THE AGES STUDY - THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENUM

NIDCD项目描述：雷克雅未克的AGES研究正在研究遗传易感性和基因/环境相互作用，因为这些因素导致了老年人常见的表型，包括听力损失。NIDCD对听力部分的资助和这项研究的平衡问卷将支持听力检查，包括耳镜检查、声导抗(双侧鼓室导纳测量和同侧声反射)，以及纯音、空气传导测听，以确定每只耳朵在500、1000、2000、3000、4000、6000和8000赫兹的听力阈值。通过与国家老龄研究所(NIA)事先达成的机构内协议，NIDCD资助了2001年至2006年在冰岛雷克雅未克对年龄、基因/环境敏感性研究(AGEs&8722；Reykjavik I；Agees&8722；Reykjavik I)约5 200名受试者进行的听力检查。D6在当今时代，雷克雅未克II、NIA和共同赞助的IC(NIDCD、NEI和NINDS)正在资助纵向后续检查。在NIDCD的资助下，将询问有关助听器的使用、对听力的主观评估(包括Gallaudet分级)、耳鸣(频率和持续时间)、耳朵疾病和手术以及其他与听力有关的因素。还将询问研究参与者(从我年龄开始)或目前正在经历的具体头晕/平衡和跌倒问题。为了检查广泛的遗传效应，将在现有的年龄数据中确定一级亲属(即兄弟姐妹和亲子组合)。二级亲属或更远的堂兄弟姐妹也将被识别出来。对听力损失遗传学的进一步研究将通过参与广泛的基因组扫描来完成，以寻找与定义的表型相关的联系，包括根据年龄I的结果定义的年龄相关性听力损失。

NIDCD Project Description: The AGES−Reykjavik Study is examining genetic susceptibility and gene/environment interaction as these contribute to phenotypes common in old age, including hearing loss. The NIDCD funding of the hearing component and balance questionnaires for this study will support audiometric examinations consisting of otoscopy, acoustic immittance (bilateral tympanometry and ipsilateral acoustic reflexes), and pure-tone, air-conduction audiometry to determine hearing thresholds in each ear at 500, 1000, 2000, 3000, 4000, 6000, and 8000 Hz. Through a prior IntraAgency Agreement with the National Institute on Aging (NIA), NIDCD funded hearing exams on about 5,200 subjects, aged 67 to 93 years in the Age, Gene/Environment Susceptibility Study−Reykjavik (AGES−Reykjavik I) in Reykjavik, Iceland from 2001 through 2006. D6 In the present AGES¿Reykjavik II, NIA and co-sponsoring ICs (NIDCD, NEI, and NINDS) are funding longitudinal follow-up exams. With NIDCD funding, questions will be asked about use of hearing aids, subjective evaluation of hearing acuity including the Gallaudet scale, tinnitus (frequency and duration), ear diseases and operations, and other factors related to hearing. Questions will also be asked about specific dizziness/balance and falling problems that study participants have experienced (since AGES I) or are experiencing currently. In order to examine broad genetic effects, first-degree relatives will be identified in the existing AGES data (i.e., siblings and parent-child combinations). Second-degree relatives or more distant cousins will also be identified. Further investigation of the genetics of hearing loss will be accomplished through participation in a broad genome scan for associations with defined phenotypes, including age-related hearing loss defined on the basis of results in AGES I.