes; Oral; Oral Examination; Oral cavity; Oral health; Oropharyngeal; Outcome; Palate; Patients; Physicians; Placebo Control; Placebos; Pneumonia; Population; Preventive; Prophylactic treatment; Randomized; Rate; Reporting; Research; Research Institute; Research Personnel; Research Project Grants; Research Proposals; Research Training; Residencies; Resources; Role; Saline; Sampling; Scientist; Site; Solid; Solutions; Supervision; Surface; Swab; Systemic disease; Testing; Time; Tongue; Tooth structure; Toothbrushing; Training; United States; United States National Institutes of Health; antimicrobial; base; career; cost; day; design; disorder control; dissemination research; effectiveness clinical trial; experience; hazard; health disparity; human disease; improved; knowledge base; mortality; older patient; oral care; pathogen; patient oriented; prevent; programs; respiratory; tongue dorsum; toothbrush; trend

The immediate goal of this four-year research career award is to further the candidate's development as a patient-oriented researcher, with a focus on oral health and systemic disease. The career development plan will build on her clinical experience as a General Practice Residency Program director and on her research training in Epidemiology. The long-term goal of the career development plan is to enable the candidate to become an independent investigator in oral and systemic health research and to serve as a mentor for junior patient-oriented researchers. The specific training targets are as follows: 1) Attainment of a solid knowledge base in the design and conduct of clinical trials; 2) coursework and consultation in clinical trial and data analytic methods; 3) understanding of procedural, philosophical, and ethical issues arising in the design and conduct of clinical trials; 4) development, based on results and questions raised by the proposed study, of a multi-site clinical effectiveness trial to improve the oral and systemic health of dependent nursing home patients, and 6) dissemination of research findings to investigators in dentistry and other biomedical fields. Under the mentorship of Dr. Dan Sessler, a senior investigator in clinical trials and Director of the Outcomes Research Institute, Dr. Denis Kinane, a senior research scientist and Director of the Center for Oral Health and Systemic Disease, and Dr. Christine Ritchie, a Geriatric Medicine physician at the Center for Oral Health and Systemic Disease, the candidate will pursue a focused clinical research project and will receive formal and practical instruction in all aspects of clinical investigation. The proposed clinical research is needed to add to the knowledge concerning the role of oral health and systemic disease in a population with health disparities. The candidate's firsthand research training will involve the implementation of a pilot randomized, placebo controlled clinical trial of the effects of chlorhexidine oral spray in reducing pneumonia in dependent nursing home patients. The results of the proposed research will serve as the basis for the design and submission of an investigator-initiated research proposal before the end of the award.

这个为期四年的研究职业奖的直接目标是进一步发展候选人作为一个以病人为导向的研究人员，重点是口腔健康和全身性疾病。职业发展计划将建立在她的临床经验，作为一个全科医生住院医师计划主任和她在流行病学的研究培训。职业发展计划的长期目标是使候选人成为口腔和全身健康研究的独立研究者，并担任初级患者导向研究人员的导师。具体培训目标如下：1）获得临床试验设计和实施的坚实知识基础; 2）临床试验和数据分析方法的课程和咨询; 3）理解临床试验设计和实施中出现的程序，哲学和伦理问题; 4）根据拟议研究的结果和提出的问题，开展多中心临床有效性试验，以改善依赖护理之家患者的口腔和全身健康，以及6）向牙科和其他生物医学领域的研究人员传播研究成果。在临床试验高级研究员兼结果研究所所长Dan Sessler博士、口腔健康和全身性疾病中心高级研究科学家兼主任Denis Kinane博士和口腔健康和全身性疾病中心老年医学医师克莉丝汀里奇博士的指导下，候选人将从事重点临床研究项目，并将接受临床研究各个方面的正式和实际指导。建议的临床研究需要增加有关口腔健康和全身性疾病在健康差异人群中的作用的知识。候选人的第一手研究培训将涉及实施一项试验性随机、安慰剂对照临床试验，研究氯己定口服喷雾剂在减少依赖性疗养院患者肺炎方面的作用。拟议研究的结果将作为设计的基础，并在颁奖结束前提交一份由赞助商发起的研究提案。