Prevalence and Risk Factors for Anal Human Papillomavirus in Heterosexual Men: Th

异性恋男性中肛门人乳头瘤病毒的患病率和危险因素：Th

• 批准号: 7599220
• 负责人: ALAN GASPAR NYITRAY
• 金额: $ 11.68万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7599220
• 关键词: Age; Anal canal; Anogenital Human Papilloma Virus Infection; Anogenital cancer; Anus; Archives; Arizona; Behavioral; Biological; Brazil; Cancer Burden; Cancer Center; Characteristics; Coitus; Collaborations; Communities; Confidence Intervals; Country; Cross-Sectional Studies; Data; Data Analyses; Epidemiology; Female; Florida; Frequencies; Genotype; Goals; Heterosexuals; Human Papillomavirus; Human papillomavirus 6; Incidence; Infection; International; Laboratories; Learning; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Mexico; Multivariate Analysis; Oncogenic; Polymerase Chain Reaction; Population; Prevalence; Prevention approach; Recording of previous events; Recruitment Activity; Reporting; Research; Research Design; Research Institute; Research Personnel; Risk Factors; Sampling; Sex Behavior; Sexual Partners; Sexually Transmitted Diseases; Specimen; Testing; Time; United States; Vaccination; Woman; base; experience; male; man; men; prospective; sex

DESCRIPTION (provided by applicant): Human papillomavirus (HPV) is a sexually transmitted infection and primary cause of anal cancer. While male anal cancer incidence in the US has increased almost threefold in three decades, anal HPV prevalence and risk factors in men, especially heterosexual men, remain largely unknown. We have recently estimated an anal canal HPV prevalence of 16.6% in 222 men who denied any lifetime sex with another man. In our analysis of these data, we also found significant univariate associations between anal HPV and decreased age, increased lifetime number of female sexual partners, and frequency of sexual intercourse in the previous month. In multivariate analysis, number of lifetime sexual partners and frequency of sex was independently associated with anal HPV. Our long term goal is to increase our understanding of anal HPV in heterosexual men so that prevention approaches such as vaccination can be developed and implemented to reduce anal cancer burden. The focus of this application is to determine the prevalence and risk factors for anal HPV in heterosexual men. Our hypothesis is that anal HPV in heterosexual men is a common infection inversely associated with age. This hypothesis can be efficiently tested given the availability of anal canal specimens from a large multinational study conducted by our collaborators at the H. Lee Moffitt Cancer Center. Dr. Anna Giuliano and colleagues have collected and archived anal canal samples from 1200 men recruited in Tampa, Florida; Morelos state, Mexico; and Sao Paulo, Brazil. We propose to test these anal canal samples for HPV. The specific aims of this cross-sectional study are designed to exploit the availability of the anal canal specimens from the larger study of 1200 men: Specific Aim 1. Using archived anal canal samples, determine the type-specific anal HPV prevalence in 1200 men; and Specific Aim 2. Identify factors independently associated with anal HPV in the 1200 men. HPV is a common sexually transmitted infection responsible for a variety of anogenital cancers including anal cancers in men. However, a high anal HPV prevalence in heterosexual men, if confirmed, will challenge assumptions about the epidemiology of HPV in men. The dramatically increased incidence of anal cancers in men in the last three decades underscores the need to learn more about prevalence of anal HPV in men (Specific Aim 1) and the risk factors most commonly associated with anal HPV in these men (Specific Aim 2). The focus of this application is to determine the prevalence and risk factors for anal HPV in 1200 heterosexual men. Our hypothesis is that anal HPV in heterosexual men is a common infection inversely associated with age.

描述（由申请人提供）： 人乳头状瘤病毒（HPV）是一种性传播感染和肛门癌的主要原因。虽然美国男性肛门癌的发病率在三十年内增加了近三倍，但男性，特别是异性恋男性的肛门HPV患病率和风险因素在很大程度上仍然未知。我们最近估计，在222名否认与另一名男子发生过任何终身性行为的男性中，肛管HPV的患病率为16.6%。在对这些数据的分析中，我们还发现肛门HPV与年龄下降、女性性伴侣数量增加以及上个月性交频率之间存在显著的单变量关联。在多变量分析中，终生性伴侣数量和性生活频率与肛门HPV独立相关。我们的长期目标是增加我们对异性恋男性肛门HPV的了解，以便开发和实施预防方法，如疫苗接种，以减少肛门癌负担。本申请的重点是确定异性恋男性肛门HPV的患病率和危险因素。我们的假设是，异性恋男性的肛门HPV是一种常见的感染，与年龄呈负相关。鉴于我们的合作者在H。李莫菲特癌症中心。安娜朱利亚诺博士和同事们从佛罗里达的坦帕、墨西哥的莫雷洛斯州和巴西的圣保罗招募了1200名男性，收集并存档了他们的肛管样本。我们建议对这些肛管样本进行HPV检测。这项横断面研究的具体目的是利用来自1200名男性的大型研究的肛管标本的可用性：具体目的1。使用存档的肛管样本，确定1200名男性的肛门HPV感染率;和具体目标2。在1200名男性中确定与肛门HPV独立相关的因素。HPV是一种常见的性传播感染，导致各种肛门生殖器癌症，包括男性肛门癌。然而，如果得到证实，异性恋男性肛门HPV的高患病率将挑战男性HPV流行病学的假设。在过去的三十年里，男性肛门癌的发病率急剧增加，这强调了需要更多地了解男性肛门HPV的患病率（具体目标1）以及这些男性肛门HPV最常见的相关风险因素（具体目标2）。本申请的重点是确定1200名异性恋男性肛门HPV的患病率和危险因素。我们的假设是，异性恋男性的肛门HPV是一种常见的感染，与年龄呈负相关。