THE AGES STUDY - THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENUM

NIDCD项目描述：ags &#8722；Reykjavik研究正在研究遗传易感性和基因/环境相互作用，因为这些因素会导致老年人常见的表型，包括听力损失。NIDCD为本研究提供的听力成分和平衡问卷将支持听力学检查，包括耳镜检查、声阻抗（双侧鼓室测量和同侧声反射）和纯音、空气传导听力学，以确定每只耳朵在500、1000、2000、3000、4000、6000和8000hz时的听力阈值。通过与国家老龄研究所（NIA）之前的机构内协议，2001年至2006年，NIDCD在冰岛雷克雅未克资助了约5200名年龄在67至93岁之间的受试者的听力测试，年龄，基因/环境易感性研究（ages# 8722;Reykjavik I）。D6在目前的AGES - Reykjavik II， NIA和共同发起的ic （NIDCD， NEI和NINDS）正在资助纵向随访检查。在NIDCD的资助下，将询问有关助听器的使用、听力灵敏度的主观评估（包括加劳德特量表）、耳鸣（频率和持续时间）、耳部疾病和手术以及与听力相关的其他因素的问题。还将询问研究参与者经历过（自age I以来）或目前正在经历的特定头晕/平衡和跌倒问题。为了检查广泛的遗传影响，将在现有的AGES数据中确定一级亲属（即兄弟姐妹和亲子组合）。二级亲属或更远的表兄妹也会被识别出来。听力损失遗传学的进一步研究将通过参与广泛的基因组扫描来完成，以确定与特定表型的关联，包括基于AGES I结果定义的与年龄相关的听力损失。

NIDCD Project Description: The AGES−Reykjavik Study is examining genetic susceptibility and gene/environment interaction as these contribute to phenotypes common in old age, including hearing loss. The NIDCD funding of the hearing component and balance questionnaires for this study will support audiometric examinations consisting of otoscopy, acoustic immittance (bilateral tympanometry and ipsilateral acoustic reflexes), and pure-tone, air-conduction audiometry to determine hearing thresholds in each ear at 500, 1000, 2000, 3000, 4000, 6000, and 8000 Hz. Through a prior IntraAgency Agreement with the National Institute on Aging (NIA), NIDCD funded hearing exams on about 5,200 subjects, aged 67 to 93 years in the Age, Gene/Environment Susceptibility Study−Reykjavik (AGES−Reykjavik I) in Reykjavik, Iceland from 2001 through 2006. D6 In the present AGES¿Reykjavik II, NIA and co-sponsoring ICs (NIDCD, NEI, and NINDS) are funding longitudinal follow-up exams. With NIDCD funding, questions will be asked about use of hearing aids, subjective evaluation of hearing acuity including the Gallaudet scale, tinnitus (frequency and duration), ear diseases and operations, and other factors related to hearing. Questions will also be asked about specific dizziness/balance and falling problems that study participants have experienced (since AGES I) or are experiencing currently. In order to examine broad genetic effects, first-degree relatives will be identified in the existing AGES data (i.e., siblings and parent-child combinations). Second-degree relatives or more distant cousins will also be identified. Further investigation of the genetics of hearing loss will be accomplished through participation in a broad genome scan for associations with defined phenotypes, including age-related hearing loss defined on the basis of results in AGES I.